hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05374
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PCGF2 | Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144) | UniProt NCBI |
| CBX8 | Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1) | UniProt NCBI |
| PHC1 | Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1) | UniProt NCBI |
| PHC2 | Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2) | UniProt NCBI |
| PHC3 | Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) | UniProt NCBI |
| BMI1 | Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51) | UniProt NCBI |
| SFMBT2 | Scm-like with four MBT domains protein 2 (Scm-like with 4 MBT domains protein 2) | UniProt NCBI |
| SCMH1 | Polycomb protein SCMH1 (Sex comb on midleg homolog 1) | UniProt NCBI |
| CBX7 | Chromobox protein homolog 7 | UniProt NCBI |
| CBX2 | Chromobox protein homolog 2 | UniProt NCBI |
| CBX4 | E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:115 | 3.07118755598e-23 | 0.727272727273 | CBX4 BMI1 PHC1 SCMH1 PHC2 CBX8 CBX2 PHC3 | Polycomb repressive complex 1 (PRC1, hPRC-H) |
| CORUM:116 | 9.21191186904e-23 | 0.727272727273 | CBX4 BMI1 PHC1 SCMH1 PHC2 CBX8 CBX2 PHC3 | Polycomb repressive complex 1 (PRC1, hPRC-H) |
| GO:0035102 | 1.38717870579e-22 | 0.818181818182 | CBX7 BMI1 PHC1 PCGF2 CBX4 PHC2 CBX8 CBX2 PHC3 | PRC1 complex |
| REAC:R-HSA-4655427 | 3.87944171751e-21 | 0.727272727273 | CBX4 BMI1 PHC1 PCGF2 PHC2 CBX8 CBX2 PHC3 | SUMOylation of DNA methylation proteins |
| GO:0000152 | 1.23179416111e-17 | 0.818181818182 | CBX7 BMI1 PHC1 PCGF2 CBX4 PHC2 CBX8 CBX2 PHC3 | nuclear ubiquitin ligase complex |
| GO:0031519 | 3.04206096319e-17 | 0.818181818182 | CBX7 BMI1 PHC1 PCGF2 CBX4 PHC2 CBX8 CBX2 PHC3 | PcG protein complex |
| REAC:R-HSA-3899300 | 4.61557879868e-17 | 0.727272727273 | CBX4 BMI1 PHC1 PCGF2 PHC2 CBX8 CBX2 PHC3 | SUMOylation of transcription cofactors |
| REAC:R-HSA-4570464 | 7.08126019834e-17 | 0.727272727273 | CBX4 BMI1 PHC1 PCGF2 PHC2 CBX8 CBX2 PHC3 | SUMOylation of RNA binding proteins |
| REAC:R-HSA-4551638 | 3.01570849318e-15 | 0.727272727273 | CBX4 BMI1 PHC1 PCGF2 PHC2 CBX8 CBX2 PHC3 | SUMOylation of chromatin organization proteins |
| REAC:R-HSA-3108214 | 6.3498095593e-15 | 0.727272727273 | CBX4 BMI1 PHC1 PCGF2 PHC2 CBX8 CBX2 PHC3 | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-8939243 | 1.86257900933e-14 | 0.636363636364 | CBX4 CBX8 CBX2 BMI1 PHC2 PHC1 PHC3 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
| REAC:R-HSA-8943724 | 5.8699980492e-13 | 0.636363636364 | CBX4 CBX8 CBX2 BMI1 PHC2 PHC1 PHC3 | Regulation of PTEN gene transcription |
