hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05418
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TOMM40 | Mitochondrial import receptor subunit TOM40 homolog (Protein Haymaker) (Translocase of outer membrane 40 kDa subunit homolog) (p38.5) | UniProt NCBI |
| TOMM22 | Mitochondrial import receptor subunit TOM22 homolog (hTom22) (1C9-2) (Translocase of outer membrane 22 kDa subunit homolog) | UniProt NCBI |
| TOMM40L | Mitochondrial import receptor subunit TOM40B (Protein TOMM40-like) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005742 | 3.17865016081e-06 | 1.0 | TOMM40L TOMM40 TOMM22 | mitochondrial outer membrane translocase complex |
| CORUM:6498 | 3.35600554376e-06 | 0.666666666667 | TOMM40 TOMM22 | TOM7 120K intermediate assembly complex (TOM7, TOM22, TOM40), mitochondrial |
| GO:0098799 | 1.49850650438e-05 | 1.0 | TOMM40L TOMM40 TOMM22 | outer mitochondrial membrane protein complex |
| CORUM:6497 | 3.35555483123e-05 | 0.666666666667 | TOMM40 TOMM22 | TOM complex (TOM5, TOM6, TOM7, TOM20, TOM22, TOM40, TOM70), mitochondrial |
| GO:0008320 | 4.13224520905e-05 | 1.0 | TOMM40L TOMM40 TOMM22 | protein transmembrane transporter activity |
| GO:0022884 | 5.08584025729e-05 | 1.0 | TOMM40L TOMM40 TOMM22 | macromolecule transmembrane transporter activity |
| GO:0140318 | 8.80032001664e-05 | 1.0 | TOMM40L TOMM40 TOMM22 | protein transporter activity |
| GO:1904680 | 0.000208882724853 | 1.0 | TOMM40L TOMM40 TOMM22 | peptide transmembrane transporter activity |
| KEGG:05014 | 0.000569740713521 | 0.666666666667 | TOMM40L TOMM40 | Amyotrophic lateral sclerosis (ALS) |
| GO:0042887 | 0.000594407580071 | 1.0 | TOMM40L TOMM40 TOMM22 | amide transmembrane transporter activity |
| REAC:R-HSA-5205685 | 0.00114404160216 | 0.666666666667 | TOMM40 TOMM22 | Pink/Parkin Mediated Mitophagy |
| REAC:R-HSA-5205647 | 0.00184610965854 | 0.666666666667 | TOMM40 TOMM22 | Mitophagy |
| GO:0006626 | 0.0106693663112 | 1.0 | TOMM40L TOMM40 TOMM22 | protein targeting to mitochondrion |
| REAC:R-HSA-1268020 | 0.0118200826291 | 0.666666666667 | TOMM40 TOMM22 | Mitochondrial protein import |
| REAC:R-HSA-1632852 | 0.0249521708712 | 0.666666666667 | TOMM40 TOMM22 | Macroautophagy |
| GO:0005741 | 0.0268132763851 | 1.0 | TOMM40L TOMM40 TOMM22 | mitochondrial outer membrane |
| GO:0072655 | 0.0281650200706 | 1.0 | TOMM40L TOMM40 TOMM22 | establishment of protein localization to mitochondrion |
| GO:0070585 | 0.0295614464955 | 1.0 | TOMM40L TOMM40 TOMM22 | protein localization to mitochondrion |
| GO:0031968 | 0.0340260876928 | 1.0 | TOMM40L TOMM40 TOMM22 | organelle outer membrane |
| GO:0019867 | 0.0348113051011 | 1.0 | TOMM40L TOMM40 TOMM22 | outer membrane |
| REAC:R-HSA-9612973 | 0.0350118981581 | 0.666666666667 | TOMM40 TOMM22 | Autophagy |
| GO:0017038 | 0.043337807111 | 1.0 | TOMM40L TOMM40 TOMM22 | protein import |
| CORUM:3092 | 0.0499776345577 | 0.333333333333 | TOMM40 | APP-TOM40 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TOMM22 | TOMM40L | 0.988 | 0.902 | bioplex (TOMM22) bioplex_WMM |
| TOMM40 | TOMM22 | 0.277 | 0.486 | bioplex (TOMM22) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| TOMM40 | TOMM40L | 0.007 | 0.007 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05418 has an average edge precision of 0.465 which is ranked 2762 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TOMM40 | HuMAP2_02063 HuMAP2_05418 |
| TOMM22 | HuMAP2_02953 HuMAP2_03665 HuMAP2_04822 HuMAP2_05177 HuMAP2_05418 |
| TOMM40L | HuMAP2_02953 HuMAP2_03665 HuMAP2_04822 HuMAP2_05177 HuMAP2_05418 |