hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_05290
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha) | UniProt NCBI |
| PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta) | UniProt NCBI |
| PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4582 | 7.72924051261e-09 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Cancer immunotherapy by CTLA4 blockade |
| REAC:R-HSA-198203 | 2.51774270163e-08 | 1.0 | PIK3R1 PIK3R2 PIK3CB | PI3K/AKT activation |
| REAC:R-HSA-2730905 | 5.39516293207e-08 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Role of LAT2/NTAL/LAB on calcium mobilization |
| KEGG:04960 | 1.35175330869e-07 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Aldosterone-regulated sodium reabsorption |
| REAC:R-HSA-210993 | 2.04566594508e-07 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Tie2 Signaling |
| WP:WP3844 | 2.61505970677e-07 | 1.0 | PIK3R1 PIK3R2 PIK3CB | PI3K-AKT-mTOR signaling pathway and therapeutic opportunities |
| WP:WP3937 | 2.61505970677e-07 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Microglia Pathogen Phagocytosis Pathway |
| KEGG:04973 | 2.97115076526e-07 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Carbohydrate digestion and absorption |
| REAC:R-HSA-912526 | 3.05725899484e-07 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Interleukin receptor SHC signaling |
| KEGG:04930 | 3.9827854995e-07 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Type II diabetes mellitus |
| KEGG:04923 | 3.9827854995e-07 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Regulation of lipolysis in adipocytes |
| REAC:R-HSA-912631 | 5.12540478546e-07 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Regulation of signaling by CBL |
| REAC:R-HSA-2029485 | 5.97963891637e-07 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Role of phospholipids in phagocytosis |
| REAC:R-HSA-2424491 | 5.97963891637e-07 | 1.0 | PIK3R1 PIK3R2 PIK3CB | DAP12 signaling |
| REAC:R-HSA-373753 | 6.92379242949e-07 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Nephrin family interactions |
| KEGG:04929 | 7.45915218436e-07 | 1.0 | PIK3R1 PIK3R2 PIK3CB | GnRH secretion |
| KEGG:04664 | 7.88948788731e-07 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Fc epsilon RI signaling pathway |
| KEGG:04370 | 7.88948788731e-07 | 1.0 | PIK3R1 PIK3R2 PIK3CB | VEGF signaling pathway |
| KEGG:04213 | 8.33606267338e-07 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Longevity regulating pathway - multiple species |
| KEGG:05213 | 8.79917726635e-07 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Endometrial cancer |
| REAC:R-HSA-2172127 | 9.09984147875e-07 | 1.0 | PIK3R1 PIK3R2 PIK3CB | DAP12 interactions |
| WP:WP4566 | 9.77748924845e-07 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Translation inhibitors in chronically activated PDGFRA cells |
| KEGG:05221 | 1.02907671242e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Acute myeloid leukemia |
| WP:WP4539 | 1.04441362427e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Synaptic signaling pathways associated with autism spectrum disorder |
| KEGG:04917 | 1.13733726662e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Prolactin signaling pathway |
| KEGG:05218 | 1.13733726662e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Melanoma |
| KEGG:05211 | 1.19420412995e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Renal cell carcinoma |
| KEGG:05223 | 1.25293548061e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Non-small cell lung cancer |
| REAC:R-HSA-109704 | 1.31507096469e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | PI3K Cascade |
| REAC:R-HSA-186763 | 1.31507096469e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Downstream signal transduction |
| KEGG:05230 | 1.44061718026e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Central carbon metabolism in cancer |
| KEGG:04662 | 1.44061718026e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | B cell receptor signaling pathway |
| REAC:R-HSA-114604 | 1.47287948045e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | GPVI-mediated activation cascade |
| KEGG:05214 | 1.50710720397e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Glioma |
| KEGG:05212 | 1.7187866598e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Pancreatic cancer |
