hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_05439

Confidence: High

Genename	Protein Name	Links
RSL1D1	Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1)	UniProt NCBI
BRIX1	Ribosome biogenesis protein BRX1 homolog (Brix domain-containing protein 2)	UniProt NCBI
NSA2	Ribosome biogenesis protein NSA2 homolog (Hairy cell leukemia protein 1) (TGF-beta-inducible nuclear protein 1)	UniProt NCBI
NIFK	MKI67 FHA domain-interacting nucleolar phosphoprotein (Nucleolar phosphoprotein Nopp34) (Nucleolar protein interacting with the FHA domain of pKI-67) (hNIFK)	UniProt NCBI
LLPH	Protein LLP homolog (Protein LAPS18-like)	UniProt NCBI
RRS1	Ribosome biogenesis regulatory protein homolog	UniProt NCBI
SURF6	Surfeit locus protein 6	UniProt NCBI
EBNA1BP2	Probable rRNA-processing protein EBP2 (EBNA1-binding protein 2) (Nucleolar protein p40)	UniProt NCBI
DKC1	H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1)	UniProt NCBI
RPF2	Ribosome production factor 2 homolog (Brix domain-containing protein 1) (Ribosome biogenesis protein RPF2 homolog)	UniProt NCBI
HP1BP3	Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74)	UniProt NCBI
RBM28	RNA-binding protein 28 (RNA-binding motif protein 28)	UniProt NCBI
DDX24	ATP-dependent RNA helicase DDX24 (EC 3.6.4.13) (DEAD box protein 24)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0005730	1.72346259131e-08	0.846153846154	RPF2 SURF6 NIFK BRIX1 RRS1 DDX24 RBM28 DKC1 LLPH RSL1D1 EBNA1BP2	nucleolus
GO:0003723	3.45957724408e-07	0.923076923077	RPF2 EBNA1BP2 NIFK BRIX1 RRS1 DDX24 NSA2 RBM28 DKC1 LLPH RSL1D1 SURF6	RNA binding
GO:0042273	3.76146866278e-07	0.461538461538	RPF2 SURF6 RRS1 BRIX1 RSL1D1 EBNA1BP2	ribosomal large subunit biogenesis
GO:0003676	4.68056529178e-06	1.0	RPF2 EBNA1BP2 NIFK BRIX1 RRS1 DDX24 NSA2 RBM28 DKC1 LLPH RSL1D1 HP1BP3 SURF6	nucleic acid binding
GO:0042254	1.76271139486e-05	0.538461538462	RPF2 SURF6 BRIX1 RRS1 DKC1 RSL1D1 EBNA1BP2	ribosome biogenesis
CORUM:3055	8.09705880373e-05	0.307692307692	RBM28 RSL1D1 EBNA1BP2 BRIX1	Nop56p-associated pre-rRNA complex
GO:1901363	8.3744606393e-05	1.0	RPF2 EBNA1BP2 NIFK BRIX1 RRS1 DDX24 NSA2 RBM28 DKC1 LLPH RSL1D1 HP1BP3 SURF6	heterocyclic compound binding
GO:0097159	0.000104907710199	1.0	RPF2 EBNA1BP2 NIFK BRIX1 RRS1 DDX24 NSA2 RBM28 DKC1 LLPH RSL1D1 HP1BP3 SURF6	organic cyclic compound binding
GO:0016072	0.000245006967535	0.461538461538	RPF2 EBNA1BP2 RRS1 DKC1 RSL1D1 NIFK	rRNA metabolic process
GO:0022613	0.000416371439784	0.538461538462	RPF2 SURF6 BRIX1 RRS1 DKC1 RSL1D1 EBNA1BP2	ribonucleoprotein complex biogenesis
TF:M08913_1	0.000496773298051	0.923076923077	RPF2 EBNA1BP2 NIFK BRIX1 RRS1 DDX24 NSA2 RBM28 DKC1 LLPH RSL1D1 SURF6	Factor: FLI-1; motif: NAYTTCCGGT; match class: 1
MIRNA:hsa-miR-7847-3p	0.000794949908582	0.384615384615	RBM28 BRIX1 EBNA1BP2 LLPH HP1BP3	hsa-miR-7847-3p
MIRNA:hsa-miR-6880-5p	0.000903213626945	0.384615384615	RBM28 BRIX1 EBNA1BP2 LLPH HP1BP3	hsa-miR-6880-5p
MIRNA:hsa-miR-6851-5p	0.00134324548415	0.384615384615	RBM28 BRIX1 EBNA1BP2 LLPH HP1BP3	hsa-miR-6851-5p
MIRNA:hsa-miR-3689d	0.00163178378396	0.384615384615	RBM28 BRIX1 EBNA1BP2 LLPH HP1BP3	hsa-miR-3689d
TF:M01752_1	0.00478459101006	0.923076923077	RPF2 EBNA1BP2 NIFK BRIX1 RRS1 DDX24 NSA2 RBM28 DKC1 LLPH RSL1D1 SURF6	Factor: ERG; motif: ACCGGAART; match class: 1
TF:M02059_1	0.00511228588043	0.923076923077	RPF2 EBNA1BP2 NIFK BRIX1 RRS1 DDX24 NSA2 RBM28 DKC1 LLPH RSL1D1 SURF6	Factor: ELK-1; motif: ACCGGAAGTN; match class: 1
TF:M08231_1	0.00862570985723	0.692307692308	RPF2 EBNA1BP2 BRIX1 RRS1 DDX24 RBM28 NSA2 DKC1 RSL1D1	Factor: Elk-1:T-bet; motif: TCACACCGGAAGNN; match class: 1
TF:M03988_1	0.00964942381052	0.846153846154	RPF2 EBNA1BP2 NIFK BRIX1 RRS1 DDX24 NSA2 RBM28 DKC1 RSL1D1 SURF6	Factor: FLI1; motif: ACCGGAARTN; match class: 1
GO:0006364	0.0119094274499	0.384615384615	RRS1 RSL1D1 RPF2 EBNA1BP2 DKC1	rRNA processing
GO:0043232	0.0171540958607	0.923076923077	RPF2 SURF6 NIFK DKC1 RRS1 DDX24 RBM28 HP1BP3 LLPH RSL1D1 BRIX1 EBNA1BP2	intracellular non-membrane-bounded organelle
GO:0043228	0.0172676648201	0.923076923077	RPF2 SURF6 NIFK DKC1 RRS1 DDX24 RBM28 HP1BP3 LLPH RSL1D1 BRIX1 EBNA1BP2	non-membrane-bounded organelle
TF:M02066_1	0.0176994282249	0.769230769231	RPF2 EBNA1BP2 NIFK RRS1 RBM28 NSA2 DKC1 LLPH RSL1D1 SURF6	Factor: PEA3; motif: RCCGGAAGYN; match class: 1
GO:0030684	0.0183614143254	0.307692307692	RRS1 RSL1D1 NSA2 EBNA1BP2	preribosome
HPA:006020_13	0.022395339618	0.307692307692	RSL1D1 RPF2 NIFK DKC1	caudate; neuronal cells[Supported,High]
GO:0034660	0.0268263102654	0.461538461538	RPF2 EBNA1BP2 RRS1 DKC1 RSL1D1 NIFK	ncRNA metabolic process
HPA:041010_12	0.0269123923438	0.384615384615	RSL1D1 RPF2 NIFK HP1BP3 DKC1	skeletal muscle; myocytes[Supported,Medium]
HPA:022020_12	0.0366335970167	0.384615384615	RSL1D1 RPF2 NIFK HP1BP3 DKC1	hippocampus; neuronal cells[Supported,Medium]
TF:M02071_1	0.0370019611377	0.923076923077	RPF2 EBNA1BP2 NIFK BRIX1 RRS1 DDX24 NSA2 RBM28 DKC1 LLPH RSL1D1 SURF6	Factor: ETV7; motif: NCCGGAANNN; match class: 1
HPA:035010_11	0.0424116413615	0.384615384615	RSL1D1 RPF2 NIFK HP1BP3 DKC1	placenta; decidual cells[Supported,Low]
HPA:031010_10	0.0427033148315	0.384615384615	RSL1D1 RPF2 NIFK HP1BP3 DKC1	ovary; follicle cells[Supported,Not detected]
HPA:031010_12	0.0427910397879	0.307692307692	RSL1D1 NIFK HP1BP3 DKC1	ovary; follicle cells[Supported,Medium]
GO:0031981	0.043521186735	0.923076923077	RPF2 SURF6 NIFK DKC1 RRS1 DDX24 RBM28 HP1BP3 LLPH RSL1D1 BRIX1 EBNA1BP2	nuclear lumen
GO:0030687	0.0455389078467	0.230769230769	RRS1 NSA2 EBNA1BP2	preribosome, large subunit precursor

