hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05425
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| EPHA1 | Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH) | UniProt NCBI |
| TTC3 | E3 ubiquitin-protein ligase TTC3 (EC 2.3.2.27) (Protein DCRR1) (RING finger protein 105) (RING-type E3 ubiquitin transferase TTC3) (TPR repeat protein D) (Tetratricopeptide repeat protein 3) (TPR repeat protein 3) | UniProt NCBI |
| ZC3H7A | Zinc finger CCCH domain-containing protein 7A | UniProt NCBI |
| SMG1 | Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (61E3.4) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) | UniProt NCBI |
| USP34 | Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) | UniProt NCBI |
| SMG8 | Protein SMG8 (Amplified in breast cancer gene 2 protein) (Protein smg-8 homolog) | UniProt NCBI |
| SMG9 | Protein SMG9 (Protein SMG-9) | UniProt NCBI |
| ZC3H7B | Zinc finger CCCH domain-containing protein 7B (Rotavirus 'X'-associated non-structural protein) (RoXaN) | UniProt NCBI |
| ZNF214 | Zinc finger protein 214 (BWSCR2-associated zinc finger protein 1) (BAZ-1) | UniProt NCBI |
| DIAPH3 | Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (MDia2) | UniProt NCBI |
| ESPNL | Espin-like protein | UniProt NCBI |
| RNF214 | RING finger protein 214 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-975957 | 0.0214984853946 | 0.25 | SMG9 SMG1 SMG8 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
| REAC:R-HSA-927802 | 0.0214984853946 | 0.25 | SMG9 SMG1 SMG8 | Nonsense-Mediated Decay (NMD) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SMG1 | RNF214 | 0.762 | 0.749 | youn (RNF214) youn_WMM |
| SMG1 | EPHA1 | 0.333 | 0.524 | bioplex (EPHA1) bioplex_WMM |
| ZC3H7A | RNF214 | 0.174 | 0.433 | youn (RNF214,ZC3H7A) youn_WMM treiber_WMM |
| SMG9 | EPHA1 | 0.147 | 0.408 | bioplex (EPHA1) bioplex_WMM |
| EPHA1 | ESPNL | 0.123 | 0.395 | bioplex (EPHA1) bioplex_WMM |
| SMG1 | ZC3H7A | 0.098 | 0.358 | youn (ZC3H7A) youn_WMM |
| SMG9 | SMG8 | 0.078 | 0.352 | hein_WMM bioplex_WMM youn_WMM hein (SMG9) |
| USP34 | EPHA1 | 0.077 | 0.353 | bioplex (EPHA1) bioplex_WMM |
| ZC3H7B | RNF214 | 0.064 | 0.349 | youn (RNF214) youn_WMM treiber_WMM |
| DIAPH3 | EPHA1 | 0.04 | 0.269 | bioplex (EPHA1) bioplex_WMM |
| SMG9 | SMG1 | 0.038 | 0.264 | hein_WMM bioplex_WMM youn_WMM hein (SMG9) |
| TTC3 | RNF214 | 0.034 | 0.263 | youn (RNF214) youn_WMM |
| ZNF214 | USP34 | 0.027 | 0.228 | bioplex (ZNF214) bioplex_WMM |
| SMG8 | RNF214 | 0.022 | 0.207 | youn (RNF214) bioplex_WMM youn_WMM |
| ZC3H7A | ZC3H7B | 0.012 | 0.147 | youn (ZC3H7A) youn_WMM treiber_WMM |