| KEGG:01524 | 1.79351651458e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Platinum drug resistance |
| KEGG:05100 | 1.87038150806e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Bacterial invasion of epithelial cells |
| WP:WP4205 | 1.88464647832e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | MET in type 1 papillary renal cell carcinoma |
| KEGG:05220 | 1.94941171262e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Chronic myeloid leukemia |
| KEGG:01521 | 1.94941171262e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | EGFR tyrosine kinase inhibitor resistance |
| REAC:R-HSA-112399 | 2.02093811497e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | IRS-mediated signalling |
| REAC:R-HSA-8853659 | 2.02093811497e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | RET signaling |
| REAC:R-HSA-451927 | 2.23000067859e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Interleukin-2 family signaling |
| KEGG:04012 | 2.37809343488e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | ErbB signaling pathway |
| WP:WP4155 | 2.43599896822e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Endometrial cancer |
| KEGG:05235 | 2.47074642585e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| KEGG:04914 | 2.56577513453e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Progesterone-mediated oocyte maturation |
| KEGG:04750 | 2.56577513453e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Inflammatory mediator regulation of TRP channels |
| KEGG:05210 | 2.66320963331e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Colorectal cancer |
| KEGG:04211 | 2.66320963331e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Longevity regulating pathway |
| WP:WP1403 | 2.68359230598e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | AMP-activated Protein Kinase (AMPK) Signaling |
| REAC:R-HSA-2428928 | 2.69038791546e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | IRS-related events triggered by IGF1R |
| REAC:R-HSA-2428924 | 2.69038791546e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | IGF1R signaling cascade |
| REAC:R-HSA-2404192 | 2.94261178253e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| KEGG:05146 | 2.97024859397e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Amoebiasis |
| KEGG:04620 | 3.07760697689e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Toll-like receptor signaling pathway |
| REAC:R-HSA-74751 | 3.21012194458e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Insulin receptor signalling cascade |
| KEGG:04666 | 3.30002227102e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Fc gamma R-mediated phagocytosis |
| KEGG:04625 | 3.30002227102e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | C-type lectin receptor signaling pathway |
| KEGG:05142 | 3.30002227102e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Chagas disease (American trypanosomiasis) |
| KEGG:04670 | 3.30002227102e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Leukocyte transendothelial migration |
| KEGG:05231 | 3.41513932698e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Choline metabolism in cancer |
| REAC:R-HSA-512988 | 3.49336799851e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| WP:WP4255 | 3.5258218805e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Non-small cell lung cancer |
| KEGG:04660 | 3.53290275205e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | T cell receptor signaling pathway |
| KEGG:01522 | 3.53290275205e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Endocrine resistance |
| KEGG:05215 | 3.53290275205e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Prostate cancer |
| KEGG:04933 | 3.6533426186e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | AGE-RAGE signaling pathway in diabetic complications |
| KEGG:05222 | 3.776488999e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Small cell lung cancer |
| KEGG:04070 | 3.776488999e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Phosphatidylinositol signaling system |
| KEGG:04668 | 3.90237196563e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | TNF signaling pathway |
| WP:WP2037 | 4.17533572491e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Prolactin Signaling Pathway |
| KEGG:04725 | 4.29674110668e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Cholinergic synapse |
| WP:WP1544 | 4.52804673364e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | MicroRNAs in cardiomyocyte hypertrophy |
