hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05318
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CDK9 | Cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (C-2K) (Cell division cycle 2-like protein kinase 4) (Cell division protein kinase 9) (Serine/threonine-protein kinase PITALRE) (Tat-associated kinase complex catalytic subunit) | UniProt NCBI |
| CCNT2 | Cyclin-T2 (CycT2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1080 | 1.67592346237e-06 | 1.0 | CDK9 CCNT2 | P-TEFb.2 complex |
| CORUM:6084 | 9.21757904306e-05 | 1.0 | CDK9 CCNT2 | AFF4 super elongation complex (SEC) |
| REAC:R-HSA-2173796 | 0.000779304410004 | 1.0 | CDK9 CCNT2 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| REAC:R-HSA-167287 | 0.000940193062392 | 1.0 | CDK9 CCNT2 | HIV elongation arrest and recovery |
| REAC:R-HSA-167290 | 0.000940193062392 | 1.0 | CDK9 CCNT2 | Pausing and recovery of HIV elongation |
| REAC:R-HSA-2173793 | 0.00151335888652 | 1.0 | CDK9 CCNT2 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| REAC:R-HSA-167152 | 0.00173458078356 | 1.0 | CDK9 CCNT2 | Formation of HIV elongation complex in the absence of HIV Tat |
| KEGG:05202 | 0.00178666132548 | 1.0 | CDK9 CCNT2 | Transcriptional misregulation in cancer |
| REAC:R-HSA-112382 | 0.00286750504412 | 1.0 | CDK9 CCNT2 | Formation of RNA Pol II elongation complex |
| REAC:R-HSA-75955 | 0.00286750504412 | 1.0 | CDK9 CCNT2 | RNA Polymerase II Transcription Elongation |
| REAC:R-HSA-6796648 | 0.00316917126735 | 1.0 | CDK9 CCNT2 | TP53 Regulates Transcription of DNA Repair Genes |
| HPA:047040_13 | 0.00358480028602 | 1.0 | CDK9 CCNT2 | soft tissue 1; peripheral nerve[Supported,High] |
| REAC:R-HSA-170834 | 0.00381775364729 | 1.0 | CDK9 CCNT2 | Signaling by TGF-beta Receptor Complex |
| REAC:R-HSA-167172 | 0.004164669804 | 1.0 | CDK9 CCNT2 | Transcription of the HIV genome |
| REAC:R-HSA-6807505 | 0.00452666927187 | 1.0 | CDK9 CCNT2 | RNA polymerase II transcribes snRNA genes |
| REAC:R-HSA-674695 | 0.00556574181855 | 1.0 | CDK9 CCNT2 | RNA Polymerase II Pre-transcription Events |
| HPA:047010_13 | 0.00618499553789 | 1.0 | CDK9 CCNT2 | soft tissue 1; adipocytes[Supported,High] |
| REAC:R-HSA-9006936 | 0.00656291627866 | 1.0 | CDK9 CCNT2 | Signaling by TGF-beta family members |
| GO:0097322 | 0.00676235117068 | 1.0 | CDK9 CCNT2 | 7SK snRNA binding |
| HPA:047040_03 | 0.00803689096382 | 1.0 | CDK9 CCNT2 | soft tissue 1; peripheral nerve[Uncertain,High] |
| GO:0008024 | 0.00946729163895 | 1.0 | CDK9 CCNT2 | cyclin/CDK positive transcription elongation factor complex |
| HPA:047010_03 | 0.0132004111514 | 1.0 | CDK9 CCNT2 | soft tissue 1; adipocytes[Uncertain,High] |
| REAC:R-HSA-162599 | 0.0147112561527 | 1.0 | CDK9 CCNT2 | Late Phase of HIV Life Cycle |
| HPA:047030_13 | 0.0152048156124 | 1.0 | CDK9 CCNT2 | soft tissue 1; fibroblasts[Supported,High] |
| REAC:R-HSA-162587 | 0.0177396498492 | 1.0 | CDK9 CCNT2 | HIV Life Cycle |
| HPA:022010_13 | 0.0187418520797 | 1.0 | CDK9 CCNT2 | hippocampus; glial cells[Supported,High] |
| HPA:050010_13 | 0.0214945563667 | 1.0 | CDK9 CCNT2 | spleen; cells in red pulp[Supported,High] |
| HPA:043010_13 | 0.0246385887821 | 1.0 | CDK9 CCNT2 | skin 1; Langerhans[Supported,High] |
| HPA:041010_13 | 0.0246385887821 | 1.0 | CDK9 CCNT2 | skeletal muscle; myocytes[Supported,High] |
| HPA:043020_13 | 0.0267125440668 | 1.0 | CDK9 CCNT2 | skin 1; fibroblasts[Supported,High] |
