hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05308
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MCOLN1 | Mucolipin-1 (ML1) (MG-2) (Mucolipidin) (Transient receptor potential channel mucolipin 1) (TRPML1) | UniProt NCBI |
| TMEM59L | Transmembrane protein 59-like (Brain-specific membrane-anchored protein) | UniProt NCBI |
| MCOLN3 | Mucolipin-3 (Transient receptor potential channel mucolipin 3) (TRPML3) | UniProt NCBI |
| RNF130 | E3 ubiquitin-protein ligase RNF130 (EC 2.3.2.27) (Goliath homolog) (H-Goliath) (RING finger protein 130) (RING-type E3 ubiquitin transferase RNF130) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3295583 | 0.00253927088831 | 0.5 | MCOLN1 MCOLN3 | TRP channels |
| GO:0072345 | 0.0270421395626 | 0.5 | MCOLN1 MCOLN3 | NAADP-sensitive calcium-release channel activity |
| REAC:R-HSA-2672351 | 0.0408500448467 | 0.5 | MCOLN1 MCOLN3 | Stimuli-sensing channels |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MCOLN1 | MCOLN3 | 0.068 | 0.35 | bioplex (MCOLN3) bioplex_WMM |
| MCOLN3 | RNF130 | 0.061 | 0.337 | bioplex (MCOLN3) bioplex_WMM |
| TMEM59L | MCOLN3 | 0.056 | 0.316 | bioplex (MCOLN3) bioplex_WMM |
| MCOLN1 | TMEM59L | 0.008 | 0.045 | bioplex_WMM WMM_only |
| TMEM59L | RNF130 | 0.008 | 0.01 | bioplex_WMM WMM_only |
| MCOLN1 | RNF130 | 0.007 | 0.009 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05308 has an average edge precision of 0.178 which is ranked 6449 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MCOLN1 | HuMAP2_05308 HuMAP2_05549 HuMAP2_06372 |
| TMEM59L | HuMAP2_05308 |
| MCOLN3 | HuMAP2_05308 |
| RNF130 | HuMAP2_05308 |