| KEGG:04650 | 4.71682212935e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Natural killer cell mediated cytotoxicity |
| KEGG:04066 | 4.86270322614e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | HIF-1 signaling pathway |
| KEGG:04931 | 5.1634269878e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Insulin resistance |
| KEGG:04380 | 5.31832979744e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Osteoclast differentiation |
| WP:WP2261 | 5.7041794983e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Signaling Pathways in Glioblastoma |
| WP:WP4263 | 5.91808622949e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Pancreatic adenocarcinoma pathway |
| KEGG:04722 | 5.96891558343e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Neurotrophin signaling pathway |
| KEGG:04071 | 6.31321421816e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Sphingolipid signaling pathway |
| WP:WP673 | 6.36180904525e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | ErbB Signaling Pathway |
| REAC:R-HSA-2219530 | 6.37978016717e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Constitutive Signaling by Aberrant PI3K in Cancer |
| KEGG:04611 | 6.67050411939e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Platelet activation |
| KEGG:05135 | 6.85409597589e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Yersinia infection |
| KEGG:04152 | 6.85409597589e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | AMPK signaling pathway |
| KEGG:04919 | 7.04102586614e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Thyroid hormone signaling pathway |
| WP:WP75 | 7.06813280743e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Toll-like Receptor Signaling Pathway |
| KEGG:04068 | 7.23132386252e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | FoxO signaling pathway |
| REAC:R-HSA-1660499 | 7.77622817275e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Synthesis of PIPs at the plasma membrane |
| KEGG:04926 | 8.44552612263e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Relaxin signaling pathway |
| KEGG:04630 | 8.66024288846e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | JAK-STAT signaling pathway |
| KEGG:04915 | 8.87856833943e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Estrogen signaling pathway |
| WP:WP4658 | 8.9153568796e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Small cell lung cancer |
| KEGG:04550 | 9.10053254791e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Signaling pathways regulating pluripotency of stem cells |
| KEGG:04910 | 9.55549752694e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Insulin signaling pathway |
| KEGG:04210 | 9.55549752694e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Apoptosis |
| KEGG:05418 | 9.55549752694e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Fluid shear stress and atherosclerosis |
| KEGG:04072 | 9.78855844223e-06 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Phospholipase D signaling pathway |
| KEGG:05162 | 1.02659874862e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Measles |
| KEGG:05224 | 1.07586932974e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Breast cancer |
| KEGG:04062 | 1.07586932974e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Chemokine signaling pathway |
| KEGG:05226 | 1.10108501715e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Gastric cancer |
| REAC:R-HSA-186797 | 1.11518017806e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Signaling by PDGF |
| KEGG:04140 | 1.15269222189e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Autophagy - animal |
| KEGG:04932 | 1.15269222189e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Non-alcoholic fatty liver disease (NAFLD) |
| WP:WP710 | 1.17293801192e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | DNA Damage Response (only ATM dependent) |
| KEGG:05160 | 1.23308771234e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Hepatitis C |
| REAC:R-HSA-74752 | 1.46159459799e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Signaling by Insulin receptor |
| KEGG:04150 | 1.46555920905e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | mTOR signaling pathway |
| KEGG:04218 | 1.49652172755e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Cellular senescence |
| KEGG:05164 | 1.59201956531e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Influenza A |
