hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_05384
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SUPT5H | Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) | UniProt NCBI |
| SUPT6H | Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein) | UniProt NCBI |
| SUPT4H1 | Transcription elongation factor SPT4 (hSPT4) (DRB sensitivity-inducing factor 14 kDa subunit) (DSIF p14) (DRB sensitivity-inducing factor small subunit) (DSIF small subunit) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2860 | 3.35600554376e-06 | 0.666666666667 | SUPT5H SUPT4H1 | DSIF complex (DRB sensitivity-inducing factor complex) |
| CORUM:2861 | 3.35600554376e-06 | 0.666666666667 | SUPT5H SUPT4H1 | DSIF complex (DRB sensitivity-inducing factor complex) |
| REAC:R-HSA-75955 | 1.46159459799e-05 | 1.0 | SUPT5H SUPT4H1 SUPT6H | RNA Polymerase II Transcription Elongation |
| REAC:R-HSA-112382 | 1.46159459799e-05 | 1.0 | SUPT5H SUPT4H1 SUPT6H | Formation of RNA Pol II elongation complex |
| REAC:R-HSA-674695 | 3.98163024387e-05 | 1.0 | SUPT5H SUPT4H1 SUPT6H | RNA Polymerase II Pre-transcription Events |
| GO:0032786 | 0.000331851076788 | 1.0 | SUPT5H SUPT4H1 SUPT6H | positive regulation of DNA-templated transcription, elongation |
| WP:WP3414 | 0.000416728443271 | 0.666666666667 | SUPT5H SUPT4H1 | Initiation of transcription and translation elongation at the HIV-1 LTR |
| GO:0032044 | 0.00135247023414 | 0.666666666667 | SUPT5H SUPT4H1 | DSIF complex |
| GO:0032784 | 0.00137862598403 | 1.0 | SUPT5H SUPT4H1 SUPT6H | regulation of DNA-templated transcription, elongation |
| REAC:R-HSA-167242 | 0.00169234301901 | 0.666666666667 | SUPT5H SUPT4H1 | Abortive elongation of HIV-1 transcript in the absence of Tat |
| GO:0008023 | 0.00178004409005 | 1.0 | SUPT5H SUPT4H1 SUPT6H | transcription elongation factor complex |
| REAC:R-HSA-167238 | 0.0033164570092 | 0.666666666667 | SUPT5H SUPT4H1 | Pausing and recovery of Tat-mediated HIV elongation |
| REAC:R-HSA-167243 | 0.0033164570092 | 0.666666666667 | SUPT5H SUPT4H1 | Tat-mediated HIV elongation arrest and recovery |
| REAC:R-HSA-167158 | 0.00353026371942 | 0.666666666667 | SUPT5H SUPT4H1 | Formation of the HIV-1 Early Elongation Complex |
| REAC:R-HSA-113418 | 0.00353026371942 | 0.666666666667 | SUPT5H SUPT4H1 | Formation of the Early Elongation Complex |
| REAC:R-HSA-167287 | 0.00375073705264 | 0.666666666667 | SUPT5H SUPT4H1 | HIV elongation arrest and recovery |
| REAC:R-HSA-167290 | 0.00375073705264 | 0.666666666667 | SUPT5H SUPT4H1 | Pausing and recovery of HIV elongation |
| REAC:R-HSA-167200 | 0.00632193682699 | 0.666666666667 | SUPT5H SUPT4H1 | Formation of HIV-1 elongation complex containing HIV-1 Tat |
| REAC:R-HSA-167246 | 0.00632193682699 | 0.666666666667 | SUPT5H SUPT4H1 | Tat-mediated elongation of the HIV-1 transcript |
| REAC:R-HSA-167169 | 0.00632193682699 | 0.666666666667 | SUPT5H SUPT4H1 | HIV Transcription Elongation |
| REAC:R-HSA-167152 | 0.00691608633843 | 0.666666666667 | SUPT5H SUPT4H1 | Formation of HIV elongation complex in the absence of HIV Tat |
| GO:0006368 | 0.00718184217333 | 1.0 | SUPT5H SUPT4H1 SUPT6H | transcription elongation from RNA polymerase II promoter |
| REAC:R-HSA-6796648 | 0.0126269885924 | 0.666666666667 | SUPT5H SUPT4H1 | TP53 Regulates Transcription of DNA Repair Genes |
| REAC:R-HSA-167172 | 0.0165866686159 | 0.666666666667 | SUPT5H SUPT4H1 | Transcription of the HIV genome |
| GO:0006354 | 0.0170248502613 | 1.0 | SUPT5H SUPT4H1 SUPT6H | DNA-templated transcription, elongation |
| REAC:R-HSA-6807505 | 0.0180259784934 | 0.666666666667 | SUPT5H SUPT4H1 | RNA polymerase II transcribes snRNA genes |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SUPT4H1 | SUPT5H | 0.999 | 0.945 | youn (SUPT5H) bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| SUPT6H | SUPT5H | 0.5 | 0.621 | hein_WMM youn (SUPT5H) bioplex_WMM youn_WMM fraction |
| SUPT4H1 | SUPT6H | 0.003 | 0.013 | hein_WMM bioplex_WMM youn_WMM fraction |
Images
Click to enlarge
Complex HuMAP2_05384 has an average edge precision of 0.526 which is ranked 2362 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SUPT5H | HuMAP2_04857 HuMAP2_05384 HuMAP2_05667 HuMAP2_06690 |
| SUPT6H | HuMAP2_04203 HuMAP2_05384 HuMAP2_06690 |
| SUPT4H1 | HuMAP2_00694 HuMAP2_04857 HuMAP2_05384 HuMAP2_05667 HuMAP2_06690 |