hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_05263
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CCNE1 | G1/S-specific cyclin-E1 | UniProt NCBI |
| CDK2 | Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase) | UniProt NCBI |
| CCNE2 | G1/S-specific cyclin-E2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-69200 | 1.79838764402e-09 | 1.0 | CCNE2 CCNE1 CDK2 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes |
| GO:0097134 | 9.08185760231e-08 | 1.0 | CCNE2 CCNE1 CDK2 | cyclin E1-CDK2 complex |
| REAC:R-HSA-6804116 | 1.63653275606e-07 | 1.0 | CCNE2 CCNE1 CDK2 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest |
| KEGG:04115 | 1.25293548061e-06 | 1.0 | CCNE2 CCNE1 CDK2 | p53 signaling pathway |
| REAC:R-HSA-1538133 | 1.31507096469e-06 | 1.0 | CCNE2 CCNE1 CDK2 | G0 and Early G1 |
| WP:WP45 | 2.55779891663e-06 | 1.0 | CCNE2 CCNE1 CDK2 | G1 to S cell cycle control |
| WP:WP707 | 3.08557722297e-06 | 1.0 | CCNE2 CCNE1 CDK2 | DNA Damage Response |
| CORUM:5560 | 3.35600554376e-06 | 0.666666666667 | CCNE1 CDK2 | CDK2-CCNE1 complex |
| WP:WP1530 | 3.5258218805e-06 | 1.0 | CCNE2 CCNE1 CDK2 | miRNA Regulation of DNA Damage Response |
| KEGG:05215 | 3.53290275205e-06 | 1.0 | CCNE2 CCNE1 CDK2 | Prostate cancer |
| KEGG:05222 | 3.776488999e-06 | 1.0 | CCNE2 CCNE1 CDK2 | Small cell lung cancer |
| KEGG:04114 | 5.96891558343e-06 | 1.0 | CCNE2 CCNE1 CDK2 | Oocyte meiosis |
| WP:WP2446 | 6.82717373445e-06 | 1.0 | CCNE2 CCNE1 CDK2 | Retinoblastoma Gene in Cancer |
| REAC:R-HSA-6791312 | 7.77622817275e-06 | 1.0 | CCNE2 CCNE1 CDK2 | TP53 Regulates Transcription of Cell Cycle Genes |
| KEGG:04110 | 8.44552612263e-06 | 1.0 | CCNE2 CCNE1 CDK2 | Cell cycle |
| WP:WP4658 | 8.9153568796e-06 | 1.0 | CCNE2 CCNE1 CDK2 | Small cell lung cancer |
| CORUM:1656 | 1.00675659188e-05 | 0.666666666667 | CCNE1 CDK2 | p27-cyclinE-CDK2 complex |
| KEGG:05162 | 1.02659874862e-05 | 1.0 | CCNE2 CCNE1 CDK2 | Measles |
| KEGG:05226 | 1.10108501715e-05 | 1.0 | CCNE2 CCNE1 CDK2 | Gastric cancer |
| KEGG:04934 | 1.37523983447e-05 | 1.0 | CCNE2 CCNE1 CDK2 | Cushing syndrome |
| REAC:R-HSA-187577 | 1.46159459799e-05 | 1.0 | CCNE2 CCNE1 CDK2 | SCF(Skp2)-mediated degradation of p27/p21 |
| KEGG:04218 | 1.49652172755e-05 | 1.0 | CCNE2 CCNE1 CDK2 | Cellular senescence |
| WP:WP179 | 1.63254441694e-05 | 1.0 | CCNE2 CCNE1 CDK2 | Cell Cycle |
| KEGG:05161 | 1.8304604287e-05 | 1.0 | CCNE2 CCNE1 CDK2 | Hepatitis B |
| REAC:R-HSA-69580 | 2.05735546476e-05 | 1.0 | CCNE2 CCNE1 CDK2 | p53-Dependent G1/S DNA damage checkpoint |
| REAC:R-HSA-69563 | 2.05735546476e-05 | 1.0 | CCNE2 CCNE1 CDK2 | p53-Dependent G1 DNA Damage Response |
