hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_05300
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AHCY | Adenosylhomocysteinase (AdoHcyase) (EC 3.3.1.1) (S-adenosyl-L-homocysteine hydrolase) | UniProt NCBI |
| RPE | Ribulose-phosphate 3-epimerase (EC 5.1.3.1) (Ribulose-5-phosphate-3-epimerase) | UniProt NCBI |
| LDHAL6A | L-lactate dehydrogenase A-like 6A (EC 1.1.1.27) | UniProt NCBI |
| ENO2 | Gamma-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 2) (Neural enolase) (Neuron-specific enolase) (NSE) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:01100 | 0.00203701694021 | 1.0 | ENO2 RPE LDHAL6A AHCY | Metabolic pathways |
| KEGG:00270 | 0.00206562690353 | 0.5 | AHCY LDHAL6A | Cysteine and methionine metabolism |
| KEGG:00010 | 0.00389180767222 | 0.5 | ENO2 LDHAL6A | Glycolysis / Gluconeogenesis |
| KEGG:01230 | 0.00494838688052 | 0.5 | ENO2 RPE | Biosynthesis of amino acids |
| KEGG:04066 | 0.00983130325145 | 0.5 | ENO2 LDHAL6A | HIF-1 signaling pathway |
| KEGG:01200 | 0.012776519361 | 0.5 | ENO2 RPE | Carbon metabolism |
| REAC:R-HSA-1430728 | 0.0467536218007 | 1.0 | ENO2 RPE LDHAL6A AHCY | Metabolism |
| REAC:R-HSA-5578997 | 0.0499190562503 | 0.25 | AHCY | Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RPE | ENO2 | 0.791 | 0.758 | fraction |
| AHCY | ENO2 | 0.681 | 0.708 | bioplex (ENO2) bioplex_WMM Guru gupta_WMM fraction treiber_WMM |
| LDHAL6A | ENO2 | 0.638 | 0.685 | fraction |
| AHCY | RPE | 0.553 | 0.646 | bioplex (RPE) fraction |
| AHCY | LDHAL6A | 0.013 | 0.155 | fraction |
Images
Click to enlarge
Complex HuMAP2_05300 has an average edge precision of 0.59 which is ranked 1988 out of all 6965 complexes.
Related Complexes