hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05304
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BIRC5 | Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin) | UniProt NCBI |
| CDCA8 | Borealin (Cell division cycle-associated protein 8) (Dasra-B) (hDasra-B) (Pluripotent embryonic stem cell-related gene 3 protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2582 | 5.02777038712e-06 | 1.0 | CDCA8 BIRC5 | Chromosomal passenger complex CPC (CDCA8, AURKB, BIRC5) |
| CORUM:1120 | 5.02777038712e-06 | 1.0 | CDCA8 BIRC5 | Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5) |
| CORUM:1119 | 1.00555407742e-05 | 1.0 | CDCA8 BIRC5 | Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB) |
| CORUM:1118 | 1.00555407742e-05 | 1.0 | CDCA8 BIRC5 | Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB) |
| REAC:R-HSA-4615885 | 0.0014429701011 | 1.0 | CDCA8 BIRC5 | SUMOylation of DNA replication proteins |
| GO:0032133 | 0.00450823411379 | 1.0 | CDCA8 BIRC5 | chromosome passenger complex |
| REAC:R-HSA-141424 | 0.0070154156135 | 1.0 | CDCA8 BIRC5 | Amplification of signal from the kinetochores |
| REAC:R-HSA-141444 | 0.0070154156135 | 1.0 | CDCA8 BIRC5 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-69618 | 0.00950416195513 | 1.0 | CDCA8 BIRC5 | Mitotic Spindle Checkpoint |
| REAC:R-HSA-2500257 | 0.0119660935214 | 1.0 | CDCA8 BIRC5 | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-5663220 | 0.0147112561527 | 1.0 | CDCA8 BIRC5 | RHO GTPases Activate Formins |
| REAC:R-HSA-3108232 | 0.0229517718172 | 1.0 | CDCA8 BIRC5 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-2990846 | 0.0246461304377 | 1.0 | CDCA8 BIRC5 | SUMOylation |
| CORUM:2580 | 0.0249595281251 | 0.5 | BIRC5 | Survivin homodimer complex |
| REAC:R-HSA-2467813 | 0.0279091534189 | 1.0 | CDCA8 BIRC5 | Separation of Sister Chromatids |
| REAC:R-HSA-68882 | 0.0304096312248 | 1.0 | CDCA8 BIRC5 | Mitotic Anaphase |
| REAC:R-HSA-68877 | 0.0304096312248 | 1.0 | CDCA8 BIRC5 | Mitotic Prometaphase |
| REAC:R-HSA-2555396 | 0.0307297326061 | 1.0 | CDCA8 BIRC5 | Mitotic Metaphase and Anaphase |
| CORUM:1117 | 0.0499173803268 | 0.5 | BIRC5 | CRM1-Survivin mitotic complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| BIRC5 | CDCA8 | 0.988 | 0.901 | bioplex (BIRC5,CDCA8) bioplex_WMM |
Images
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Complex HuMAP2_05304 has an average edge precision of 0.901 which is ranked 546 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| BIRC5 | HuMAP2_01297 HuMAP2_01678 HuMAP2_05304 |
| CDCA8 | HuMAP2_01297 HuMAP2_01678 HuMAP2_05304 |