| REAC:R-HSA-3108232 | 7.06930112884e-12 | 0.727272727273 | CBX4 BMI1 PHC1 PCGF2 PHC2 CBX8 CBX2 PHC3 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-2990846 | 9.43847279301e-12 | 0.727272727273 | CBX4 BMI1 PHC1 PCGF2 PHC2 CBX8 CBX2 PHC3 | SUMOylation |
| REAC:R-HSA-2559580 | 1.46453689437e-10 | 0.636363636364 | CBX4 CBX8 CBX2 BMI1 PHC2 PHC1 PHC3 | Oxidative Stress Induced Senescence |
| REAC:R-HSA-6807070 | 3.01740066858e-10 | 0.636363636364 | CBX4 CBX8 CBX2 BMI1 PHC2 PHC1 PHC3 | PTEN Regulation |
| GO:0000151 | 3.14803183336e-10 | 0.818181818182 | CBX7 BMI1 PHC1 PCGF2 CBX4 PHC2 CBX8 CBX2 PHC3 | ubiquitin ligase complex |
| REAC:R-HSA-2559583 | 3.16613692759e-09 | 0.636363636364 | CBX4 CBX8 CBX2 BMI1 PHC2 PHC1 PHC3 | Cellular Senescence |
| REAC:R-HSA-8878171 | 9.29716385126e-09 | 0.636363636364 | CBX4 CBX8 CBX2 BMI1 PHC2 PHC1 PHC3 | Transcriptional regulation by RUNX1 |
| REAC:R-HSA-1257604 | 1.12468747254e-08 | 0.636363636364 | CBX4 CBX8 CBX2 BMI1 PHC2 PHC1 PHC3 | PIP3 activates AKT signaling |
| CORUM:5518 | 2.02774899104e-08 | 0.272727272727 | PHC1 PHC2 BMI1 | BMI1-HPH1-HPH2 complex |
| REAC:R-HSA-9006925 | 3.3688017347e-08 | 0.636363636364 | CBX4 CBX8 CBX2 BMI1 PHC2 PHC1 PHC3 | Intracellular signaling by second messengers |
| CORUM:5513 | 8.10772781726e-08 | 0.272727272727 | PHC1 BMI1 CBX4 | RING1-Polycomb repressive complex |
| REAC:R-HSA-2262752 | 7.11877233268e-07 | 0.636363636364 | CBX4 CBX8 CBX2 BMI1 PHC2 PHC1 PHC3 | Cellular responses to stress |
| REAC:R-HSA-8953750 | 1.61912127235e-06 | 0.363636363636 | PCGF2 BMI1 PHC3 PHC1 | Transcriptional Regulation by E2F6 |
| REAC:R-HSA-8953897 | 2.50876005651e-06 | 0.636363636364 | CBX4 CBX8 CBX2 BMI1 PHC2 PHC1 PHC3 | Cellular responses to external stimuli |
| GO:1990234 | 2.65527121969e-06 | 0.818181818182 | CBX7 BMI1 PHC1 PCGF2 CBX4 PHC2 CBX8 CBX2 PHC3 | transferase complex |
| REAC:R-HSA-212436 | 1.57511751428e-05 | 0.727272727273 | CBX4 BMI1 PHC1 PCGF2 PHC2 CBX8 CBX2 PHC3 | Generic Transcription Pathway |
| REAC:R-HSA-73857 | 3.69079956709e-05 | 0.727272727273 | CBX4 BMI1 PHC1 PCGF2 PHC2 CBX8 CBX2 PHC3 | RNA Polymerase II Transcription |
| REAC:R-HSA-597592 | 7.32351107308e-05 | 0.727272727273 | CBX4 BMI1 PHC1 PCGF2 PHC2 CBX8 CBX2 PHC3 | Post-translational protein modification |
| REAC:R-HSA-74160 | 8.63729197621e-05 | 0.727272727273 | CBX4 BMI1 PHC1 PCGF2 PHC2 CBX8 CBX2 PHC3 | Gene expression (Transcription) |
| CORUM:1462 | 0.000201152732593 | 0.181818181818 | PHC2 BMI1 | hPRC1L complex |
| GO:1902494 | 0.00031759147892 | 0.818181818182 | CBX7 BMI1 PHC1 PCGF2 CBX4 PHC2 CBX8 CBX2 PHC3 | catalytic complex |
| GO:0070317 | 0.000525134045179 | 0.363636363636 | PCGF2 BMI1 PHC3 PHC1 | negative regulation of G0 to G1 transition |