| SMG8 | EPHA1 | 0.012 | 0.146 | bioplex (EPHA1) bioplex_WMM |
| SMG8 | ZC3H7A | 0.011 | 0.142 | youn (ZC3H7A) youn_WMM |
| SMG9 | ESPNL | 0.009 | 0.095 | bioplex_WMM WMM_only |
| SMG1 | ESPNL | 0.009 | 0.095 | bioplex_WMM WMM_only |
| SMG8 | SMG1 | 0.009 | 0.093 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| DIAPH3 | SMG9 | 0.008 | 0.082 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| DIAPH3 | SMG1 | 0.008 | 0.066 | bioplex_WMM youn_WMM WMM_only |
| DIAPH3 | ESPNL | 0.008 | 0.047 | bioplex_WMM WMM_only |
| USP34 | ESPNL | 0.008 | 0.028 | bioplex_WMM WMM_only |
| USP34 | SMG1 | 0.008 | 0.028 | bioplex_WMM WMM_only |
| SMG9 | USP34 | 0.008 | 0.028 | bioplex_WMM WMM_only |
| SMG9 | ZC3H7B | 0.007 | 0.007 | youn_WMM gupta_WMM WMM_only |
| SMG8 | ESPNL | 0.007 | 0.009 | bioplex_WMM WMM_only |
| SMG8 | ZC3H7B | 0.007 | 0.01 | youn_WMM WMM_only |
| SMG1 | ZC3H7B | 0.007 | 0.008 | youn_WMM WMM_only |
| TTC3 | ZC3H7B | 0.007 | 0.011 | youn_WMM WMM_only |
| SMG8 | TTC3 | 0.007 | 0.008 | youn_WMM WMM_only |
| SMG1 | TTC3 | 0.007 | 0.005 | youn_WMM WMM_only boldt_WMM |
| SMG9 | TTC3 | 0.007 | 0.004 | youn_WMM WMM_only |
| SMG9 | RNF214 | 0.007 | 0.009 | youn (RNF214) youn_WMM |
| DIAPH3 | ZC3H7A | 0.007 | 0.003 | youn_WMM WMM_only |
| DIAPH3 | RNF214 | 0.007 | 0.001 | youn_WMM WMM_only |
| DIAPH3 | ZC3H7B | 0.007 | 0.001 | youn_WMM gupta_WMM WMM_only |
| DIAPH3 | TTC3 | 0.007 | 0.001 | youn_WMM WMM_only |
| DIAPH3 | USP34 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| DIAPH3 | SMG8 | 0.007 | 0.008 | bioplex_WMM youn_WMM WMM_only |
| SMG8 | USP34 | 0.006 | 0.003 | bioplex_WMM WMM_only |
| SMG9 | ZC3H7A | 0.006 | 0.005 | youn (ZC3H7A) youn_WMM |
| TTC3 | ZC3H7A | 0.006 | 0.004 | youn (ZC3H7A) youn_WMM |
Images
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Complex HuMAP2_05425 has an average edge precision of 0.142 which is ranked 6761 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| EPHA1 | HuMAP2_05425 HuMAP2_06549 |
| TTC3 | HuMAP2_03856 HuMAP2_05425 |
| ZC3H7A | HuMAP2_03856 HuMAP2_04158 HuMAP2_05425 |
| SMG1 | HuMAP2_03856 HuMAP2_04158 HuMAP2_05425 HuMAP2_05445 |
| USP34 | HuMAP2_02544 HuMAP2_05425 HuMAP2_05666 HuMAP2_06549 |
| SMG8 | HuMAP2_02435 HuMAP2_05425 |
| SMG9 | HuMAP2_02435 HuMAP2_05425 HuMAP2_06549 |
| ZC3H7B | HuMAP2_03856 HuMAP2_04158 HuMAP2_05425 |
| ZNF214 | HuMAP2_02006 HuMAP2_02544 HuMAP2_05411 HuMAP2_05425 |
| DIAPH3 | HuMAP2_00923 HuMAP2_00970 HuMAP2_04916 HuMAP2_05425 HuMAP2_05824 HuMAP2_05952 HuMAP2_06549 |
| ESPNL | HuMAP2_05425 HuMAP2_06549 |
| RNF214 | HuMAP2_03856 HuMAP2_04158 HuMAP2_05425 HuMAP2_05445 |