hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05349
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BTK | Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) | UniProt NCBI |
| DOCK3 | Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP) | UniProt NCBI |
| ELMO2 | Engulfment and cell motility protein 2 (Protein ced-12 homolog A) (hCed-12A) | UniProt NCBI |
| DOCK4 | Dedicator of cytokinesis protein 4 | UniProt NCBI |
| ANKRD54 | Ankyrin repeat domain-containing protein 54 (Lyn-interacting ankyrin repeat protein) | UniProt NCBI |
| ELMO1 | Engulfment and cell motility protein 1 (Protein ced-12 homolog) | UniProt NCBI |
| AHI1 | Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1) | UniProt NCBI |
| DOCK1 | Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180) | UniProt NCBI |
| ELMO3 | Engulfment and cell motility protein 3 | UniProt NCBI |
| DOCK5 | Dedicator of cytokinesis protein 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:05131 | 3.06983913888e-06 | 0.4 | DOCK1 ELMO2 ELMO3 ELMO1 | Shigellosis |
| KEGG:05100 | 5.24350480147e-06 | 0.4 | DOCK1 ELMO2 ELMO3 ELMO1 | Bacterial invasion of epithelial cells |
| REAC:R-HSA-2029482 | 9.58415246346e-06 | 0.4 | DOCK1 ELMO2 BTK ELMO1 | Regulation of actin dynamics for phagocytic cup formation |
| REAC:R-HSA-8849471 | 1.29954831701e-05 | 0.3 | DOCK1 ELMO1 ELMO2 | PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases |
| CORUM:5337 | 3.01890677263e-05 | 0.2 | DOCK1 ELMO1 | ELMO1-DOCK1 complex |
| REAC:R-HSA-2029480 | 3.30799313005e-05 | 0.4 | DOCK1 ELMO2 BTK ELMO1 | Fcgamma receptor (FCGR) dependent phagocytosis |
| CORUM:5342 | 9.0534767973e-05 | 0.2 | DOCK1 ELMO1 | ELMO1-DOCK1-RAC1 complex |
| CORUM:5343 | 9.0534767973e-05 | 0.2 | DOCK1 ELMO1 | ELMO1-DOCK1-CRKII complex |
| REAC:R-HSA-983231 | 0.000522666381847 | 0.4 | DOCK1 DOCK5 DOCK4 DOCK3 | Factors involved in megakaryocyte development and platelet production |
| REAC:R-HSA-9006927 | 0.000681774092995 | 0.3 | DOCK1 ELMO1 ELMO2 | Signaling by Non-Receptor Tyrosine Kinases |
| REAC:R-HSA-8848021 | 0.000681774092995 | 0.3 | DOCK1 ELMO1 ELMO2 | Signaling by PTK6 |
| REAC:R-HSA-4420097 | 0.00537015050344 | 0.3 | DOCK1 ELMO1 ELMO2 | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-194138 | 0.00691380356188 | 0.3 | DOCK1 ELMO1 ELMO2 | Signaling by VEGF |
| GO:1904694 | 0.020287053512 | 0.2 | DOCK5 DOCK4 | negative regulation of vascular smooth muscle contraction |
| REAC:R-HSA-9006934 | 0.0211818293234 | 0.4 | DOCK1 ELMO2 ELMO1 DOCK3 | Signaling by Receptor Tyrosine Kinases |
| CORUM:6744 | 0.0499561984052 | 0.1 | AHI1 | AHI1-HAP1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ELMO1 | DOCK1 | 1.0 | 0.949 | bioplex (ELMO1) bioplex_WMM |
| DOCK3 | ELMO1 | 1.0 | 0.949 | bioplex (ELMO1) bioplex_WMM |
| DOCK4 | ELMO1 | 1.0 | 0.949 | bioplex (ELMO1) bioplex_WMM |
| ELMO1 | DOCK5 | 1.0 | 0.949 | bioplex (DOCK5,ELMO1) bioplex_WMM |
| ELMO2 | ELMO1 | 0.99 | 0.909 | bioplex (ELMO1) bioplex_WMM |
| ELMO2 | DOCK5 | 0.936 | 0.85 | hein_WMM bioplex (DOCK5) bioplex_WMM |
| DOCK1 | ELMO3 | 0.84 | 0.784 | bioplex (ELMO3) bioplex_WMM |
| DOCK3 | ELMO3 | 0.388 | 0.551 | bioplex (ELMO3) bioplex_WMM |
| DOCK5 | ELMO3 | 0.113 | 0.381 | bioplex (ELMO3) bioplex_WMM |
| ANKRD54 | DOCK5 | 0.095 | 0.359 | bioplex (DOCK5) bioplex_WMM |
| BTK | ANKRD54 | 0.061 | 0.334 | bioplex (BTK) bioplex_WMM |
| DOCK4 | ELMO3 | 0.032 | 0.244 | bioplex (ELMO3) bioplex_WMM |
| DOCK5 | AHI1 | 0.029 | 0.231 | bioplex (DOCK5) bioplex_WMM |
| ELMO2 | DOCK1 | 0.014 | 0.141 | hein_WMM bioplex_WMM WMM_only |
| DOCK4 | DOCK1 | 0.013 | 0.149 | bioplex_WMM youn_WMM WMM_only |
| DOCK4 | ELMO2 | 0.012 | 0.149 | bioplex_WMM youn_WMM WMM_only |
| DOCK1 | DOCK5 | 0.011 | 0.145 | hein_WMM bioplex_WMM WMM_only |
| DOCK3 | DOCK1 | 0.011 | 0.137 | bioplex_WMM WMM_only |
| DOCK3 | DOCK5 | 0.011 | 0.137 | bioplex_WMM WMM_only |
| ELMO2 | ELMO3 | 0.011 | 0.142 | bioplex (ELMO3) bioplex_WMM |
| DOCK4 | DOCK3 | 0.011 | 0.146 | bioplex_WMM WMM_only |
| DOCK3 | ELMO2 | 0.011 | 0.141 | bioplex_WMM WMM_only |
| DOCK4 | DOCK5 | 0.01 | 0.134 | bioplex_WMM WMM_only |
| ELMO1 | AHI1 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| ANKRD54 | AHI1 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| ELMO2 | AHI1 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| ANKRD54 | ELMO1 | 0.008 | 0.04 | bioplex_WMM WMM_only |
| ANKRD54 | ELMO2 | 0.008 | 0.027 | bioplex_WMM WMM_only |
| DOCK1 | AHI1 | 0.007 | 0.001 | youn_WMM WMM_only |
| DOCK4 | AHI1 | 0.007 | 0.005 | youn_WMM WMM_only |
| ELMO1 | ELMO3 | 0.006 | 0.004 | bioplex (ELMO3) bioplex_WMM |
Images
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Complex HuMAP2_05349 has an average edge precision of 0.329 which is ranked 4235 out of all 6965 complexes.
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