hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05273
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NDUFAF4 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 (Hormone-regulated proliferation-associated protein of 20 kDa) | UniProt NCBI |
| NDUFA13 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (Cell death regulatory protein GRIM-19) (Complex I-B16.6) (CI-B16.6) (Gene associated with retinoic and interferon-induced mortality 19 protein) (GRIM-19) (Gene associated with retinoic and IFN-induced mortality 19 protein) (NADH-ubiquinone oxidoreductase B16.6 subunit) | UniProt NCBI |
| ERCC8 | DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA) | UniProt NCBI |
| NDUFA1 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (Complex I-MWFE) (CI-MWFE) (NADH-ubiquinone oxidoreductase MWFE subunit) | UniProt NCBI |
| NDUFA3 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (Complex I-B9) (CI-B9) (NADH-ubiquinone oxidoreductase B9 subunit) | UniProt NCBI |
| NDUFA8 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (Complex I-19kD) (CI-19kD) (Complex I-PGIV) (CI-PGIV) (NADH-ubiquinone oxidoreductase 19 kDa subunit) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4324 | 1.16256677607e-10 | 0.833333333333 | NDUFAF4 NDUFA13 NDUFA8 NDUFA1 NDUFA3 | Mitochondrial complex I assembly model OXPHOS system |
| REAC:R-HSA-6799198 | 4.17727607273e-10 | 0.833333333333 | NDUFAF4 NDUFA13 NDUFA8 NDUFA1 NDUFA3 | Complex I biogenesis |
| REAC:R-HSA-611105 | 8.80177087213e-09 | 0.833333333333 | NDUFAF4 NDUFA13 NDUFA8 NDUFA1 NDUFA3 | Respiratory electron transport |
| REAC:R-HSA-163200 | 2.56866165763e-08 | 0.833333333333 | NDUFAF4 NDUFA13 NDUFA8 NDUFA1 NDUFA3 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| CORUM:178 | 4.13317785278e-08 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | Respiratory chain complex I (holoenzyme), mitochondrial |
| KEGG:04714 | 1.42477469986e-07 | 0.833333333333 | NDUFAF4 NDUFA13 NDUFA8 NDUFA1 NDUFA3 | Thermogenesis |
| REAC:R-HSA-1428517 | 1.53110819373e-07 | 0.833333333333 | NDUFAF4 NDUFA13 NDUFA8 NDUFA1 NDUFA3 | The citric acid (TCA) cycle and respiratory electron transport |
| CORUM:2919 | 2.7014158649e-07 | 0.5 | NDUFA8 NDUFA1 NDUFA3 | Respiratory chain complex I (gamma subunit) mitochondrial |
| GO:0010257 | 2.91493398728e-07 | 0.833333333333 | NDUFAF4 NDUFA13 NDUFA8 NDUFA1 NDUFA3 | NADH dehydrogenase complex assembly |
| GO:0032981 | 2.91493398728e-07 | 0.833333333333 | NDUFAF4 NDUFA13 NDUFA8 NDUFA1 NDUFA3 | mitochondrial respiratory chain complex I assembly |
| GO:0033108 | 2.14989853687e-06 | 0.833333333333 | NDUFAF4 NDUFA13 NDUFA8 NDUFA1 NDUFA3 | mitochondrial respiratory chain complex assembly |
| KEGG:00190 | 2.56835422091e-06 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | Oxidative phosphorylation |
| KEGG:05012 | 3.34705576874e-06 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | Parkinson disease |
| KEGG:04723 | 4.03786746906e-06 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | Retrograde endocannabinoid signaling |
| KEGG:04932 | 4.16262235351e-06 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | Non-alcoholic fatty liver disease (NAFLD) |
| WP:WP4396 | 4.18673313073e-06 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | Nonalcoholic fatty liver disease |
| KEGG:05010 | 7.51229021242e-06 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | Alzheimer disease |
| KEGG:05016 | 1.28484416656e-05 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | Huntington disease |
| GO:0003954 | 2.69127816091e-05 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | NADH dehydrogenase activity |
| GO:0008137 | 2.69127816091e-05 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | NADH dehydrogenase (ubiquinone) activity |
| GO:0050136 | 2.69127816091e-05 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | NADH dehydrogenase (quinone) activity |
| GO:0005747 | 4.94625447876e-05 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | mitochondrial respiratory chain complex I |
