hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05282
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PITX2 | Pituitary homeobox 2 (ALL1-responsive protein ARP1) (Homeobox protein PITX2) (Paired-like homeodomain transcription factor 2) (RIEG bicoid-related homeobox transcription factor) (Solurshin) | UniProt NCBI |
| AHCYL1 | S-adenosylhomocysteine hydrolase-like protein 1 (DC-expressed AHCY-like molecule) (IP(3)Rs binding protein released with IP(3)) (IRBIT) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2) | UniProt NCBI |
| FAM13C | Protein FAM13C | UniProt NCBI |
| JOSD2 | Josephin-2 (EC 3.4.19.12) (Josephin domain-containing protein 2) | UniProt NCBI |
| AHCYL2 | Adenosylhomocysteinase 3 (AdoHcyase 3) (EC 3.3.1.1) (IP(3)Rs binding protein released with IP(3) 2) (IRBIT2) (Long-IRBIT) (S-adenosyl-L-homocysteine hydrolase 3) (S-adenosylhomocysteine hydrolase-like protein 2) | UniProt NCBI |
| ZIC2 | Zinc finger protein ZIC 2 (Zinc finger protein of the cerebellum 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2525 | 0.00241892882621 | 0.333333333333 | AHCYL1 AHCYL2 | Trans-sulfuration and one carbon metabolism |
| KEGG:00270 | 0.00642969194212 | 0.333333333333 | AHCYL1 AHCYL2 | Cysteine and methionine metabolism |
| GO:0033353 | 0.0405595771497 | 0.333333333333 | AHCYL1 AHCYL2 | S-adenosylmethionine cycle |
| WP:WP2857 | 0.045101111668 | 0.333333333333 | PITX2 ZIC2 | Mesodermal Commitment Pathway |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| AHCYL2 | AHCYL1 | 0.999 | 0.949 | bioplex (AHCYL2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| JOSD2 | AHCYL2 | 0.175 | 0.434 | bioplex (JOSD2) bioplex_WMM |
| ZIC2 | AHCYL2 | 0.108 | 0.372 | bioplex (AHCYL2) bioplex_WMM |
| PITX2 | AHCYL2 | 0.108 | 0.372 | bioplex (AHCYL2,PITX2) bioplex_WMM youn_WMM |
| AHCYL2 | FAM13C | 0.096 | 0.359 | bioplex (FAM13C) bioplex_WMM |
| JOSD2 | AHCYL1 | 0.064 | 0.347 | bioplex (JOSD2) bioplex_WMM |
| ZIC2 | PITX2 | 0.008 | 0.04 | bioplex_WMM WMM_only |
| ZIC2 | AHCYL1 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| AHCYL1 | FAM13C | 0.006 | 0.007 | bioplex (FAM13C) bioplex_WMM |
| PITX2 | AHCYL1 | 0.0 | 0.013 | bioplex (PITX2) bioplex_WMM |
Images
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Complex HuMAP2_05282 has an average edge precision of 0.29 which is ranked 4755 out of all 6965 complexes.
Related Complexes