hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_05355
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AMER1 | APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein) | UniProt NCBI |
| APC | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | UniProt NCBI |
| AXIN1 | Axin-1 (Axis inhibition protein 1) (hAxin) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-4839748 | 1.63653275606e-07 | 1.0 | AMER1 AXIN1 APC | AMER1 mutants destabilize the destruction complex |
| REAC:R-HSA-4839744 | 1.63653275606e-07 | 1.0 | AMER1 AXIN1 APC | truncated APC mutants destabilize the destruction complex |
| REAC:R-HSA-4839735 | 1.63653275606e-07 | 1.0 | AMER1 AXIN1 APC | AXIN mutants destabilize the destruction complex, activating WNT signaling |
| REAC:R-HSA-5467340 | 1.63653275606e-07 | 1.0 | AMER1 AXIN1 APC | AXIN missense mutants destabilize the destruction complex |
| REAC:R-HSA-5467337 | 1.63653275606e-07 | 1.0 | AMER1 AXIN1 APC | APC truncation mutants have impaired AXIN binding |
| REAC:R-HSA-5467348 | 1.63653275606e-07 | 1.0 | AMER1 AXIN1 APC | Truncations of AMER1 destabilize the destruction complex |
| REAC:R-HSA-5358752 | 2.04566594508e-07 | 1.0 | AMER1 AXIN1 APC | T41 mutants of beta-catenin aren't phosphorylated |
| REAC:R-HSA-5358751 | 2.04566594508e-07 | 1.0 | AMER1 AXIN1 APC | S45 mutants of beta-catenin aren't phosphorylated |
| REAC:R-HSA-5358749 | 2.04566594508e-07 | 1.0 | AMER1 AXIN1 APC | S37 mutants of beta-catenin aren't phosphorylated |
| REAC:R-HSA-5358747 | 2.04566594508e-07 | 1.0 | AMER1 AXIN1 APC | S33 mutants of beta-catenin aren't phosphorylated |
| REAC:R-HSA-5339716 | 2.04566594508e-07 | 1.0 | AMER1 AXIN1 APC | Misspliced GSK3beta mutants stabilize beta-catenin |
| REAC:R-HSA-4839743 | 2.04566594508e-07 | 1.0 | AMER1 AXIN1 APC | phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex |
| REAC:R-HSA-196299 | 3.05725899484e-07 | 1.0 | AMER1 AXIN1 APC | Beta-catenin phosphorylation cascade |
| GO:1904885 | 9.08185760231e-07 | 1.0 | AMER1 AXIN1 APC | beta-catenin destruction complex assembly |
| REAC:R-HSA-4791275 | 1.82536345868e-06 | 1.0 | AMER1 AXIN1 APC | Signaling by WNT in cancer |
| REAC:R-HSA-4641262 | 1.82536345868e-06 | 1.0 | AMER1 AXIN1 APC | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| CORUM:3004 | 1.00675659188e-05 | 0.666666666667 | APC AXIN1 | APC-AXIN1-CTNNB1 complex |
| CORUM:6353 | 2.01342304124e-05 | 0.666666666667 | APC AXIN1 | beta-Catenin destruction complex |
| CORUM:3166 | 2.01342304124e-05 | 0.666666666667 | APC AXIN1 | AXIN1-APC-CTNNB1-GSK3B complex |
| REAC:R-HSA-195253 | 3.98163024387e-05 | 1.0 | AMER1 AXIN1 APC | Degradation of beta-catenin by the destruction complex |
| GO:1904886 | 0.000103533176666 | 1.0 | AMER1 AXIN1 APC | beta-catenin destruction complex disassembly |
| WP:WP3664 | 0.000130363431616 | 0.666666666667 | APC AXIN1 | Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds |
| HP:0006572 | 0.00024744441095 | 0.666666666667 | APC AXIN1 | Subacute progressive viral hepatitis |
| WP:WP2870 | 0.000287463336731 | 0.666666666667 | APC AXIN1 | Extracellular vesicle-mediated signaling in recipient cells |
| KEGG:05217 | 0.00068800303931 | 0.666666666667 | APC AXIN1 | Basal cell carcinoma |
| HP:0006562 | 0.000689155098282 | 0.666666666667 | APC AXIN1 | Viral hepatitis |
| KEGG:05213 | 0.00071298933464 | 0.666666666667 | APC AXIN1 | Endometrial cancer |
| REAC:R-HSA-201681 | 0.000808797867084 | 1.0 | AMER1 AXIN1 APC | TCF dependent signaling in response to WNT |
| WP:WP363 | 0.00112564433507 | 0.666666666667 | APC AXIN1 | Wnt Signaling Pathway |
| HP:0001413 | 0.00120138848745 | 0.666666666667 | APC AXIN1 | Micronodular cirrhosis |
| KEGG:05210 | 0.00148194300046 | 0.666666666667 | APC AXIN1 | Colorectal cancer |
| WP:WP4155 | 0.0018089728338 | 0.666666666667 | APC AXIN1 | Endometrial cancer |
