hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05288
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ATP6V1A | V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar ATPase isoform VA68) (Vacuolar proton pump subunit alpha) | UniProt NCBI |
| PFKP | ATP-dependent 6-phosphofructokinase, platelet type (ATP-PFK) (PFK-P) (EC 2.7.1.11) (6-phosphofructokinase type C) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphohexokinase) | UniProt NCBI |
| PFKM | ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC 2.7.1.11) (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase) | UniProt NCBI |
| PFKL | ATP-dependent 6-phosphofructokinase, liver type (ATP-PFK) (PFK-L) (EC 2.7.1.11) (6-phosphofructokinase type B) (Phosphofructo-1-kinase isozyme B) (PFK-B) (Phosphohexokinase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0003872 | 3.63274304092e-07 | 0.75 | PFKL PFKP PFKM | 6-phosphofructokinase activity |
| GO:0005945 | 3.63274304092e-07 | 0.75 | PFKL PFKP PFKM | 6-phosphofructokinase complex |
| KEGG:00052 | 7.86142898641e-07 | 0.75 | PFKL PFKP PFKM | Galactose metabolism |
| KEGG:00030 | 9.81974852015e-07 | 0.75 | PFKL PFKP PFKM | Pentose phosphate pathway |
| GO:0070095 | 1.45302402969e-06 | 0.75 | PFKL PFKP PFKM | fructose-6-phosphate binding |
| KEGG:00051 | 1.46594800298e-06 | 0.75 | PFKL PFKP PFKM | Fructose and mannose metabolism |
| WP:WP534 | 2.98215510426e-06 | 0.75 | PFKL PFKP PFKM | Glycolysis and Gluconeogenesis |
| KEGG:00010 | 1.06536230694e-05 | 0.75 | PFKL PFKP PFKM | Glycolysis / Gluconeogenesis |
| GO:0008443 | 1.27120391093e-05 | 0.75 | PFKL PFKP PFKM | phosphofructokinase activity |
| KEGG:05230 | 1.28493032652e-05 | 0.75 | PFKL PFKP PFKM | Central carbon metabolism in cancer |
| KEGG:01230 | 1.5327283042e-05 | 0.75 | PFKL PFKP PFKM | Biosynthesis of amino acids |
| WP:WP4018 | 1.84663765394e-05 | 0.75 | PFKL PFKP PFKM | Pathways in clear cell renal cell carcinoma |
| KEGG:03018 | 1.88476199198e-05 | 0.75 | PFKL PFKP PFKM | RNA degradation |
| GO:0016208 | 3.05058200216e-05 | 0.75 | PFKL PFKP PFKM | AMP binding |
| KEGG:04922 | 3.82677846902e-05 | 0.75 | PFKL PFKP PFKM | Glucagon signaling pathway |
| KEGG:04066 | 4.32996100123e-05 | 0.75 | PFKL PFKP PFKM | HIF-1 signaling pathway |
| GO:0006002 | 4.35775472874e-05 | 0.75 | PFKL PFKP PFKM | fructose 6-phosphate metabolic process |
| GO:0030388 | 4.35775472874e-05 | 0.75 | PFKL PFKP PFKM | fructose 1,6-bisphosphate metabolic process |
| KEGG:04152 | 6.09947630131e-05 | 0.75 | PFKL PFKP PFKM | AMPK signaling pathway |
| REAC:R-HSA-70171 | 6.16010596593e-05 | 0.75 | PFKL PFKP PFKM | Glycolysis |
| KEGG:01200 | 6.43452048828e-05 | 0.75 | PFKL PFKP PFKM | Carbon metabolism |
| REAC:R-HSA-70326 | 0.000119121057505 | 0.75 | PFKL PFKP PFKM | Glucose metabolism |
| GO:0019200 | 0.000482716802139 | 0.75 | PFKL PFKP PFKM | carbohydrate kinase activity |
| GO:0061615 | 0.00106129291317 | 0.75 | PFKL PFKP PFKM | glycolytic process through fructose-6-phosphate |
| GO:0061621 | 0.00106129291317 | 0.75 | PFKL PFKP PFKM | canonical glycolysis |
| GO:0061718 | 0.00106129291317 | 0.75 | PFKL PFKP PFKM | glucose catabolic process to pyruvate |
| GO:0006735 | 0.00106129291317 | 0.75 | PFKL PFKP PFKM | NADH regeneration |
| GO:0061620 | 0.00106129291317 | 0.75 | PFKL PFKP PFKM | glycolytic process through glucose-6-phosphate |
| GO:0006007 | 0.00147288799354 | 0.75 | PFKL PFKP PFKM | glucose catabolic process |
| GO:0048029 | 0.00179920875514 | 0.75 | PFKL PFKP PFKM | monosaccharide binding |
| KEGG:01100 | 0.00203701694021 | 1.0 | PFKM PFKL PFKP ATP6V1A | Metabolic pathways |
| GO:0006734 | 0.00237379826551 | 0.75 | PFKL PFKP PFKM | NADH metabolic process |
| GO:0019674 | 0.00358246159338 | 0.75 | PFKL PFKP PFKM | NAD metabolic process |
| REAC:R-HSA-71387 | 0.00394951473773 | 0.75 | PFKL PFKP PFKM | Metabolism of carbohydrates |
| GO:0019320 | 0.0062689516986 | 0.75 | PFKL PFKP PFKM | hexose catabolic process |
| GO:0046365 | 0.0100430829723 | 0.75 | PFKL PFKP PFKM | monosaccharide catabolic process |
| GO:0051289 | 0.0181462528862 | 0.75 | PFKL PFKP PFKM | protein homotetramerization |
| WP:WP481 | 0.0195247658454 | 0.5 | PFKL PFKM | Insulin Signaling |
| GO:0030246 | 0.0254442868917 | 0.75 | PFKL PFKP PFKM | carbohydrate binding |
| GO:0070061 | 0.0270421395626 | 0.5 | PFKL PFKM | fructose binding |
| GO:0006096 | 0.0469269676219 | 0.75 | PFKL PFKP PFKM | glycolytic process |
| GO:0006757 | 0.0484715579516 | 0.75 | PFKL PFKP PFKM | ATP generation from ADP |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PFKL | PFKM | 0.993 | 0.918 | bioplex (PFKL) bioplex_WMM youn_WMM Malo gupta_WMM fraction treiber_WMM |
| PFKP | PFKL | 0.47 | 0.605 | hein_WMM bioplex (PFKL,PFKP) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| PFKP | ATP6V1A | 0.127 | 0.398 | Guru boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| PFKL | ATP6V1A | 0.052 | 0.304 | Guru boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| ATP6V1A | PFKM | 0.051 | 0.301 | Guru youn_WMM gupta_WMM fraction treiber_WMM |
| PFKP | PFKM | 0.009 | 0.097 | bioplex (PFKP) bioplex_WMM youn_WMM gupta_WMM treiber_WMM |
Images
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Complex HuMAP2_05288 has an average edge precision of 0.437 which is ranked 2958 out of all 6965 complexes.
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