| HPA:024010_13 | 0.0277809452741 | 1.0 | CDK9 CCNT2 | kidney; cells in glomeruli[Supported,High] |
| HPA:032020_13 | 0.028650749551 | 1.0 | CDK9 CCNT2 | pancreas; islets of Langerhans[Supported,High] |
| HPA:006010_13 | 0.0295339612157 | 1.0 | CDK9 CCNT2 | caudate; glial cells[Supported,High] |
| GO:0019908 | 0.029754345151 | 1.0 | CDK9 CCNT2 | nuclear cyclin-dependent protein kinase holoenzyme complex |
| HPA:022010_03 | 0.0302051685624 | 1.0 | CDK9 CCNT2 | hippocampus; glial cells[Uncertain,High] |
| HPA:008020_13 | 0.0320319251364 | 1.0 | CDK9 CCNT2 | cerebral cortex; glial cells[Supported,High] |
| HPA:021010_13 | 0.0324969938972 | 1.0 | CDK9 CCNT2 | heart muscle; myocytes[Supported,High] |
| HPA:043040_13 | 0.0327307852202 | 1.0 | CDK9 CCNT2 | skin 1; melanocytes[Supported,High] |
| HPA:043030_13 | 0.0339123112612 | 1.0 | CDK9 CCNT2 | skin 1; keratinocytes[Supported,High] |
| HPA:027010_13 | 0.0353577952474 | 1.0 | CDK9 CCNT2 | lung; macrophages[Supported,High] |
| HPA:047030_03 | 0.036091849724 | 1.0 | CDK9 CCNT2 | soft tissue 1; fibroblasts[Uncertain,High] |
| HPA:027020_13 | 0.0363382104729 | 1.0 | CDK9 CCNT2 | lung; pneumocytes[Supported,High] |
| HPA:006020_13 | 0.0378339721631 | 1.0 | CDK9 CCNT2 | caudate; neuronal cells[Supported,High] |
| HPA:047040_12 | 0.0398752469403 | 1.0 | CDK9 CCNT2 | soft tissue 1; peripheral nerve[Supported,Medium] |
| REAC:R-HSA-162906 | 0.0414841334642 | 1.0 | CDK9 CCNT2 | HIV Infection |
| HPA:009020_13 | 0.0417053553612 | 1.0 | CDK9 CCNT2 | cervix, uterine; squamous epithelial cells[Supported,High] |
| HPA:036010_13 | 0.0417053553612 | 1.0 | CDK9 CCNT2 | prostate; glandular cells[Supported,High] |
| HPA:014020_13 | 0.042235785137 | 1.0 | CDK9 CCNT2 | endometrium 2; glandular cells[Supported,High] |
| HPA:022020_13 | 0.0430377145138 | 1.0 | CDK9 CCNT2 | hippocampus; neuronal cells[Supported,High] |
| HPA:058010_13 | 0.044664198234 | 1.0 | CDK9 CCNT2 | vagina; squamous epithelial cells[Supported,High] |
| HPA:007030_13 | 0.0454887525775 | 1.0 | CDK9 CCNT2 | cerebellum; cells in molecular layer[Supported,High] |
| GO:0001223 | 0.0473364581948 | 1.0 | CDK9 CCNT2 | transcription coactivator binding |
| HPA:040010_13 | 0.0474420413729 | 1.0 | CDK9 CCNT2 | seminal vesicle; glandular cells[Supported,High] |
| HPA:050010_03 | 0.0477244344763 | 1.0 | CDK9 CCNT2 | spleen; cells in red pulp[Uncertain,High] |
| HPA:007010_13 | 0.0480076655415 | 1.0 | CDK9 CCNT2 | cerebellum; Purkinje cells[Supported,High] |
| HPA:009010_13 | 0.0491489694193 | 1.0 | CDK9 CCNT2 | cervix, uterine; glandular cells[Supported,High] |
| HPA:006010_03 | 0.0491489694193 | 1.0 | CDK9 CCNT2 | caudate; glial cells[Uncertain,High] |
| CORUM:3229 | 0.0499173803268 | 0.5 | CDK9 | CDK9-IL6ST complex |
| CORUM:1079 | 0.0499173803268 | 0.5 | CDK9 | P-TEFb.1 complex |
| REAC:R-HSA-176034 | 0.0499173803268 | 0.5 | CDK9 | Interactions of Tat with host cellular proteins |
| CORUM:1082 | 0.0499173803268 | 0.5 | CDK9 | P-TEFb.1 complex |
| CORUM:1083 | 0.0499173803268 | 0.5 | CDK9 | P-TEFb.4 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CDK9 | CCNT2 | 1.0 | 0.949 | hein_WMM bioplex (CDK9) bioplex_WMM Guru youn_WMM Malo fraction |
Images
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Complex HuMAP2_05318 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CDK9 | HuMAP2_01724 HuMAP2_03417 HuMAP2_04784 HuMAP2_04903 HuMAP2_05318 |
| CCNT2 | HuMAP2_01724 HuMAP2_04903 HuMAP2_05318 |