hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_05432
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| COL5A1 | Collagen alpha-1(V) chain | UniProt NCBI |
| COL4A5 | Collagen alpha-5(IV) chain | UniProt NCBI |
| COL8A2 | Collagen alpha-2(VIII) chain (Endothelial collagen) | UniProt NCBI |
| COL2A1 | Collagen alpha-1(II) chain (Alpha-1 type II collagen) [Cleaved into: Collagen alpha-1(II) chain; Chondrocalcin] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8948216 | 7.4593283151e-09 | 1.0 | COL2A1 COL5A1 COL4A5 COL8A2 | Collagen chain trimerization |
| REAC:R-HSA-2022090 | 3.33094636765e-08 | 1.0 | COL2A1 COL5A1 COL4A5 COL8A2 | Assembly of collagen fibrils and other multimeric structures |
| REAC:R-HSA-1442490 | 4.42235299624e-08 | 1.0 | COL2A1 COL5A1 COL4A5 COL8A2 | Collagen degradation |
| REAC:R-HSA-1650814 | 5.05908621651e-08 | 1.0 | COL2A1 COL5A1 COL4A5 COL8A2 | Collagen biosynthesis and modifying enzymes |
| REAC:R-HSA-216083 | 1.10228940689e-07 | 1.0 | COL2A1 COL5A1 COL4A5 COL8A2 | Integrin cell surface interactions |
| REAC:R-HSA-1474290 | 1.74986096744e-07 | 1.0 | COL2A1 COL5A1 COL4A5 COL8A2 | Collagen formation |
| REAC:R-HSA-1474228 | 9.67478990718e-07 | 1.0 | COL2A1 COL5A1 COL4A5 COL8A2 | Degradation of the extracellular matrix |
| GO:0030020 | 1.43702054144e-06 | 1.0 | COL2A1 COL5A1 COL4A5 COL8A2 | extracellular matrix structural constituent conferring tensile strength |
| REAC:R-HSA-419037 | 6.68850838342e-06 | 0.75 | COL5A1 COL4A5 COL2A1 | NCAM1 interactions |
| KEGG:04974 | 1.81045500953e-05 | 0.75 | COL5A1 COL4A5 COL2A1 | Protein digestion and absorption |
| REAC:R-HSA-1474244 | 1.8775434359e-05 | 1.0 | COL2A1 COL5A1 COL4A5 COL8A2 | Extracellular matrix organization |
| REAC:R-HSA-375165 | 2.64063995051e-05 | 0.75 | COL5A1 COL4A5 COL2A1 | NCAM signaling for neurite out-growth |
| REAC:R-HSA-186797 | 3.34108196159e-05 | 0.75 | COL5A1 COL4A5 COL2A1 | Signaling by PDGF |
| REAC:R-HSA-3000171 | 3.94070508018e-05 | 0.75 | COL5A1 COL4A5 COL2A1 | Non-integrin membrane-ECM interactions |
| REAC:R-HSA-3000178 | 6.16010596593e-05 | 0.75 | COL5A1 COL4A5 COL2A1 | ECM proteoglycans |
| GO:0005201 | 0.000260251848503 | 1.0 | COL2A1 COL5A1 COL4A5 COL8A2 | extracellular matrix structural constituent |
| GO:0098644 | 0.000296207880886 | 0.75 | COL5A1 COL4A5 COL2A1 | complex of collagen trimers |
| GO:0005581 | 0.00147288799354 | 0.75 | COL5A1 COL4A5 COL2A1 | collagen trimer |
| GO:0044420 | 0.00281780772825 | 0.75 | COL5A1 COL4A5 COL2A1 | extracellular matrix component |
| GO:0005788 | 0.00334428065319 | 1.0 | COL2A1 COL5A1 COL4A5 COL8A2 | endoplasmic reticulum lumen |
| REAC:R-HSA-8874081 | 0.00379215175563 | 0.5 | COL5A1 COL2A1 | MET activates PTK2 signaling |
| GO:0030198 | 0.00406662724791 | 1.0 | COL2A1 COL5A1 COL4A5 COL8A2 | extracellular matrix organization |
| MIRNA:hsa-miR-29b-3p | 0.00582349734998 | 0.75 | COL5A1 COL4A5 COL2A1 | hsa-miR-29b-3p |
| KEGG:04512 | 0.00597612422935 | 0.5 | COL2A1 COL4A5 | ECM-receptor interaction |
| HP:0004328 | 0.00637600916282 | 1.0 | COL2A1 COL5A1 COL4A5 COL8A2 | Abnormal anterior eye segment morphology |
| REAC:R-HSA-8875878 | 0.00667602194349 | 0.5 | COL5A1 COL2A1 | MET promotes cell motility |
| GO:0043062 | 0.00733907004762 | 1.0 | COL2A1 COL5A1 COL4A5 COL8A2 | extracellular structure organization |
| GO:0062023 | 0.008399180142 | 1.0 | COL2A1 COL5A1 COL4A5 COL8A2 | collagen-containing extracellular matrix |
| HP:0000545 | 0.00903044796583 | 0.75 | COL5A1 COL4A5 COL2A1 | Myopia |
| HP:0001083 | 0.011244112798 | 0.5 | COL5A1 COL2A1 | Ectopia lentis |
| REAC:R-HSA-9006934 | 0.0147563350021 | 0.75 | COL5A1 COL4A5 COL2A1 | Signaling by Receptor Tyrosine Kinases |
| GO:0031012 | 0.0175518684514 | 1.0 | COL2A1 COL5A1 COL4A5 COL8A2 | extracellular matrix |
| HP:0002758 | 0.023433582519 | 0.5 | COL5A1 COL2A1 | Osteoarthritis |
| REAC:R-HSA-6806834 | 0.0262582706021 | 0.5 | COL5A1 COL2A1 | Signaling by MET |
| HP:0100625 | 0.0266188198793 | 0.5 | COL5A1 COL2A1 | Enlarged thorax |
| HP:0000539 | 0.0278183273244 | 0.75 | COL5A1 COL4A5 COL2A1 | Abnormality of refraction |
| REAC:R-HSA-422475 | 0.0294332368862 | 0.75 | COL5A1 COL4A5 COL2A1 | Axon guidance |
| KEGG:04510 | 0.0350038155474 | 0.5 | COL2A1 COL4A5 | Focal adhesion |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| COL5A1 | COL8A2 | 0.413 | 0.571 | bioplex (COL8A2) bioplex_WMM |
| COL4A5 | COL8A2 | 0.149 | 0.41 | bioplex (COL8A2) bioplex_WMM |
| COL8A2 | COL2A1 | 0.077 | 0.352 | bioplex (COL8A2) bioplex_WMM |
| COL5A1 | COL2A1 | 0.012 | 0.146 | bioplex_WMM WMM_only |
| COL4A5 | COL2A1 | 0.011 | 0.142 | bioplex_WMM WMM_only |
| COL5A1 | COL4A5 | 0.009 | 0.114 | bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_05432 has an average edge precision of 0.289 which is ranked 4762 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| COL5A1 | HuMAP2_00859 HuMAP2_04566 HuMAP2_05432 HuMAP2_05533 |
| COL4A5 | HuMAP2_04238 HuMAP2_05080 HuMAP2_05161 HuMAP2_05432 |
| COL8A2 | HuMAP2_04566 HuMAP2_05161 HuMAP2_05432 HuMAP2_05533 |
| COL2A1 | HuMAP2_04566 HuMAP2_05161 HuMAP2_05432 HuMAP2_05533 |