| GO:0030964 | 4.94625447876e-05 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | NADH dehydrogenase complex |
| GO:0045271 | 4.94625447876e-05 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | respiratory chain complex I |
| GO:0006120 | 5.42823133593e-05 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | mitochondrial electron transport, NADH to ubiquinone |
| GO:0016655 | 9.85570254489e-05 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor |
| HP:0011400 | 0.000176391876177 | 0.666666666667 | NDUFAF4 NDUFA13 NDUFA1 ERCC8 | Abnormal CNS myelination |
| WP:WP111 | 0.000192159737634 | 0.5 | NDUFA8 NDUFA1 NDUFA3 | Electron Transport Chain (OXPHOS system in mitochondria) |
| GO:0098803 | 0.000295964852823 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | respiratory chain complex |
| GO:0005746 | 0.000314144203038 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | mitochondrial respirasome |
| GO:0070469 | 0.000395345440439 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | respirasome |
| HP:0001138 | 0.000442726382359 | 0.5 | NDUFA13 NDUFA1 NDUFAF4 | Optic neuropathy |
| GO:0042775 | 0.000517834485544 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | mitochondrial ATP synthesis coupled electron transport |
| GO:0042773 | 0.000545393489246 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | ATP synthesis coupled electron transport |
| HP:0008972 | 0.000720000789919 | 0.5 | NDUFA13 NDUFA1 NDUFAF4 | Decreased activity of mitochondrial respiratory chain |
| HP:0011922 | 0.000756496387193 | 0.5 | NDUFA13 NDUFA1 NDUFAF4 | Abnormal activity of mitochondrial respiratory chain |
| GO:0016651 | 0.000770248195723 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | oxidoreductase activity, acting on NAD(P)H |
| HP:0000817 | 0.00079420087652 | 0.5 | NDUFA13 NDUFA1 NDUFAF4 | Poor eye contact |
| GO:1990204 | 0.00084563217517 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | oxidoreductase complex |
| GO:0022904 | 0.000968898210955 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | respiratory electron transport chain |
| GO:0022900 | 0.00101282970404 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | electron transport chain |
| HP:0002490 | 0.00124200653741 | 0.5 | NDUFA13 NDUFA1 NDUFAF4 | Increased CSF lactate |
| HP:0030085 | 0.00124200653741 | 0.5 | NDUFA13 NDUFA1 NDUFAF4 | Abnormal CSF lactate level |
| HP:0000735 | 0.00183201380014 | 0.5 | NDUFA13 NDUFA1 NDUFAF4 | Impaired social interactions |
| HP:0025454 | 0.00211215101544 | 0.5 | NDUFA13 NDUFA1 NDUFAF4 | Abnormal CSF metabolite level |
| GO:0005743 | 0.00232803219041 | 0.833333333333 | NDUFAF4 NDUFA13 NDUFA8 NDUFA1 NDUFA3 | mitochondrial inner membrane |
| GO:0098800 | 0.0024130539346 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | inner mitochondrial membrane protein complex |
| HP:0002415 | 0.00266824580105 | 0.5 | NDUFA13 NDUFA1 NDUFAF4 | Leukodystrophy |
| GO:0006119 | 0.0028699930952 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | oxidative phosphorylation |
| HP:0012447 | 0.00310019879735 | 0.666666666667 | NDUFAF4 NDUFA13 NDUFA1 ERCC8 | Abnormal myelination |
| GO:0019866 | 0.00343452854206 | 0.833333333333 | NDUFAF4 NDUFA13 NDUFA8 NDUFA1 NDUFA3 | organelle inner membrane |
| HP:0002921 | 0.00373876477543 | 0.666666666667 | NDUFAF4 NDUFA13 NDUFA1 ERCC8 | Abnormality of the cerebrospinal fluid |
| HP:0011017 | 0.00417431131054 | 0.666666666667 | NDUFAF4 NDUFA13 NDUFA1 ERCC8 | Abnormal cellular physiology |
| HP:0025354 | 0.00460204819931 | 0.666666666667 | NDUFAF4 NDUFA13 NDUFA1 ERCC8 | Abnormal cellular phenotype |
| HP:0003287 | 0.00542992690819 | 0.5 | NDUFA13 NDUFA1 NDUFAF4 | Abnormality of mitochondrial metabolism |
| GO:0007005 | 0.00548046545087 | 0.833333333333 | NDUFAF4 NDUFA13 NDUFA8 NDUFA1 NDUFA3 | mitochondrion organization |
| HP:0012433 | 0.00614519903403 | 0.5 | NDUFA13 NDUFA1 NDUFAF4 | Abnormal social behavior |
| GO:0045333 | 0.0061921234234 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | cellular respiration |