| WP:WP1449 | 1.71921496722e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Regulation of toll-like receptor signaling pathway |
| WP:WP4217 | 1.71921496722e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Ebola Virus Pathway on Host |
| KEGG:05161 | 1.8304604287e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Hepatitis B |
| KEGG:05206 | 1.90270931244e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | MicroRNAs in cancer |
| KEGG:05225 | 1.97683471245e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Hepatocellular carcinoma |
| WP:WP3929 | 1.99751915394e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Chemokine signaling pathway |
| WP:WP3915 | 1.99751915394e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Angiopoietin Like Protein 8 Regulatory Pathway |
| KEGG:04360 | 2.21071058913e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Axon guidance |
| KEGG:05167 | 2.21071058913e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Kaposi sarcoma-associated herpesvirus infection |
| REAC:R-HSA-6811558 | 2.35561805552e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| WP:WP51 | 2.41319770871e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Regulation of Actin Cytoskeleton |
| KEGG:04024 | 2.41914222835e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | cAMP signaling pathway |
| KEGG:04015 | 2.55027583186e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Rap1 signaling pathway |
| REAC:R-HSA-2219528 | 2.56967114485e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | PI3K/AKT Signaling in Cancer |
| WP:WP4239 | 2.58282233279e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Epithelial to mesenchymal transition in colorectal cancer |
| WP:WP4396 | 2.70021017308e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Nonalcoholic fatty liver disease |
| REAC:R-HSA-187037 | 2.79631294769e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Signaling by NTRK1 (TRKA) |
| KEGG:05169 | 3.02146485782e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Epstein-Barr virus infection |
| KEGG:04014 | 3.07154438585e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Ras signaling pathway |
| REAC:R-HSA-199418 | 3.16066628437e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Negative regulation of the PI3K/AKT network |
| WP:WP4666 | 3.20531604058e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Hepatitis B infection |
| KEGG:04810 | 3.2250969458e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Regulation of actin cytoskeleton |
| KEGG:05203 | 3.27739581519e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Viral carcinogenesis |
| KEGG:05205 | 3.27739581519e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Proteoglycans in cancer |
| KEGG:04510 | 3.33025703802e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Focal adhesion |
| REAC:R-HSA-1483255 | 3.42035346017e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | PI Metabolism |
| REAC:R-HSA-2029480 | 3.69388822082e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Fcgamma receptor (FCGR) dependent phagocytosis |
| KEGG:05166 | 3.77375241277e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Human T-cell leukemia virus 1 infection |
| WP:WP481 | 3.84467881578e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Insulin Signaling |
| KEGG:05170 | 3.89046029743e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Human immunodeficiency virus 1 infection |
| WP:WP4223 | 3.92056063451e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Ras Signaling |
| KEGG:05163 | 4.06999539039e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Human cytomegalovirus infection |
| REAC:R-HSA-202424 | 5.10580236014e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Downstream TCR signaling |
| REAC:R-HSA-166520 | 5.46192807335e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Signaling by NTRKs |
| REAC:R-HSA-4420097 | 5.46192807335e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | VEGFA-VEGFR2 Pathway |
| WP:WP306 | 7.01967046941e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Focal Adhesion |
| REAC:R-HSA-194138 | 7.05188258943e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Signaling by VEGF |
| REAC:R-HSA-202733 | 7.71957896197e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Cell surface interactions at the vascular wall |
