hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05271
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AIFM1 | Apoptosis-inducing factor 1, mitochondrial (EC 1.1.1.-) (Programmed cell death protein 8) | UniProt NCBI |
| CHCHD4 | Mitochondrial intermembrane space import and assembly protein 40 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 4) | UniProt NCBI |
| TOR1AIP1 | Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) | UniProt NCBI |
| HEXB | Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A] | UniProt NCBI |
| PPIA | Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5843 | 6.70868171695e-06 | 0.4 | AIFM1 PPIA | AIF-CYPA-DNA complex |
| CORUM:6275 | 0.0249780992026 | 0.2 | HEXB | HEXB homodimer complex |
| KEGG:04217 | 0.0482876775804 | 0.4 | AIFM1 PPIA | Necroptosis |
| CORUM:6274 | 0.0499494897235 | 0.2 | HEXB | HEXA-HEXB complex |
| CORUM:7482 | 0.0499494897235 | 0.2 | TOR1AIP1 | LAP1-TOR1A complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PPIA | AIFM1 | 0.748 | 0.742 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| CHCHD4 | AIFM1 | 0.726 | 0.736 | hein_WMM bioplex (AIFM1) bioplex_WMM boldt youn_WMM hein (AIFM1) boldt_WMM |
| HEXB | PPIA | 0.123 | 0.395 | bioplex_WMM fraction |
| CHCHD4 | TOR1AIP1 | 0.042 | 0.269 | hein_WMM bioplex (TOR1AIP1) bioplex_WMM hein (TOR1AIP1) |
| AIFM1 | TOR1AIP1 | 0.037 | 0.268 | hein_WMM bioplex (AIFM1,TOR1AIP1) bioplex_WMM youn_WMM hein (TOR1AIP1) |
| HEXB | AIFM1 | 0.015 | 0.148 | bioplex_WMM fraction |
| PPIA | CHCHD4 | 0.007 | 0.016 | bioplex_WMM boldt youn_WMM boldt_WMM |
| PPIA | TOR1AIP1 | 0.007 | 0.006 | hein_WMM bioplex (TOR1AIP1) bioplex_WMM youn_WMM gupta_WMM |
| HEXB | CHCHD4 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| HEXB | TOR1AIP1 | 0.007 | 0.002 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05271 has an average edge precision of 0.259 which is ranked 5250 out of all 6965 complexes.
Related Complexes