hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05311
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TRIB1 | Tribbles homolog 1 (TRB-1) (G-protein-coupled receptor-induced gene 2 protein) (GIG-2) (SKIP1) | UniProt NCBI |
| COP1 | E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2) | UniProt NCBI |
| STK40 | Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase) (Sugen kinase 495) (SgK495) | UniProt NCBI |
| MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase) | UniProt NCBI |
| TRIB2 | Tribbles homolog 2 (TRB-2) | UniProt NCBI |
| ETV5 | ETS translocation variant 5 (Ets-related protein ERM) | UniProt NCBI |
| ETV1 | ETS translocation variant 1 (Ets-related protein 81) | UniProt NCBI |
| DET1 | DET1 homolog (De-etiolated-1 homolog) | UniProt NCBI |
| ETS2 | Protein C-ets-2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1214 | 0.000134003222308 | 0.222222222222 | COP1 DET1 | Ubiquitin E3 ligase (DET1, DDB1, CUL4A, RBX1, COP1) |
| GO:0032436 | 0.00217873139676 | 0.444444444444 | COP1 TRIB2 DET1 TRIB1 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| GO:2000060 | 0.00386798694782 | 0.444444444444 | COP1 TRIB2 DET1 TRIB1 | positive regulation of ubiquitin-dependent protein catabolic process |
| GO:1901800 | 0.00500918315692 | 0.444444444444 | COP1 TRIB2 DET1 TRIB1 | positive regulation of proteasomal protein catabolic process |
| GO:1903052 | 0.008762328035 | 0.444444444444 | COP1 TRIB2 DET1 TRIB1 | positive regulation of proteolysis involved in cellular protein catabolic process |
| GO:0045862 | 0.00946203820533 | 0.555555555556 | TRIB1 COP1 TRIB2 DET1 MALT1 | positive regulation of proteolysis |
| GO:0032434 | 0.00996136852053 | 0.444444444444 | COP1 TRIB2 DET1 TRIB1 | regulation of proteasomal ubiquitin-dependent protein catabolic process |
| GO:1903364 | 0.0178863307425 | 0.444444444444 | COP1 TRIB2 DET1 TRIB1 | positive regulation of cellular protein catabolic process |
| GO:2000058 | 0.0236641038012 | 0.444444444444 | COP1 TRIB2 DET1 TRIB1 | regulation of ubiquitin-dependent protein catabolic process |
| CORUM:2051 | 0.0249698419797 | 0.111111111111 | MALT1 | MALT1 homo-oligomer complex |
| CORUM:2790 | 0.0249698419797 | 0.111111111111 | ETS2 | ETS2-ETS1 complex |
| CORUM:2789 | 0.0499262710315 | 0.111111111111 | ETS2 | ETS2-ERG complex |
| CORUM:2053 | 0.0499262710315 | 0.111111111111 | MALT1 | BCL10-MALT1 complex |
| CORUM:2743 | 0.0499262710315 | 0.111111111111 | MALT1 | TRAF6-MALT1 complex |
| CORUM:2744 | 0.0499262710315 | 0.111111111111 | MALT1 | TRAF2-MALT1 complex |
| CORUM:2752 | 0.0499262710315 | 0.111111111111 | MALT1 | CARMA1-BCL10-MALT1 complex |
| CORUM:2753 | 0.0499262710315 | 0.111111111111 | MALT1 | FYB-CARMA1-BCL-10-MALT1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TRIB1 | STK40 | 0.29 | 0.492 | bioplex (STK40,TRIB1) bioplex_WMM |
| COP1 | ETV5 | 0.223 | 0.467 | bioplex (ETV5) bioplex_WMM |
| DET1 | TRIB2 | 0.178 | 0.436 | bioplex (TRIB2) bioplex_WMM |
| DET1 | TRIB1 | 0.155 | 0.416 | bioplex (TRIB1) bioplex_WMM |
| TRIB2 | STK40 | 0.134 | 0.406 | bioplex (TRIB2) bioplex_WMM |
| COP1 | STK40 | 0.133 | 0.406 | bioplex (COP1,STK40) bioplex_WMM |
| DET1 | ETV5 | 0.114 | 0.384 | bioplex (ETV5) bioplex_WMM |
| COP1 | DET1 | 0.097 | 0.358 | bioplex (COP1,DET1) bioplex_WMM |
| COP1 | TRIB1 | 0.087 | 0.353 | bioplex (TRIB1) bioplex_WMM |
| COP1 | ETS2 | 0.075 | 0.356 | hein_WMM hein (ETS2) |
| MALT1 | TRIB1 | 0.069 | 0.349 | bioplex (TRIB1) bioplex_WMM |
| COP1 | TRIB2 | 0.065 | 0.347 | bioplex (TRIB2) bioplex_WMM |
| COP1 | ETV1 | 0.059 | 0.33 | bioplex (ETV1) bioplex_WMM |
| DET1 | STK40 | 0.052 | 0.301 | bioplex (DET1) bioplex_WMM |
| ETV5 | STK40 | 0.045 | 0.281 | bioplex (ETV5) bioplex_WMM |
| TRIB1 | TRIB2 | 0.016 | 0.156 | bioplex (TRIB2) bioplex_WMM |
| DET1 | MALT1 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| MALT1 | STK40 | 0.008 | 0.028 | bioplex_WMM WMM_only |
| COP1 | MALT1 | 0.008 | 0.025 | bioplex_WMM WMM_only |
| DET1 | ETV1 | 0.008 | 0.028 | bioplex (ETV1) bioplex_WMM |
| STK40 | ETV1 | 0.004 | 0.008 | bioplex (ETV1) bioplex_WMM |
Images
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Complex HuMAP2_05311 has an average edge precision of 0.285 which is ranked 4809 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TRIB1 | HuMAP2_05311 HuMAP2_05509 HuMAP2_06278 |
| COP1 | HuMAP2_04711 HuMAP2_05311 HuMAP2_05946 HuMAP2_06278 |
| STK40 | HuMAP2_05311 HuMAP2_06278 |
| MALT1 | HuMAP2_05311 HuMAP2_05509 HuMAP2_06278 |
| TRIB2 | HuMAP2_05311 HuMAP2_06278 |
| ETV5 | HuMAP2_05311 HuMAP2_06278 |
| ETV1 | HuMAP2_05311 HuMAP2_05946 HuMAP2_06278 |
| DET1 | HuMAP2_05311 HuMAP2_06278 |
| ETS2 | HuMAP2_05311 HuMAP2_05946 HuMAP2_06278 |