| REAC:R-HSA-1500931 | 7.95116633082e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Cell-Cell communication |
| REAC:R-HSA-202403 | 8.92382428809e-05 | 1.0 | PIK3R1 PIK3R2 PIK3CB | TCR signaling |
| WP:WP22 | 0.000115031710136 | 0.666666666667 | PIK3R1 PIK3R2 | IL-9 Signaling Pathway |
| REAC:R-HSA-2454202 | 0.000126264796487 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Fc epsilon receptor (FCERI) signaling |
| KEGG:04151 | 0.00013397544306 | 1.0 | PIK3R1 PIK3R2 PIK3CB | PI3K-Akt signaling pathway |
| KEGG:05165 | 0.000150762444884 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Human papillomavirus infection |
| WP:WP3932 | 0.000177999256178 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| GO:0005942 | 0.000183816797871 | 1.0 | PIK3R1 PIK3R2 PIK3CB | phosphatidylinositol 3-kinase complex |
| WP:WP205 | 0.000221376526859 | 0.666666666667 | PIK3R1 PIK3R2 | IL-7 Signaling Pathway |
| WP:WP4172 | 0.000251129143237 | 1.0 | PIK3R1 PIK3R2 PIK3CB | PI3K-Akt Signaling Pathway |
| KEGG:05168 | 0.0002707003734 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Herpes simplex virus 1 infection |
| REAC:R-HSA-9027276 | 0.000368098478948 | 0.666666666667 | PIK3R1 PIK3CB | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) |
| REAC:R-HSA-1483257 | 0.00045921109135 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Phospholipid metabolism |
| GO:0046854 | 0.000495506150782 | 1.0 | PIK3R1 PIK3R2 PIK3CB | phosphatidylinositol phosphorylation |
| KEGG:05200 | 0.000500689425538 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Pathways in cancer |
| WP:WP244 | 0.000505754093136 | 0.666666666667 | PIK3R1 PIK3R2 | Alpha 6 Beta 4 signaling pathway |
| WP:WP2828 | 0.000603375431376 | 0.666666666667 | PIK3R1 PIK3R2 | Bladder Cancer |
| WP:WP524 | 0.000673229988357 | 0.666666666667 | PIK3R2 PIK3CB | G13 Signaling Pathway |
| WP:WP127 | 0.000673229988357 | 0.666666666667 | PIK3R1 PIK3R2 | IL-5 Signaling Pathway |
| REAC:R-HSA-9607240 | 0.000693937096245 | 1.0 | PIK3R1 PIK3R2 PIK3CB | FLT3 Signaling |
| WP:WP2332 | 0.000709588979832 | 0.666666666667 | PIK3R1 PIK3R2 | Interleukin-11 Signaling Pathway |
| REAC:R-HSA-76002 | 0.000819826928908 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Platelet activation, signaling and aggregation |
| WP:WP286 | 0.000824391260345 | 0.666666666667 | PIK3R1 PIK3R2 | IL-3 Signaling Pathway |
| WP:WP364 | 0.000824391260345 | 0.666666666667 | PIK3R1 PIK3R2 | IL-6 signaling pathway |
| REAC:R-HSA-1257604 | 0.000842184933696 | 1.0 | PIK3R1 PIK3R2 PIK3CB | PIP3 activates AKT signaling |
| REAC:R-HSA-449836 | 0.000864945777315 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Other interleukin signaling |
| GO:0046834 | 0.00104259725275 | 1.0 | PIK3R1 PIK3R2 PIK3CB | lipid phosphorylation |
| REAC:R-HSA-389357 | 0.00114404160216 | 0.666666666667 | PIK3R1 PIK3R2 | CD28 dependent PI3K/Akt signaling |
| WP:WP195 | 0.00122029571265 | 0.666666666667 | PIK3R1 PIK3R2 | IL-1 signaling pathway |
| WP:WP395 | 0.00126905060241 | 0.666666666667 | PIK3R1 PIK3R2 | IL-4 Signaling Pathway |
| WP:WP2018 | 0.00126905060241 | 0.666666666667 | PIK3R1 PIK3R2 | RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| REAC:R-HSA-9006925 | 0.00134762672661 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Intracellular signaling by second messengers |
| WP:WP585 | 0.00136941813981 | 0.666666666667 | PIK3R1 PIK3R2 | Interferon type I signaling pathways |
| WP:WP304 | 0.00147359516221 | 0.666666666667 | PIK3R1 PIK3R2 | Kit receptor signaling pathway |
| WP:WP61 | 0.00147359516221 | 0.666666666667 | PIK3R1 PIK3R2 | Notch Signaling Pathway |
| REAC:R-HSA-9006335 | 0.00169234301901 | 0.666666666667 | PIK3R1 PIK3CB | Signaling by Erythropoietin |
| WP:WP2032 | 0.00198950650794 | 0.666666666667 | PIK3R1 PIK3R2 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| REAC:R-HSA-389356 | 0.00252791438215 | 0.666666666667 | PIK3R1 PIK3R2 | CD28 co-stimulation |
| WP:WP2034 | 0.00258244514586 | 0.666666666667 | PIK3R1 PIK3R2 | Leptin signaling pathway |
| WP:WP69 | 0.00279719230313 | 0.666666666667 | PIK3R1 PIK3R2 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| REAC:R-HSA-5663202 | 0.00284240562301 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Diseases of signal transduction |
| REAC:R-HSA-1266695 | 0.00353026371942 | 0.666666666667 | PIK3R1 PIK3R2 | Interleukin-7 signaling |
