hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05310
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BAK1 | Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (Bcl-2-like protein 7) (Bcl2-L-7) | UniProt NCBI |
| MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5823 | 1.67592346237e-06 | 1.0 | BAK1 MCL1 | MCL1-BAK1 complex |
| WP:WP3872 | 7.07904530264e-05 | 1.0 | BAK1 MCL1 | Regulation of Apoptosis by Parathyroid Hormone-related Protein |
| WP:WP3614 | 0.000196722943147 | 1.0 | BAK1 MCL1 | Photodynamic therapy-induced HIF-1 survival signaling |
| WP:WP3611 | 0.000402760419587 | 1.0 | BAK1 MCL1 | Photodynamic therapy-induced AP-1 survival signaling. |
| WP:WP254 | 0.000979143739755 | 1.0 | BAK1 MCL1 | Apoptosis |
| KEGG:04210 | 0.00113070596705 | 1.0 | BAK1 MCL1 | Apoptosis |
| WP:WP1772 | 0.00120716351477 | 1.0 | BAK1 MCL1 | Apoptosis Modulation and Signaling |
| KEGG:05206 | 0.00178666132548 | 1.0 | BAK1 MCL1 | MicroRNAs in cancer |
| GO:0097136 | 0.00676235117068 | 1.0 | BAK1 MCL1 | Bcl-2 family protein complex |
| WP:WP4399 | 0.0221931796051 | 0.5 | MCL1 | MicroRNA network associated with chronic lymphocytic leukemia |
| MIRNA:hsa-miR-3679-3p | 0.022772013882 | 1.0 | BAK1 MCL1 | hsa-miR-3679-3p |
| MIRNA:hsa-miR-1469 | 0.0404464642509 | 0.5 | MCL1 | hsa-miR-1469 |
| REAC:R-HSA-111452 | 0.0499173803268 | 0.5 | BAK1 | Activation and oligomerization of BAK protein |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| BAK1 | MCL1 | 0.998 | 0.939 | bioplex (MCL1) |
Images
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Complex HuMAP2_05310 has an average edge precision of 0.939 which is ranked 397 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| BAK1 | HuMAP2_00283 HuMAP2_00612 HuMAP2_03955 HuMAP2_04371 HuMAP2_05310 |
| MCL1 | HuMAP2_00283 HuMAP2_00612 HuMAP2_03955 HuMAP2_04371 HuMAP2_05310 HuMAP2_05402 HuMAP2_06133 |