| GO:0070316 | 0.000586693494072 | 0.363636363636 | PCGF2 BMI1 PHC3 PHC1 | regulation of G0 to G1 transition |
| GO:0045023 | 0.000725835392359 | 0.363636363636 | PCGF2 BMI1 PHC3 PHC1 | G0 to G1 transition |
| REAC:R-HSA-392499 | 0.00120229815954 | 0.727272727273 | CBX4 BMI1 PHC1 PCGF2 PHC2 CBX8 CBX2 PHC3 | Metabolism of proteins |
| GO:0005654 | 0.0021313263302 | 1.0 | CBX7 BMI1 SFMBT2 CBX2 PCGF2 CBX4 CBX8 PHC2 PHC1 PHC3 SCMH1 | nucleoplasm |
| GO:0031981 | 0.0170336395485 | 1.0 | CBX7 BMI1 SFMBT2 CBX2 PCGF2 CBX4 CBX8 PHC2 PHC1 PHC3 SCMH1 | nuclear lumen |
| CORUM:929 | 0.0220329934501 | 0.181818181818 | CBX8 BMI1 | CEN complex |
| GO:0045892 | 0.0294573975935 | 0.636363636364 | CBX7 CBX4 PCGF2 BMI1 CBX8 CBX2 SCMH1 | negative regulation of transcription, DNA-templated |
| GO:1903507 | 0.0299238228586 | 0.636363636364 | CBX7 CBX4 PCGF2 BMI1 CBX8 CBX2 SCMH1 | negative regulation of nucleic acid-templated transcription |
| GO:1902679 | 0.030159373501 | 0.636363636364 | CBX7 CBX4 PCGF2 BMI1 CBX8 CBX2 SCMH1 | negative regulation of RNA biosynthetic process |
| REAC:R-HSA-162582 | 0.0306388368258 | 0.636363636364 | CBX4 CBX8 CBX2 BMI1 PHC2 PHC1 PHC3 | Signal Transduction |
| GO:0044428 | 0.0345199601716 | 1.0 | CBX7 BMI1 SFMBT2 CBX2 PCGF2 CBX4 CBX8 PHC2 PHC1 PHC3 SCMH1 | nuclear part |
| GO:0010629 | 0.0411186050798 | 0.727272727273 | CBX7 SFMBT2 CBX4 PCGF2 CBX8 BMI1 CBX2 SCMH1 | negative regulation of gene expression |
| CORUM:0000000 | 0.0434839362249 | 0.727272727273 | CBX4 BMI1 PHC1 SCMH1 PHC2 CBX8 CBX2 PHC3 | CORUM root |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PHC1 | BMI1 | 0.997 | 0.93 | bioplex (PHC1) bioplex_WMM |
| CBX8 | PHC1 | 0.986 | 0.901 | hein_WMM bioplex (PHC1) bioplex_WMM youn_WMM hein (CBX8) |
| SCMH1 | PHC1 | 0.965 | 0.874 | bioplex (PHC1) bioplex_WMM |
| CBX8 | PCGF2 | 0.955 | 0.862 | bioplex (PCGF2) bioplex_WMM |
| CBX7 | PHC2 | 0.946 | 0.857 | hein_WMM bioplex (CBX7) bioplex_WMM hein (CBX7) |
| PCGF2 | SCMH1 | 0.926 | 0.844 | bioplex (PCGF2) bioplex_WMM |
| PCGF2 | PHC3 | 0.871 | 0.804 | bioplex (PCGF2) bioplex_WMM |
| CBX4 | PHC1 | 0.864 | 0.801 | hein_WMM bioplex (PHC1) bioplex_WMM hein (CBX4) |
| CBX7 | PHC3 | 0.833 | 0.78 | hein_WMM bioplex (CBX7) bioplex_WMM hein (CBX7) |
| PCGF2 | CBX2 | 0.765 | 0.749 | bioplex (PCGF2) bioplex_WMM |
| PCGF2 | PHC1 | 0.706 | 0.727 | bioplex (PCGF2,PHC1) bioplex_WMM |
| PCGF2 | PHC2 | 0.68 | 0.708 | bioplex (PCGF2) bioplex_WMM |
| PHC1 | CBX2 | 0.6 | 0.67 | hein_WMM bioplex (PHC1) bioplex_WMM youn_WMM |
| PCGF2 | CBX4 | 0.369 | 0.544 | bioplex (PCGF2) bioplex_WMM |
| PHC1 | PHC3 | 0.364 | 0.543 | hein_WMM bioplex (PHC1) bioplex_WMM youn_WMM |
| PHC1 | CBX7 | 0.34 | 0.528 | bioplex (PHC1) bioplex_WMM |
