hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05414
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PHB2 | Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity) | UniProt NCBI |
| SLC25A3 | Phosphate carrier protein, mitochondrial (Phosphate transport protein) (PTP) (Solute carrier family 25 member 3) | UniProt NCBI |
| SLC25A6 | ADP/ATP translocase 3 (ADP,ATP carrier protein 3) (ADP,ATP carrier protein, isoform T2) (ANT 2) (Adenine nucleotide translocator 3) (ANT 3) (Solute carrier family 25 member 6) [Cleaved into: ADP/ATP translocase 3, N-terminally processed] | UniProt NCBI |
| UQCRC2 | Cytochrome b-c1 complex subunit 2, mitochondrial (Complex III subunit 2) (Core protein II) (Ubiquinol-cytochrome-c reductase complex core protein 2) | UniProt NCBI |
| TUFM | Elongation factor Tu, mitochondrial (EF-Tu) (P43) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0001942 | 0.00098402511782 | 0.6 | UQCRC2 SLC25A3 TUFM | Metabolic acidosis |
| HP:0002151 | 0.00488448031495 | 0.6 | UQCRC2 SLC25A3 TUFM | Increased serum lactate |
| WP:WP111 | 0.0141122881464 | 0.4 | UQCRC2 SLC25A6 | Electron Transport Chain (OXPHOS system in mitochondria) |
| GO:0044429 | 0.0210056852384 | 1.0 | TUFM PHB2 SLC25A6 SLC25A3 UQCRC2 | mitochondrial part |
| KEGG:05012 | 0.0332521613209 | 0.4 | UQCRC2 SLC25A6 | Parkinson disease |
| HP:0001941 | 0.0347361605983 | 0.6 | UQCRC2 SLC25A3 TUFM | Acidosis |
| HP:0004360 | 0.0450566918732 | 0.6 | UQCRC2 SLC25A3 TUFM | Abnormality of acid-base homeostasis |
| HP:0001987 | 0.0478196851342 | 0.4 | UQCRC2 TUFM | Hyperammonemia |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SLC25A3 | UQCRC2 | 0.967 | 0.88 | bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| UQCRC2 | SLC25A6 | 0.855 | 0.793 | bioplex (SLC25A6) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| UQCRC2 | TUFM | 0.801 | 0.766 | bioplex (TUFM) bioplex_WMM Guru boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| PHB2 | UQCRC2 | 0.777 | 0.752 | hein_WMM bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| PHB2 | SLC25A6 | 0.601 | 0.671 | bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| PHB2 | SLC25A3 | 0.579 | 0.661 | bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| SLC25A3 | SLC25A6 | 0.168 | 0.425 | bioplex (SLC25A6) bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| SLC25A3 | TUFM | 0.005 | 0.012 | bioplex (TUFM) bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| PHB2 | TUFM | 0.0 | 0.015 | bioplex (PHB2) bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| SLC25A6 | TUFM | 0.0 | 0.001 | bioplex (SLC25A6,TUFM) bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_05414 has an average edge precision of 0.498 which is ranked 2513 out of all 6965 complexes.
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