hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05297
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RPS6KA3 | Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) | UniProt NCBI |
| RPS6KA1 | Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) | UniProt NCBI |
| RPS6KA2 | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | UniProt NCBI |
| MISP | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | UniProt NCBI |
| EPB41L1 | Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N) | UniProt NCBI |
| OBSL1 | Obscurin-like protein 1 | UniProt NCBI |
| RABEPK | Rab9 effector protein with kelch motifs (40 kDa Rab9 effector protein) (p40) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-444257 | 3.71783022122e-07 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | RSK activation |
| REAC:R-HSA-199920 | 3.71783022122e-07 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | CREB phosphorylation |
| REAC:R-HSA-881907 | 5.93774784282e-06 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Gastrin-CREB signalling pathway via PKC and MAPK |
| REAC:R-HSA-198753 | 1.63090661911e-05 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | ERK/MAPK targets |
| REAC:R-HSA-198725 | 2.43429657674e-05 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Nuclear Events (kinase and transcription factor activation) |
| REAC:R-HSA-442742 | 2.75125863862e-05 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling |
| REAC:R-HSA-450282 | 4.75170870117e-05 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | MAPK targets/ Nuclear events mediated by MAP kinases |
| REAC:R-HSA-112314 | 0.00010486652338 | 0.571428571429 | EPB41L1 RPS6KA3 RPS6KA1 RPS6KA2 | Neurotransmitter receptors and postsynaptic signal transmission |
| GO:0004711 | 0.000111163123615 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | ribosomal protein S6 kinase activity |
| KEGG:04720 | 0.000124522301094 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Long-term potentiation |
| REAC:R-HSA-437239 | 0.000149580766655 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Recycling pathway of L1 |
| KEGG:04914 | 0.000279839702828 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Progesterone-mediated oocyte maturation |
| REAC:R-HSA-112315 | 0.000296731739946 | 0.571428571429 | EPB41L1 RPS6KA3 RPS6KA1 RPS6KA2 | Transmission across Chemical Synapses |
| WP:WP477 | 0.000352401426229 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Cytoplasmic Ribosomal Proteins |
| REAC:R-HSA-450294 | 0.000417086286916 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | MAP kinase activation |
| WP:WP4321 | 0.000536192356885 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Thermogenesis |
| REAC:R-HSA-448424 | 0.000549629834099 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Interleukin-17 signaling |
| KEGG:04931 | 0.000560769877896 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Insulin resistance |
| KEGG:04114 | 0.000647593933291 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Oocyte meiosis |
| KEGG:04722 | 0.000647593933291 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Neurotrophin signaling pathway |
| REAC:R-HSA-187037 | 0.000651928894468 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Signaling by NTRK1 (TRKA) |
| REAC:R-HSA-438064 | 0.000651928894468 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Post NMDA receptor activation events |
| KEGG:05135 | 0.000742879075032 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Yersinia infection |
| REAC:R-HSA-168176 | 0.000926585499379 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-168142 | 0.000926585499379 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-975871 | 0.000926585499379 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-442755 | 0.00099653441927 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Activation of NMDA receptors and postsynaptic events |
| REAC:R-HSA-975138 | 0.00099653441927 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| WP:WP3915 | 0.001023379442 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Angiopoietin Like Protein 8 Regulatory Pathway |