| PCGF2 | CBX7 | 0.312 | 0.505 | bioplex (PCGF2) bioplex_WMM |
| PHC1 | PHC2 | 0.21 | 0.457 | hein_WMM bioplex (PHC1) bioplex_WMM youn_WMM |
| CBX8 | PHC3 | 0.123 | 0.395 | hein_WMM bioplex_WMM youn_WMM hein (CBX8) |
| PHC1 | SFMBT2 | 0.112 | 0.381 | bioplex (PHC1) bioplex_WMM |
| CBX8 | CBX4 | 0.073 | 0.354 | hein_WMM bioplex_WMM hein (CBX4,CBX8) |
| CBX8 | PHC2 | 0.067 | 0.352 | hein_WMM bioplex_WMM youn_WMM hein (CBX8) |
| CBX4 | PHC3 | 0.062 | 0.341 | hein_WMM bioplex_WMM hein (CBX4) |
| CBX4 | PHC2 | 0.041 | 0.269 | hein_WMM bioplex_WMM hein (CBX4) |
| CBX8 | CBX7 | 0.023 | 0.209 | hein_WMM bioplex_WMM hein (CBX7) |
| PHC2 | PHC3 | 0.017 | 0.175 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| CBX2 | PHC2 | 0.01 | 0.126 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| CBX8 | CBX2 | 0.01 | 0.126 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| CBX8 | SCMH1 | 0.01 | 0.1 | bioplex_WMM WMM_only |
| CBX2 | PHC3 | 0.01 | 0.1 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| SCMH1 | CBX7 | 0.01 | 0.103 | bioplex_WMM WMM_only |
| SCMH1 | CBX2 | 0.009 | 0.109 | bioplex_WMM WMM_only |
| CBX2 | CBX7 | 0.009 | 0.109 | bioplex_WMM WMM_only |
| SCMH1 | PHC2 | 0.009 | 0.109 | bioplex_WMM WMM_only |
| SCMH1 | PHC3 | 0.009 | 0.107 | bioplex_WMM WMM_only |
| SCMH1 | CBX4 | 0.009 | 0.09 | bioplex_WMM WMM_only |
| CBX4 | CBX7 | 0.009 | 0.09 | bioplex_WMM WMM_only |
| BMI1 | SFMBT2 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| CBX4 | CBX2 | 0.009 | 0.098 | hein_WMM bioplex_WMM WMM_only |
| CBX8 | SFMBT2 | 0.008 | 0.088 | bioplex_WMM WMM_only |
| CBX8 | BMI1 | 0.008 | 0.088 | bioplex_WMM WMM_only |
| SCMH1 | SFMBT2 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| CBX7 | SFMBT2 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| SCMH1 | BMI1 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| BMI1 | CBX7 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| CBX2 | SFMBT2 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| CBX2 | BMI1 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| PHC2 | SFMBT2 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| BMI1 | PHC2 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| PCGF2 | BMI1 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| PCGF2 | SFMBT2 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| PHC3 | SFMBT2 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| BMI1 | PHC3 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| CBX4 | SFMBT2 | 0.008 | 0.066 | bioplex_WMM WMM_only |
| CBX4 | BMI1 | 0.008 | 0.066 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05374 has an average edge precision of 0.332 which is ranked 4213 out of all 6965 complexes.
Related Complexes