| REAC:R-HSA-69615 | 2.2531998792e-05 | 1.0 | CCNE2 CCNE1 CDK2 | G1/S DNA Damage Checkpoints |
| REAC:R-HSA-69017 | 2.56967114485e-05 | 1.0 | CCNE2 CCNE1 CDK2 | CDK-mediated phosphorylation and removal of Cdc6 |
| KEGG:05169 | 3.02146485782e-05 | 1.0 | CCNE2 CCNE1 CDK2 | Epstein-Barr virus infection |
| KEGG:05203 | 3.27739581519e-05 | 1.0 | CCNE2 CCNE1 CDK2 | Viral carcinogenesis |
| REAC:R-HSA-2559586 | 3.55536741254e-05 | 1.0 | CCNE2 CCNE1 CDK2 | DNA Damage/Telomere Stress Induced Senescence |
| KEGG:05166 | 3.77375241277e-05 | 1.0 | CCNE2 CCNE1 CDK2 | Human T-cell leukemia virus 1 infection |
| REAC:R-HSA-69202 | 3.98163024387e-05 | 1.0 | CCNE2 CCNE1 CDK2 | Cyclin E associated events during G1/S transition |
| REAC:R-HSA-69656 | 4.28393920683e-05 | 1.0 | CCNE2 CCNE1 CDK2 | Cyclin A:Cdk2-associated events at S phase entry |
| REAC:R-HSA-69052 | 5.10580236014e-05 | 1.0 | CCNE2 CCNE1 CDK2 | Switching of origins to a post-replicative state |
| WP:WP53 | 6.3278776794e-05 | 0.666666666667 | CCNE1 CDK2 | ID signaling pathway |
| REAC:R-HSA-8849470 | 6.69449800487e-05 | 0.666666666667 | CCNE1 CDK2 | PTK6 Regulates Cell Cycle |
| CORUM:3015 | 9.39429153233e-05 | 0.666666666667 | CCNE1 CDK2 | p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex |
| REAC:R-HSA-69239 | 0.000120004609098 | 1.0 | CCNE2 CCNE1 CDK2 | Synthesis of DNA |
| KEGG:04151 | 0.00013397544306 | 1.0 | CCNE2 CCNE1 CDK2 | PI3K-Akt signaling pathway |
| REAC:R-HSA-69306 | 0.000146343794532 | 1.0 | CCNE2 CCNE1 CDK2 | DNA Replication |
| KEGG:05165 | 0.000150762444884 | 1.0 | CCNE2 CCNE1 CDK2 | Human papillomavirus infection |
| REAC:R-HSA-69206 | 0.000160847790881 | 1.0 | CCNE2 CCNE1 CDK2 | G1/S Transition |
| REAC:R-HSA-453279 | 0.000233190181847 | 1.0 | CCNE2 CCNE1 CDK2 | Mitotic G1-G1/S phases |
| WP:WP4172 | 0.000251129143237 | 1.0 | CCNE2 CCNE1 CDK2 | PI3K-Akt Signaling Pathway |
| REAC:R-HSA-69242 | 0.000295546575822 | 1.0 | CCNE2 CCNE1 CDK2 | S Phase |
| MIRNA:hsa-miR-524-5p | 0.00045403866007 | 1.0 | CCNE2 CCNE1 CDK2 | hsa-miR-524-5p |
| REAC:R-HSA-2559583 | 0.000489986899103 | 1.0 | CCNE2 CCNE1 CDK2 | Cellular Senescence |
| KEGG:05200 | 0.000500689425538 | 1.0 | CCNE2 CCNE1 CDK2 | Pathways in cancer |
| GO:0000307 | 0.000594407580071 | 1.0 | CCNE2 CCNE1 CDK2 | cyclin-dependent protein kinase holoenzyme complex |
| WP:WP2371 | 0.000603375431376 | 0.666666666667 | CCNE2 CCNE1 | Parkinsons Disease Pathway |
| WP:WP2516 | 0.000709588979832 | 0.666666666667 | CCNE1 CDK2 | ATM Signaling Pathway |
| GO:0097135 | 0.00135247023414 | 0.666666666667 | CCNE2 CDK2 | cyclin E2-CDK2 complex |
| REAC:R-HSA-69620 | 0.00175293114833 | 1.0 | CCNE2 CCNE1 CDK2 | Cell Cycle Checkpoints |