| REAC:R-HSA-975155 | 0.00103278420433 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-168181 | 0.00103278420433 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-168138 | 0.00118651715165 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-166058 | 0.00118651715165 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-168188 | 0.00118651715165 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-168164 | 0.00122718339452 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-166520 | 0.00126876263254 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Signaling by NTRKs |
| REAC:R-HSA-181438 | 0.00131126474762 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-168179 | 0.00131126474762 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-166166 | 0.00135469961342 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-937061 | 0.00135469961342 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-112316 | 0.00149643184588 | 0.571428571429 | EPB41L1 RPS6KA3 RPS6KA1 RPS6KA2 | Neuronal System |
| KEGG:04150 | 0.00157818210572 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | mTOR signaling pathway |
| WP:WP481 | 0.00195779096465 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Insulin Signaling |
| REAC:R-HSA-2559582 | 0.00200871067276 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Senescence-Associated Secretory Phenotype (SASP) |
| WP:WP437 | 0.00219460565949 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | EGF/EGFR Signaling Pathway |
| REAC:R-HSA-373760 | 0.00230723415657 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | L1CAM interactions |
| REAC:R-HSA-166016 | 0.00277242686137 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-416476 | 0.00396928319241 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | G alpha (q) signalling events |
| REAC:R-HSA-168898 | 0.00462829809614 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Toll-like Receptor Cascades |
| KEGG:04714 | 0.00479316829403 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Thermogenesis |
| KEGG:04010 | 0.00874793943678 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | MAPK signaling pathway |
| WP:WP4566 | 0.0103218724353 | 0.285714285714 | RPS6KA2 RPS6KA1 | Translation inhibitors in chronically activated PDGFRA cells |
| REAC:R-HSA-2559583 | 0.0111605185078 | 0.428571428571 | RPS6KA2 RPS6KA1 RPS6KA3 | Cellular Senescence |
| WP:WP304 | 0.0153237691065 | 0.285714285714 | RPS6KA1 RPS6KA3 | Kit receptor signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MISP | RPS6KA3 | 0.137 | 0.407 | bioplex (MISP) bioplex_WMM |
| MISP | RPS6KA1 | 0.135 | 0.406 | bioplex (MISP) bioplex_WMM |
| MISP | RPS6KA2 | 0.085 | 0.35 | bioplex (MISP) bioplex_WMM |
| MISP | OBSL1 | 0.083 | 0.349 | bioplex (MISP) bioplex_WMM |
| MISP | EPB41L1 | 0.03 | 0.236 | hein_WMM bioplex (MISP) bioplex_WMM |
| MISP | RABEPK | 0.025 | 0.211 | bioplex (MISP) bioplex_WMM |
| RPS6KA2 | RPS6KA3 | 0.017 | 0.176 | bioplex_WMM WMM_only |
| RPS6KA1 | RPS6KA2 | 0.014 | 0.14 | bioplex_WMM WMM_only |
| RPS6KA1 | RPS6KA3 | 0.012 | 0.148 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| RPS6KA1 | EPB41L1 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| RPS6KA2 | EPB41L1 | 0.007 | 0.007 | bioplex_WMM gupta_WMM WMM_only |
| RPS6KA3 | EPB41L1 | 0.007 | 0.008 | bioplex_WMM WMM_only |
| OBSL1 | RPS6KA1 | 0.007 | 0.003 | bioplex_WMM youn_WMM WMM_only |
| RPS6KA1 | RABEPK | 0.007 | 0.005 | bioplex_WMM WMM_only |
| OBSL1 | EPB41L1 | 0.007 | 0.003 | bioplex_WMM gupta_WMM WMM_only |
| RABEPK | EPB41L1 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| RPS6KA3 | RABEPK | 0.007 | 0.004 | bioplex_WMM WMM_only |
| RPS6KA2 | RABEPK | 0.007 | 0.006 | bioplex_WMM WMM_only |
| OBSL1 | RPS6KA3 | 0.007 | 0.008 | bioplex_WMM youn_WMM WMM_only |
| OBSL1 | RPS6KA2 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| OBSL1 | RABEPK | 0.006 | 0.004 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05297 has an average edge precision of 0.118 which is ranked 6882 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RPS6KA3 | HuMAP2_00566 HuMAP2_05297 HuMAP2_05462 HuMAP2_06014 HuMAP2_06605 |
| RPS6KA1 | HuMAP2_00566 HuMAP2_00821 HuMAP2_02828 HuMAP2_05297 HuMAP2_05462 |
| RPS6KA2 | HuMAP2_00566 HuMAP2_02828 HuMAP2_05297 HuMAP2_05462 |
| MISP | HuMAP2_00566 HuMAP2_02160 HuMAP2_05297 HuMAP2_05462 HuMAP2_05657 HuMAP2_06706 |
| EPB41L1 | HuMAP2_02844 HuMAP2_05297 HuMAP2_06471 |
| OBSL1 | HuMAP2_00566 HuMAP2_01116 HuMAP2_05297 HuMAP2_05462 |
| RABEPK | HuMAP2_00566 HuMAP2_01247 HuMAP2_05297 |