hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_05426
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| P4HB | Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55) | UniProt NCBI |
| CALR | Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) | UniProt NCBI |
| P4HA2 | Prolyl 4-hydroxylase subunit alpha-2 (4-PH alpha-2) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04141 | 0.00544616782939 | 0.666666666667 | CALR P4HB | Protein processing in endoplasmic reticulum |
| REAC:R-HSA-1650814 | 0.0126269885924 | 0.666666666667 | P4HB P4HA2 | Collagen biosynthesis and modifying enzymes |
| GO:0004656 | 0.0135228859698 | 0.666666666667 | P4HB P4HA2 | procollagen-proline 4-dioxygenase activity |
| REAC:R-HSA-1474290 | 0.0232544758505 | 0.666666666667 | P4HB P4HA2 | Collagen formation |
| CORUM:5217 | 0.0249904952816 | 0.333333333333 | CALR | Calreticulin homo-oligomer complex |
| MIRNA:hsa-miR-6782-5p | 0.0367514176092 | 0.666666666667 | CALR P4HB | hsa-miR-6782-5p |
| GO:0019798 | 0.0378589948753 | 0.666666666667 | P4HB P4HA2 | procollagen-proline dioxygenase activity |
| GO:0031545 | 0.0378589948753 | 0.666666666667 | P4HB P4HA2 | peptidyl-proline 4-dioxygenase activity |
| GO:0018401 | 0.0378589948753 | 0.666666666667 | P4HB P4HA2 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline |
| CORUM:472 | 0.0499776345577 | 0.333333333333 | P4HB | Prolyl 4-hydroxylase (alpha(I)-type) |
| CORUM:474 | 0.0499776345577 | 0.333333333333 | P4HB | Prolyl 4-hydroxylase (alpha(III)-type) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CALR | P4HB | 0.98 | 0.896 | bioplex (P4HB) bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| P4HA2 | P4HB | 0.98 | 0.896 | hein_WMM bioplex (P4HA2,P4HB) bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| CALR | P4HA2 | 0.007 | 0.003 | bioplex (P4HA2) bioplex_WMM gupta_WMM treiber_WMM |
Images
Click to enlarge
Complex HuMAP2_05426 has an average edge precision of 0.598 which is ranked 1951 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| P4HB | HuMAP2_00504 HuMAP2_02463 HuMAP2_02974 HuMAP2_05426 |
| CALR | HuMAP2_00278 HuMAP2_01351 HuMAP2_05426 HuMAP2_05943 |
| P4HA2 | HuMAP2_00316 HuMAP2_00504 HuMAP2_02463 HuMAP2_02558 HuMAP2_04896 HuMAP2_05426 |