| WP:WP3680 | 0.00186819955626 | 0.666666666667 | APC AXIN1 | Association Between Physico-Chemical Features and Toxicity Associated Pathways |
| REAC:R-HSA-195721 | 0.00221076692273 | 1.0 | AMER1 AXIN1 APC | Signaling by WNT |
| WP:WP4216 | 0.00237624614213 | 0.666666666667 | APC AXIN1 | Chromosomal and microsatellite instability in colorectal cancer |
| REAC:R-HSA-5663202 | 0.00284240562301 | 1.0 | AMER1 AXIN1 APC | Diseases of signal transduction |
| WP:WP4336 | 0.0028706736774 | 0.666666666667 | APC AXIN1 | ncRNAs involved in Wnt signaling in hepatocellular carcinoma |
| KEGG:04550 | 0.00334192614243 | 0.666666666667 | APC AXIN1 | Signaling pathways regulating pluripotency of stem cells |
| WP:WP4258 | 0.00357470816736 | 0.666666666667 | APC AXIN1 | LncRNA involvement in canonical Wnt signaling and colorectal cancer |
| KEGG:05224 | 0.00373360278335 | 0.666666666667 | APC AXIN1 | Breast cancer |
| GO:0008013 | 0.00378386515143 | 1.0 | AMER1 AXIN1 APC | beta-catenin binding |
| KEGG:05226 | 0.00379131738697 | 0.666666666667 | APC AXIN1 | Gastric cancer |
| KEGG:04934 | 0.00439265454468 | 0.666666666667 | APC AXIN1 | Cushing syndrome |
| WP:WP399 | 0.00444703604854 | 0.666666666667 | APC AXIN1 | Wnt Signaling Pathway and Pluripotency |
| KEGG:04390 | 0.00445520604942 | 0.666666666667 | APC AXIN1 | Hippo signaling pathway |
| WP:WP3931 | 0.00453947853799 | 0.666666666667 | APC AXIN1 | ESC Pluripotency Pathways |
| KEGG:04310 | 0.00477455273147 | 0.666666666667 | APC AXIN1 | Wnt signaling pathway |
| WP:WP710 | 0.00511400973198 | 0.666666666667 | APC AXIN1 | DNA Damage Response (only ATM dependent) |
| WP:WP428 | 0.005414047126 | 0.666666666667 | APC AXIN1 | Wnt Signaling |
| KEGG:05225 | 0.00558575423654 | 0.666666666667 | APC AXIN1 | Hepatocellular carcinoma |
| WP:WP4262 | 0.00914325314966 | 0.666666666667 | APC AXIN1 | Breast cancer pathway |
| HP:0001402 | 0.0103735850487 | 0.666666666667 | APC AXIN1 | Hepatocellular carcinoma |
| HP:0012115 | 0.017771321972 | 0.666666666667 | APC AXIN1 | Hepatitis |
| KEGG:05165 | 0.0214257750703 | 0.666666666667 | APC AXIN1 | Human papillomavirus infection |
| HP:0002896 | 0.029972334664 | 0.666666666667 | APC AXIN1 | Neoplasm of the liver |
| HP:0025423 | 0.0329433889933 | 0.666666666667 | AMER1 APC | Abnormal larynx morphology |
| HP:0031105 | 0.0409824890748 | 0.666666666667 | APC AXIN1 | Abnormal uterus morphology |
| GO:0090090 | 0.0424286223465 | 1.0 | AMER1 AXIN1 APC | negative regulation of canonical Wnt signaling pathway |
| KEGG:05200 | 0.0473113658041 | 0.666666666667 | APC AXIN1 | Pathways in cancer |
| REAC:R-HSA-5467333 | 0.0498572752401 | 0.333333333333 | APC | APC truncation mutants are not K63 polyubiquitinated |
| CORUM:1909 | 0.0499776345577 | 0.333333333333 | APC | APC-DLG4 complex |
| CORUM:1844 | 0.0499776345577 | 0.333333333333 | APC | APC-IQGAP1 complex |
| CORUM:2968 | 0.0499776345577 | 0.333333333333 | AXIN1 | Axin-SMAD3 complex |
| CORUM:933 | 0.0499776345577 | 0.333333333333 | APC | SCRIB-APC complex |
| CORUM:3168 | 0.0499776345577 | 0.333333333333 | AXIN1 | DAXX-AXIN complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| AMER1 | APC | 0.144 | 0.406 | hein_WMM bioplex_WMM youn_WMM hein (APC) |
| AXIN1 | AMER1 | 0.031 | 0.24 | hein_WMM hein (AXIN1) |
| AXIN1 | APC | 0.029 | 0.233 | hein_WMM hein (APC,AXIN1) gupta_WMM |
Images
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Complex HuMAP2_05355 has an average edge precision of 0.293 which is ranked 4699 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| AMER1 | HuMAP2_02274 HuMAP2_04643 HuMAP2_05355 HuMAP2_06022 |
| APC | HuMAP2_02274 HuMAP2_04643 HuMAP2_05355 HuMAP2_06022 |
| AXIN1 | HuMAP2_00965 HuMAP2_02771 HuMAP2_04332 HuMAP2_04384 HuMAP2_04643 HuMAP2_05355 HuMAP2_06022 HuMAP2_06340 |