| WP:WP23 | 0.00365767654025 | 0.666666666667 | PIK3R1 PIK3R2 | B Cell Receptor Signaling Pathway |
| WP:WP138 | 0.00365767654025 | 0.666666666667 | PIK3R1 PIK3R2 | Androgen receptor signaling pathway |
| REAC:R-HSA-1433557 | 0.00397787610966 | 0.666666666667 | PIK3R1 PIK3R2 | Signaling by SCF-KIT |
| REAC:R-HSA-9006934 | 0.00501472976187 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Signaling by Receptor Tyrosine Kinases |
| GO:0038096 | 0.00613252434596 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Fc-gamma receptor signaling pathway involved in phagocytosis |
| GO:0038094 | 0.00613252434596 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Fc-gamma receptor signaling pathway |
| GO:0002433 | 0.00613252434596 | 1.0 | PIK3R1 PIK3R2 PIK3CB | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis |
| GO:0048010 | 0.00613252434596 | 1.0 | PIK3R1 PIK3R2 PIK3CB | vascular endothelial growth factor receptor signaling pathway |
| GO:0002431 | 0.00664337883609 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Fc receptor mediated stimulatory signaling pathway |
| WP:WP366 | 0.00727489926623 | 0.666666666667 | PIK3R1 PIK3R2 | TGF-beta Signaling Pathway |
| WP:WP2380 | 0.00875262287344 | 0.666666666667 | PIK3R1 PIK3R2 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| WP:WP4262 | 0.00914325314966 | 0.666666666667 | PIK3R1 PIK3R2 | Breast cancer pathway |
| REAC:R-HSA-388841 | 0.00955880978777 | 0.666666666667 | PIK3R1 PIK3R2 | Costimulation by the CD28 family |
| REAC:R-HSA-449147 | 0.00988151966016 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Signaling by Interleukins |
| REAC:R-HSA-422475 | 0.0100572742862 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Axon guidance |
| REAC:R-HSA-109582 | 0.0114744505078 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Hemostasis |
| WP:WP437 | 0.0121147085229 | 0.666666666667 | PIK3R1 PIK3R2 | EGF/EGFR Signaling Pathway |
| MIRNA:hsa-miR-126-3p | 0.0138764847068 | 0.666666666667 | PIK3R1 PIK3R2 | hsa-miR-126-3p |
| REAC:R-HSA-9009391 | 0.0143204798819 | 0.666666666667 | PIK3R1 PIK3R2 | Extra-nuclear estrogen signaling |
| GO:0038095 | 0.0155935495032 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Fc-epsilon receptor signaling pathway |
| GO:0006661 | 0.0155935495032 | 1.0 | PIK3R1 PIK3R2 PIK3CB | phosphatidylinositol biosynthetic process |
| GO:0014065 | 0.0165384259681 | 1.0 | PIK3R1 PIK3R2 PIK3CB | phosphatidylinositol 3-kinase signaling |
| REAC:R-HSA-556833 | 0.0194595609558 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Metabolism of lipids |
| GO:0051897 | 0.0196004650773 | 1.0 | PIK3R1 PIK3R2 PIK3CB | positive regulation of protein kinase B signaling |
| REAC:R-HSA-1280218 | 0.0202947578047 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Adaptive Immune System |
| WP:WP3888 | 0.0226746026379 | 0.666666666667 | PIK3R1 PIK3R2 | VEGFA-VEGFR2 Signaling Pathway |
| REAC:R-HSA-1280215 | 0.0245091821355 | 1.0 | PIK3R1 PIK3R2 PIK3CB | Cytokine Signaling in Immune system |
| GO:0048015 | 0.033252767518 | 1.0 | PIK3R1 PIK3R2 PIK3CB | phosphatidylinositol-mediated signaling |
| GO:0048017 | 0.0340260876928 | 1.0 | PIK3R1 PIK3R2 PIK3CB | inositol lipid-mediated signaling |
| GO:0046488 | 0.0406485782564 | 1.0 | PIK3R1 PIK3R2 PIK3CB | phosphatidylinositol metabolic process |
| WP:WP2249 | 0.0428416541517 | 0.333333333333 | PIK3R1 | Metastatic brain tumor |
| GO:0051896 | 0.047104416733 | 1.0 | PIK3R1 PIK3R2 PIK3CB | regulation of protein kinase B signaling |
| CORUM:3133 | 0.0499776345577 | 0.333333333333 | PIK3R1 | Phosphatidylinositol 3-kinase (PIK3CA, PIK3R1) |
| CORUM:7361 | 0.0499776345577 | 0.333333333333 | PIK3R1 | ARAF-PIK3R1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PIK3R2 | PIK3R1 | 1.0 | 0.949 | bioplex (PIK3R2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| PIK3R1 | PIK3CB | 0.981 | 0.896 | hein_WMM bioplex_WMM hein (PIK3R1) fraction |
| PIK3R2 | PIK3CB | 0.127 | 0.398 | bioplex (PIK3R2) bioplex_WMM |
Images
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Complex HuMAP2_05290 has an average edge precision of 0.748 which is ranked 1175 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PIK3R1 | HuMAP2_00730 HuMAP2_02534 HuMAP2_02611 HuMAP2_05290 |
| PIK3CB | HuMAP2_00730 HuMAP2_02534 HuMAP2_05290 |
| PIK3R2 | HuMAP2_00324 HuMAP2_00730 HuMAP2_02534 HuMAP2_02611 HuMAP2_05290 HuMAP2_06494 |