hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05404
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NCOA7 | Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) | UniProt NCBI |
| ATP6V1E2 | V-type proton ATPase subunit E 2 (V-ATPase subunit E 2) (Vacuolar proton pump subunit E 2) | UniProt NCBI |
| MAGEA2 | Melanoma-associated antigen 2 (Cancer/testis antigen 1.2) (CT1.2) (MAGE-2 antigen) | UniProt NCBI |
| ATP6V1B1 | V-type proton ATPase subunit B, kidney isoform (V-ATPase subunit B 1) (Endomembrane proton pump 58 kDa subunit) (Vacuolar proton pump subunit B 1) | UniProt NCBI |
| ATP6V1G2 | V-type proton ATPase subunit G 2 (V-ATPase subunit G 2) (V-ATPase 13 kDa subunit 2) (Vacuolar proton pump subunit G 2) | UniProt NCBI |
| ATP6V1C2 | V-type proton ATPase subunit C 2 (V-ATPase subunit C 2) (Vacuolar proton pump subunit C 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04966 | 1.4678841019e-09 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | Collecting duct acid secretion |
| REAC:R-HSA-77387 | 3.87647729286e-09 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | Insulin receptor recycling |
| REAC:R-HSA-917977 | 8.66228610405e-09 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | Transferrin endocytosis and recycling |
| REAC:R-HSA-1222556 | 1.31129440131e-08 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | ROS and RNS production in phagocytes |
| KEGG:05110 | 2.2550793672e-08 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | Vibrio cholerae infection |
| KEGG:05323 | 4.25486304909e-08 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | Rheumatoid arthritis |
| KEGG:05120 | 6.04378937267e-08 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | Epithelial cell signaling in Helicobacter pylori infection |
| KEGG:04721 | 8.87400860001e-08 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | Synaptic vesicle cycle |
| REAC:R-HSA-917937 | 1.15185554341e-07 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | Iron uptake and transport |
| REAC:R-HSA-74752 | 1.65722225947e-07 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | Signaling by Insulin receptor |
| KEGG:00190 | 8.86004201186e-07 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | Oxidative phosphorylation |
| KEGG:04145 | 1.52643011028e-06 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | Phagosome |
| KEGG:04150 | 1.98064768411e-06 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | mTOR signaling pathway |
| GO:0090383 | 2.13806517127e-06 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | phagosome acidification |
| GO:0033572 | 4.983554895e-06 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | transferrin transport |
| GO:0090382 | 7.17274954203e-06 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | phagosome maturation |
| REAC:R-HSA-983712 | 9.52229417821e-06 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | Ion channel transport |
| GO:0051452 | 1.2328136433e-05 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | intracellular pH reduction |
| GO:0045851 | 1.36251014669e-05 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | pH reduction |
| GO:0006826 | 4.1487149847e-05 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | iron ion transport |
| KEGG:05165 | 4.42454478418e-05 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | Human papillomavirus infection |
| GO:0051453 | 9.31770903001e-05 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | regulation of intracellular pH |
| GO:0030641 | 0.000105081675568 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | regulation of cellular pH |
| GO:0006885 | 0.000125031076937 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | regulation of pH |
| GO:0030004 | 0.000202099795148 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | cellular monovalent inorganic cation homeostasis |
| GO:0000041 | 0.000234344694802 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | transition metal ion transport |
| GO:0008286 | 0.00037017279064 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | insulin receptor signaling pathway |
| REAC:R-HSA-9006934 | 0.000402506828977 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | Signaling by Receptor Tyrosine Kinases |
| GO:0055067 | 0.0005799178998 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | monovalent inorganic cation homeostasis |
| GO:0016471 | 0.000616695699567 | 0.6 | ATP6V1C2 ATP6V1B1 ATP6V1G2 | vacuolar proton-transporting V-type ATPase complex |
| GO:0033176 | 0.000878614215261 | 0.6 | ATP6V1C2 ATP6V1B1 ATP6V1G2 | proton-transporting V-type ATPase complex |
| GO:0032869 | 0.00191030232031 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | cellular response to insulin stimulus |
| REAC:R-HSA-382551 | 0.00191509203292 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | Transport of small molecules |
| GO:0016241 | 0.00207968006832 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | regulation of macroautophagy |
| GO:0032868 | 0.0023227175406 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | response to insulin |
| GO:0071375 | 0.00705155239441 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | cellular response to peptide hormone stimulus |
| REAC:R-HSA-168249 | 0.0093160298358 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | Innate Immune System |
| GO:0016469 | 0.00964423896068 | 0.6 | ATP6V1C2 ATP6V1B1 ATP6V1G2 | proton-transporting two-sector ATPase complex |
| GO:0043434 | 0.0114494096842 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | response to peptide hormone |
| KEGG:01100 | 0.0121945453342 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | Metabolic pathways |
| GO:1901653 | 0.0144170627587 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | cellular response to peptide |
| GO:0016236 | 0.0210321541014 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | macroautophagy |
| GO:0010506 | 0.0234344442687 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | regulation of autophagy |
| GO:1901652 | 0.0252719643298 | 0.8 | ATP6V1C2 ATP6V1E2 ATP6V1G2 ATP6V1B1 | response to peptide |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ATP6V1C2 | ATP6V1E2 | 1.0 | 0.949 | bioplex (ATP6V1C2) bioplex_WMM |
| ATP6V1B1 | ATP6V1E2 | 1.0 | 0.949 | bioplex (ATP6V1B1) bioplex_WMM |
| ATP6V1C2 | ATP6V1G2 | 0.904 | 0.828 | bioplex (ATP6V1C2) bioplex_WMM |
| ATP6V1B1 | NCOA7 | 0.18 | 0.437 | bioplex (ATP6V1B1) bioplex_WMM youn_WMM |
| ATP6V1B1 | ATP6V1G2 | 0.084 | 0.349 | bioplex (ATP6V1B1) bioplex_WMM |
| ATP6V1C2 | MAGEA2 | 0.049 | 0.294 | hein_WMM hein (ATP6V1C2) |
| ATP6V1G2 | ATP6V1E2 | 0.012 | 0.146 | bioplex_WMM WMM_only |
| ATP6V1E2 | NCOA7 | 0.009 | 0.101 | bioplex_WMM WMM_only |
| ATP6V1G2 | NCOA7 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| ATP6V1C2 | NCOA7 | 0.008 | 0.088 | bioplex_WMM WMM_only |
| ATP6V1C2 | ATP6V1B1 | 0.004 | 0.013 | bioplex (ATP6V1B1) bioplex_WMM |
Images
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Complex HuMAP2_05404 has an average edge precision of 0.386 which is ranked 3462 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NCOA7 | HuMAP2_05404 HuMAP2_06811 HuMAP2_06925 |
| ATP6V1E2 | HuMAP2_03123 HuMAP2_05404 HuMAP2_05625 HuMAP2_06811 HuMAP2_06925 |
| MAGEA2 | HuMAP2_05404 HuMAP2_06925 |
| ATP6V1B1 | HuMAP2_00898 HuMAP2_03123 HuMAP2_05404 HuMAP2_05625 HuMAP2_06811 HuMAP2_06925 |
| ATP6V1G2 | HuMAP2_00898 HuMAP2_05404 HuMAP2_05625 HuMAP2_06811 HuMAP2_06925 |
| ATP6V1C2 | HuMAP2_00898 HuMAP2_03123 HuMAP2_05404 HuMAP2_05625 HuMAP2_06925 |