hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05272
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NLRP5 | NACHT, LRR and PYD domains-containing protein 5 (Mater protein homolog) | UniProt NCBI |
| UGP2 | UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (UDP-glucose pyrophosphorylase) (UDPGP) (UGPase) | UniProt NCBI |
| PFKP | ATP-dependent 6-phosphofructokinase, platelet type (ATP-PFK) (PFK-P) (EC 2.7.1.11) (6-phosphofructokinase type C) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphohexokinase) | UniProt NCBI |
| RBKS | Ribokinase (RK) (EC 2.7.1.15) | UniProt NCBI |
| ASPDH | Putative L-aspartate dehydrogenase (EC 1.4.1.21) (Aspartate dehydrogenase domain-containing protein) | UniProt NCBI |
| PFKL | ATP-dependent 6-phosphofructokinase, liver type (ATP-PFK) (PFK-L) (EC 2.7.1.11) (6-phosphofructokinase type B) (Phosphofructo-1-kinase isozyme B) (PFK-B) (Phosphohexokinase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00052 | 4.90152231578e-06 | 0.5 | PFKL UGP2 PFKP | Galactose metabolism |
| KEGG:00030 | 6.12128026672e-06 | 0.5 | PFKL PFKP RBKS | Pentose phosphate pathway |
| REAC:R-HSA-71387 | 0.000223864296418 | 0.666666666667 | PFKL RBKS UGP2 PFKP | Metabolism of carbohydrates |
| KEGG:01100 | 0.0012193073463 | 0.833333333333 | PFKL RBKS UGP2 ASPDH PFKP | Metabolic pathways |
| GO:0019200 | 0.00240920978697 | 0.5 | PFKL PFKP RBKS | carbohydrate kinase activity |
| KEGG:00051 | 0.0032877278217 | 0.333333333333 | PFKL PFKP | Fructose and mannose metabolism |
| WP:WP534 | 0.00524729006009 | 0.333333333333 | PFKL PFKP | Glycolysis and Gluconeogenesis |
| KEGG:00010 | 0.0120956152943 | 0.333333333333 | PFKL PFKP | Glycolysis / Gluconeogenesis |
| KEGG:05230 | 0.013683677248 | 0.333333333333 | PFKL PFKP | Central carbon metabolism in cancer |
| KEGG:01230 | 0.0153684049392 | 0.333333333333 | PFKL PFKP | Biosynthesis of amino acids |
| WP:WP4018 | 0.0174151198914 | 0.333333333333 | PFKL PFKP | Pathways in clear cell renal cell carcinoma |
| KEGG:03018 | 0.0176099294651 | 0.333333333333 | PFKL PFKP | RNA degradation |
| GO:0003872 | 0.020283420769 | 0.333333333333 | PFKL PFKP | 6-phosphofructokinase activity |
| GO:0005945 | 0.020283420769 | 0.333333333333 | PFKL PFKP | 6-phosphofructokinase complex |
| KEGG:04922 | 0.0280749165362 | 0.333333333333 | PFKL PFKP | Glucagon signaling pathway |
| KEGG:04066 | 0.0304541793376 | 0.333333333333 | PFKL PFKP | HIF-1 signaling pathway |
| KEGG:04152 | 0.0381607333212 | 0.333333333333 | PFKL PFKP | AMPK signaling pathway |
| KEGG:01200 | 0.039527830217 | 0.333333333333 | PFKL PFKP | Carbon metabolism |
| GO:0070095 | 0.0405595771497 | 0.333333333333 | PFKL PFKP | fructose-6-phosphate binding |
| REAC:R-HSA-70171 | 0.0470157324282 | 0.333333333333 | PFKL PFKP | Glycolysis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PFKP | PFKL | 0.47 | 0.605 | hein_WMM bioplex (PFKL,PFKP) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| UGP2 | PFKP | 0.087 | 0.353 | fraction treiber_WMM |
| UGP2 | RBKS | 0.081 | 0.351 | fraction |
| ASPDH | RBKS | 0.057 | 0.317 | fraction |
| UGP2 | PFKL | 0.046 | 0.293 | fraction treiber_WMM |
| UGP2 | NLRP5 | 0.037 | 0.264 | fraction |
| UGP2 | ASPDH | 0.029 | 0.232 | fraction |
| ASPDH | PFKL | 0.005 | 0.011 | bioplex (ASPDH) |
Images
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Complex HuMAP2_05272 has an average edge precision of 0.303 which is ranked 4534 out of all 6965 complexes.
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