| WP:WP2032 | 0.00198950650794 | 0.666666666667 | CCNE1 CDK2 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| REAC:R-HSA-3700989 | 0.00313081125109 | 1.0 | CCNE2 CCNE1 CDK2 | Transcriptional Regulation by TP53 |
| WP:WP2261 | 0.00317409068183 | 0.666666666667 | CCNE1 CDK2 | Signaling Pathways in Glioblastoma |
| REAC:R-HSA-390471 | 0.0046992786316 | 0.666666666667 | CCNE2 CCNE1 | Association of TriC/CCT with target proteins during biosynthesis |
| MIRNA:hsa-miR-144-5p | 0.00499943519297 | 0.666666666667 | CCNE2 CCNE1 | hsa-miR-144-5p |
| REAC:R-HSA-2262752 | 0.00501472976187 | 1.0 | CCNE2 CCNE1 CDK2 | Cellular responses to stress |
| KEGG:05206 | 0.00544616782939 | 0.666666666667 | CCNE2 CCNE1 | MicroRNAs in cancer |
| GO:1902554 | 0.00588722337212 | 1.0 | CCNE2 CCNE1 CDK2 | serine/threonine protein kinase complex |
| REAC:R-HSA-9006927 | 0.00691608633843 | 0.666666666667 | CCNE1 CDK2 | Signaling by Non-Receptor Tyrosine Kinases |
| REAC:R-HSA-8848021 | 0.00691608633843 | 0.666666666667 | CCNE1 CDK2 | Signaling by PTK6 |
| WP:WP2877 | 0.00763160358706 | 0.666666666667 | CCNE1 CDK2 | Vitamin D Receptor Pathway |
| REAC:R-HSA-8953897 | 0.00865480168204 | 1.0 | CCNE2 CCNE1 CDK2 | Cellular responses to external stimuli |
| GO:1902911 | 0.00996606725847 | 1.0 | CCNE2 CCNE1 CDK2 | protein kinase complex |
| REAC:R-HSA-69278 | 0.0102351006549 | 1.0 | CCNE2 CCNE1 CDK2 | Cell Cycle, Mitotic |
| WP:WP4284 | 0.0142843877495 | 0.333333333333 | CCNE2 | Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer |
| REAC:R-HSA-1640170 | 0.0176005573074 | 1.0 | CCNE2 CCNE1 CDK2 | Cell Cycle |
| MIRNA:hsa-miR-892b | 0.0222508235814 | 0.666666666667 | CCNE1 CDK2 | hsa-miR-892b |
| REAC:R-HSA-390466 | 0.0267094284906 | 0.666666666667 | CCNE2 CCNE1 | Chaperonin-mediated protein folding |
| REAC:R-HSA-391251 | 0.0304025344128 | 0.666666666667 | CCNE2 CCNE1 | Protein folding |
| CORUM:5556 | 0.0499776345577 | 0.333333333333 | CDK2 | CDK2-CCNA2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CCNE1 | CDK2 | 1.0 | 0.949 | hein_WMM bioplex (CDK2) bioplex_WMM hein (CDK2) |
| CDK2 | CCNE2 | 0.992 | 0.915 | hein_WMM bioplex (CCNE2,CDK2) bioplex_WMM hein (CDK2) |
| CCNE1 | CCNE2 | 0.017 | 0.173 | hein_WMM bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05263 has an average edge precision of 0.679 which is ranked 1470 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CCNE1 | HuMAP2_01003 HuMAP2_04287 HuMAP2_05212 HuMAP2_05263 HuMAP2_06689 |
| CDK2 | HuMAP2_01003 HuMAP2_04287 HuMAP2_05212 HuMAP2_05263 HuMAP2_06056 HuMAP2_06689 |
| CCNE2 | HuMAP2_04287 HuMAP2_05212 HuMAP2_05263 HuMAP2_06056 |