hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05376
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| XIAP | E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP) | UniProt NCBI |
| HTRA2 | Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI) | UniProt NCBI |
| CASP9 | Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10] | UniProt NCBI |
| BIRC8 | Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis-like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04215 | 1.22093847236e-07 | 1.0 | XIAP HTRA2 CASP9 | Apoptosis - multiple species |
| WP:WP1772 | 5.49549000446e-06 | 1.0 | XIAP HTRA2 CASP9 | Apoptosis Modulation and Signaling |
| KEGG:04210 | 9.55549752694e-06 | 1.0 | XIAP HTRA2 CASP9 | Apoptosis |
| CORUM:5317 | 1.00675659188e-05 | 0.666666666667 | XIAP HTRA2 | LATS1-HTRA2-BIRC4 complex |
| REAC:R-HSA-111459 | 0.000100412974104 | 0.666666666667 | XIAP CASP9 | Activation of caspases through apoptosome-mediated cleavage |
| WP:WP2507 | 0.000163898158608 | 0.666666666667 | HTRA2 CASP9 | Nanomaterial induced apoptosis |
| REAC:R-HSA-111469 | 0.000187420766709 | 0.666666666667 | XIAP CASP9 | SMAC, XIAP-regulated apoptotic response |
| REAC:R-HSA-111464 | 0.000187420766709 | 0.666666666667 | XIAP CASP9 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes |
| REAC:R-HSA-111463 | 0.000187420766709 | 0.666666666667 | XIAP CASP9 | SMAC (DIABLO) binds to IAPs |
| REAC:R-HSA-9627069 | 0.000441698392473 | 0.666666666667 | XIAP CASP9 | Regulation of the apoptosome activity |
| REAC:R-HSA-111458 | 0.000441698392473 | 0.666666666667 | XIAP CASP9 | Formation of apoptosome |
| WP:WP2371 | 0.000603375431376 | 0.666666666667 | HTRA2 CASP9 | Parkinsons Disease Pathway |
| REAC:R-HSA-111461 | 0.00060895383853 | 0.666666666667 | XIAP CASP9 | Cytochrome c-mediated apoptotic response |
| WP:WP1433 | 0.000673229988357 | 0.666666666667 | XIAP CASP9 | Nucleotide-binding Oligomerization Domain (NOD) pathway |
| REAC:R-HSA-111471 | 0.000802944115303 | 0.666666666667 | XIAP CASP9 | Apoptotic factor-mediated response |
| WP:WP4008 | 0.000864566693143 | 0.666666666667 | XIAP CASP9 | NO/cGMP/PKG mediated Neuroprotection |
| KEGG:01524 | 0.0011410864499 | 0.666666666667 | XIAP CASP9 | Platinum drug resistance |
| KEGG:05222 | 0.00186709616111 | 0.666666666667 | XIAP CASP9 | Small cell lung cancer |
| KEGG:05145 | 0.00194943709371 | 0.666666666667 | XIAP CASP9 | Toxoplasmosis |
| WP:WP254 | 0.00251276217802 | 0.666666666667 | XIAP CASP9 | Apoptosis |
| KEGG:05012 | 0.00350714576187 | 0.666666666667 | HTRA2 CASP9 | Parkinson disease |
| REAC:R-HSA-109606 | 0.00818423736949 | 0.666666666667 | XIAP CASP9 | Intrinsic Pathway for Apoptosis |
| KEGG:05200 | 0.0473113658041 | 0.666666666667 | XIAP CASP9 | Pathways in cancer |
| GO:0043281 | 0.0480789908723 | 1.0 | XIAP HTRA2 CASP9 | regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| CORUM:6292 | 0.0499776345577 | 0.333333333333 | XIAP | HAX-1-XIAP complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CASP9 | BIRC8 | 0.984 | 0.899 | bioplex (112401) bioplex_WMM |
| HTRA2 | BIRC8 | 0.915 | 0.839 | bioplex (112401) bioplex_WMM |
| XIAP | BIRC8 | 0.105 | 0.37 | bioplex (112401) bioplex_WMM |
| XIAP | CASP9 | 0.008 | 0.076 | bioplex_WMM WMM_only |
| HTRA2 | CASP9 | 0.008 | 0.044 | bioplex_WMM WMM_only |
| HTRA2 | XIAP | 0.007 | 0.003 | bioplex_WMM boldt youn_WMM boldt_WMM |
Images
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Complex HuMAP2_05376 has an average edge precision of 0.372 which is ranked 3621 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| XIAP | HuMAP2_00392 HuMAP2_00911 HuMAP2_01596 HuMAP2_03984 HuMAP2_05376 HuMAP2_06122 |
| HTRA2 | HuMAP2_00263 HuMAP2_05376 HuMAP2_05504 HuMAP2_06026 |
| CASP9 | HuMAP2_05018 HuMAP2_05376 HuMAP2_05504 |
| BIRC8 | HuMAP2_05018 HuMAP2_05376 HuMAP2_05504 |