hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05291
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RRM2B | Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2) | UniProt NCBI |
| RRM2 | Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4584 | 3.91210398304e-05 | 1.0 | RRM2B RRM2 | Biomarkers for pyrimidine metabolism disorders |
| WP:WP4225 | 5.06710611136e-05 | 1.0 | RRM2B RRM2 | Pyrimidine metabolism and related diseases |
| WP:WP404 | 6.37114077238e-05 | 1.0 | RRM2B RRM2 | Nucleotide Metabolism |
| KEGG:00480 | 0.000171575511903 | 1.0 | RRM2B RRM2 | Glutathione metabolism |
| KEGG:00240 | 0.000178724491566 | 1.0 | RRM2B RRM2 | Pyrimidine metabolism |
| KEGG:04115 | 0.000294129448977 | 1.0 | RRM2B RRM2 | p53 signaling pathway |
| KEGG:00983 | 0.00037291412281 | 1.0 | RRM2B RRM2 | Drug metabolism - other enzymes |
| REAC:R-HSA-499943 | 0.000588249135293 | 1.0 | RRM2B RRM2 | Interconversion of nucleotide di- and triphosphates |
| KEGG:00230 | 0.000890704506947 | 1.0 | RRM2B RRM2 | Purine metabolism |
| WP:WP4022 | 0.00114792308302 | 1.0 | RRM2B RRM2 | Pyrimidine metabolism |
| GO:0004748 | 0.00135247023414 | 1.0 | RRM2B RRM2 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| GO:0016728 | 0.00135247023414 | 1.0 | RRM2B RRM2 | oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor |
| GO:0061731 | 0.00135247023414 | 1.0 | RRM2B RRM2 | ribonucleoside-diphosphate reductase activity |
| REAC:R-HSA-15869 | 0.00612550025498 | 1.0 | RRM2B RRM2 | Metabolism of nucleotides |
| GO:0016725 | 0.0162296428096 | 1.0 | RRM2B RRM2 | oxidoreductase activity, acting on CH or CH2 groups |
| GO:0009263 | 0.0162296428096 | 1.0 | RRM2B RRM2 | deoxyribonucleotide biosynthetic process |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RRM2B | RRM2 | 0.99 | 0.909 | bioplex (RRM2,RRM2B) bioplex_WMM |
Images
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Complex HuMAP2_05291 has an average edge precision of 0.909 which is ranked 509 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RRM2B | HuMAP2_01536 HuMAP2_02802 HuMAP2_03254 HuMAP2_04276 HuMAP2_04714 HuMAP2_05291 |
| RRM2 | HuMAP2_01536 HuMAP2_04276 HuMAP2_04714 HuMAP2_05291 |