hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_05422

Confidence: Very High

Genename	Protein Name	Links
PCLAF	PCNA-associated factor (Hepatitis C virus NS5A-transactivated protein 9) (HCV NS5A-transactivated protein 9) (Overexpressed in anaplastic thyroid carcinoma 1) (OEATC-1) (PCNA-associated factor of 15 kDa) (PAF15) (p15PAF) (PCNA-clamp-associated factor)	UniProt NCBI
FEN1	Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1)	UniProt NCBI
PCNA	Proliferating cell nuclear antigen (PCNA) (Cyclin)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:1039	3.35600554376e-06	0.666666666667	PCLAF PCNA	PCNA-PAF complex
KEGG:03410	0.000221829243661	0.666666666667	PCNA FEN1	Base excision repair
KEGG:03030	0.000281708396768	0.666666666667	PCNA FEN1	DNA replication
REAC:R-HSA-174437	0.000301184970683	0.666666666667	PCNA FEN1	Removal of the Flap Intermediate from the C-strand
REAC:R-HSA-174414	0.000368098478948	0.666666666667	PCNA FEN1	Processive synthesis on the C-strand of the telomere
REAC:R-HSA-69166	0.00060895383853	0.666666666667	PCNA FEN1	Removal of the Flap Intermediate
REAC:R-HSA-69183	0.000702607572674	0.666666666667	PCNA FEN1	Processive synthesis on the lagging strand
REAC:R-HSA-69186	0.00127110038679	0.666666666667	PCNA FEN1	Lagging Strand Synthesis
REAC:R-HSA-5651801	0.00140483748394	0.666666666667	PCNA FEN1	PCNA-Dependent Long Patch Base Excision Repair
REAC:R-HSA-174417	0.00184610965854	0.666666666667	PCNA FEN1	Telomere C-strand (Lagging Strand) Synthesis
REAC:R-HSA-110373	0.00200655101382	0.666666666667	PCNA FEN1	Resolution of AP sites via the multiple-nucleotide patch replacement pathway
REAC:R-HSA-73894	0.00245537461814	1.0	FEN1 PCLAF PCNA	DNA Repair
WP:WP4016	0.0028706736774	0.666666666667	PCNA FEN1	DNA IR-damage and cellular response via ATR
REAC:R-HSA-180786	0.00290884705451	0.666666666667	PCNA FEN1	Extension of Telomeres
REAC:R-HSA-5656169	0.00310931782116	0.666666666667	PCLAF PCNA	Termination of translesion DNA synthesis
REAC:R-HSA-69190	0.0033164570092	0.666666666667	PCNA FEN1	DNA strand elongation
REAC:R-HSA-73933	0.00397787610966	0.666666666667	PCNA FEN1	Resolution of Abasic Sites (AP sites)
REAC:R-HSA-110313	0.0046992786316	0.666666666667	PCLAF PCNA	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
REAC:R-HSA-73893	0.00722314394396	0.666666666667	PCLAF PCNA	DNA Damage Bypass
GO:0009411	0.0206993698472	1.0	FEN1 PCLAF PCNA	response to UV
REAC:R-HSA-157579	0.0216163677069	0.666666666667	PCNA FEN1	Telomere Maintenance
REAC:R-HSA-73884	0.0249521708712	0.666666666667	PCNA FEN1	Base Excision Repair
CORUM:2231	0.0249904952816	0.333333333333	PCNA	PCNA homotrimer complex
REAC:R-HSA-73886	0.0385024292001	0.666666666667	PCNA FEN1	Chromosome Maintenance
KEGG:03450	0.043317794065	0.333333333333	FEN1	Non-homologous end-joining
REAC:R-HSA-69239	0.0459783176444	0.666666666667	PCNA FEN1	Synthesis of DNA
CORUM:314	0.0499776345577	0.333333333333	PCNA	PCNA-p21 complex
CORUM:1040	0.0499776345577	0.333333333333	PCLAF	p33ING1b-PCNA complex
CORUM:1163	0.0499776345577	0.333333333333	PCNA	ING1-PCNA complex
CORUM:7282	0.0499776345577	0.333333333333	FEN1	FEN1-WRN complex
MIRNA:hsa-miR-24-3p	0.0499784525791	1.0	FEN1 PCLAF PCNA	hsa-miR-24-3p

Edges

Protein 1	Protein 2	Score	Precision	Evidence
PCLAF	PCNA	0.997	0.933	hein_WMM bioplex (PCNA) bioplex_WMM hein (PCNA)
FEN1	PCNA	0.984	0.899	hein_WMM bioplex (FEN1) bioplex_WMM youn_WMM hein (FEN1,PCNA) gupta_WMM boldt_WMM treiber_WMM
FEN1	PCLAF	0.008	0.012	hein_WMM WMM_only

Images

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Complex HuMAP2_05422 has an average edge precision of 0.615 which is ranked 1865 out of all 6965 complexes.

Related Complexes

Genename	Complexes
PCLAF	HuMAP2_00775 HuMAP2_04364 HuMAP2_05422 HuMAP2_05853 HuMAP2_06224
FEN1	HuMAP2_00386 HuMAP2_01543 HuMAP2_05422 HuMAP2_06224 HuMAP2_06766
PCNA	HuMAP2_00775 HuMAP2_05422 HuMAP2_06224

hu.MAP 2.0: Complex View

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Complex: HuMAP2_05422