| HP:0002421 | 0.00758494304221 | 0.5 | NDUFA13 NDUFA1 NDUFAF4 | Poor head control |
| WP:WP623 | 0.00822079355503 | 0.333333333333 | NDUFA3 NDUFA8 | Oxidative phosphorylation |
| HP:0012103 | 0.00923202229008 | 0.5 | NDUFA13 NDUFA1 NDUFAF4 | Abnormality of the mitochondrion |
| GO:0031966 | 0.0109160303478 | 0.833333333333 | NDUFAF4 NDUFA13 NDUFA8 NDUFA1 NDUFA3 | mitochondrial membrane |
| HP:0012795 | 0.0118416310867 | 0.666666666667 | NDUFAF4 NDUFA13 NDUFA1 ERCC8 | Abnormality of the optic disc |
| GO:0044455 | 0.0148506630994 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | mitochondrial membrane part |
| GO:0005740 | 0.0151221141199 | 0.833333333333 | NDUFAF4 NDUFA13 NDUFA8 NDUFA1 NDUFA3 | mitochondrial envelope |
| HP:0000587 | 0.022450793933 | 0.666666666667 | NDUFAF4 NDUFA13 NDUFA1 ERCC8 | Abnormality of the optic nerve |
| GO:0015980 | 0.023174580771 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | energy derivation by oxidation of organic compounds |
| REAC:R-HSA-1430728 | 0.0278608311428 | 0.833333333333 | NDUFAF4 NDUFA13 NDUFA8 NDUFA1 NDUFA3 | Metabolism |
| HP:0012748 | 0.032521154219 | 0.333333333333 | NDUFAF4 NDUFA1 | Focal T2 hyperintense brainstem lesion |
| HPA:026020_03 | 0.03297273154 | 0.5 | NDUFA13 NDUFA3 NDUFAF4 | liver; hepatocytes[Uncertain,High] |
| KEGG:01100 | 0.0331288091988 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | Metabolic pathways |
| HP:0001639 | 0.033266345548 | 0.5 | NDUFA13 NDUFA1 NDUFAF4 | Hypertrophic cardiomyopathy |
| HP:0008316 | 0.034757762481 | 0.333333333333 | NDUFAF4 NDUFA1 | Abnormal mitochondria in muscle tissue |
| HP:0000486 | 0.0371616198508 | 0.666666666667 | NDUFAF4 NDUFA13 NDUFA1 ERCC8 | Strabismus |
| HP:0001251 | 0.0392952022063 | 0.666666666667 | NDUFAF4 NDUFA13 NDUFA1 ERCC8 | Ataxia |
| HP:0012747 | 0.0419110169922 | 0.333333333333 | NDUFAF4 NDUFA1 | Abnormal brainstem MRI signal intensity |
| HP:0000549 | 0.0424327328427 | 0.666666666667 | NDUFAF4 NDUFA13 NDUFA1 ERCC8 | Abnormal conjugate eye movement |
| GO:0098798 | 0.0434575095048 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | mitochondrial protein complex |
| HP:0011923 | 0.044443111782 | 0.333333333333 | NDUFAF4 NDUFA1 | Decreased activity of mitochondrial complex I |
| HP:0025116 | 0.044443111782 | 0.333333333333 | NDUFAF4 NDUFA1 | Fetal distress |
| HP:0007704 | 0.044443111782 | 0.333333333333 | NDUFAF4 NDUFA1 | Paroxysmal involuntary eye movements |
| HP:0001324 | 0.0455085239677 | 0.666666666667 | NDUFAF4 NDUFA13 NDUFA1 ERCC8 | Muscle weakness |
| GO:0046034 | 0.0457293961323 | 0.666666666667 | NDUFA13 NDUFA8 NDUFA1 NDUFA3 | ATP metabolic process |
| HP:0000114 | 0.0497285764978 | 0.333333333333 | NDUFAF4 NDUFA1 | Proximal tubulopathy |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NDUFA8 | NDUFA1 | 0.549 | 0.643 | bioplex (NDUFA8) bioplex_WMM |
| NDUFA8 | NDUFA3 | 0.191 | 0.443 | bioplex (NDUFA8) bioplex_WMM boldt boldt_WMM |
| ERCC8 | NDUFA13 | 0.103 | 0.366 | bioplex (NDUFA13) bioplex_WMM |
| NDUFA8 | NDUFA13 | 0.091 | 0.354 | hein_WMM bioplex (NDUFA13,NDUFA8) bioplex_WMM boldt boldt_WMM |
| NDUFA3 | NDUFA13 | 0.091 | 0.354 | bioplex (NDUFA13) bioplex_WMM boldt boldt_WMM |
| NDUFAF4 | NDUFA13 | 0.059 | 0.328 | bioplex (NDUFA13) bioplex_WMM boldt boldt_WMM |
| NDUFA3 | NDUFA1 | 0.009 | 0.1 | bioplex_WMM WMM_only |
| NDUFA13 | NDUFA1 | 0.009 | 0.097 | bioplex_WMM WMM_only |
| NDUFA8 | ERCC8 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| NDUFAF4 | NDUFA1 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| NDUFA3 | ERCC8 | 0.007 | 0.008 | bioplex_WMM WMM_only |
| ERCC8 | NDUFAF4 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| NDUFA3 | NDUFAF4 | 0.006 | 0.003 | bioplex_WMM WMM_only |
| NDUFA8 | NDUFAF4 | 0.0 | 0.011 | bioplex (NDUFA8) bioplex_WMM boldt boldt_WMM |
Images
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Complex HuMAP2_05273 has an average edge precision of 0.194 which is ranked 6253 out of all 6965 complexes.
Related Complexes