Edges

Protein 1	Protein 2	Score	Precision	Evidence
BRIX1	EBNA1BP2	1.0	0.949	hein_WMM bioplex (EBNA1BP2) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
RRS1	RPF2	1.0	0.949	bioplex (RRS1) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
HP1BP3	DKC1	1.0	0.949	bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
RRS1	EBNA1BP2	0.999	0.949	bioplex (EBNA1BP2,RRS1) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
EBNA1BP2	RPF2	0.998	0.939	bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
EBNA1BP2	RBM28	0.989	0.906	hein_WMM bioplex (EBNA1BP2) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
DKC1	EBNA1BP2	0.985	0.899	hein_WMM bioplex (EBNA1BP2) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
BRIX1	RPF2	0.98	0.896	bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
EBNA1BP2	LLPH	0.979	0.895	bioplex_WMM youn_WMM fraction treiber_WMM
RBM28	NIFK	0.979	0.895	bioplex (NIFK) bioplex_WMM Guru youn_WMM gupta_WMM fraction
RPF2	NSA2	0.978	0.893	bioplex (NSA2) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
RRS1	BRIX1	0.973	0.886	bioplex (RRS1) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
DKC1	BRIX1	0.973	0.886	bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
DKC1	RRS1	0.961	0.869	bioplex (RRS1) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
BRIX1	LLPH	0.958	0.863	bioplex_WMM youn_WMM fraction
DKC1	RPF2	0.948	0.856	bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
RRS1	DDX24	0.943	0.856	bioplex (RRS1) bioplex_WMM youn_WMM gupta_WMM fraction
EBNA1BP2	DDX24	0.932	0.846	hein_WMM bioplex (EBNA1BP2) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
RRS1	NSA2	0.917	0.84	bioplex (NSA2,RRS1) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
RPF2	NIFK	0.855	0.793	bioplex (NIFK) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
NIFK	NSA2	0.854	0.793	bioplex (NIFK) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
EBNA1BP2	RSL1D1	0.825	0.774	hein_WMM bioplex (EBNA1BP2) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
EBNA1BP2	NSA2	0.808	0.768	bioplex (NSA2) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
DKC1	DDX24	0.766	0.749	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
SURF6	EBNA1BP2	0.758	0.747	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
HP1BP3	RBM28	0.74	0.739	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
SURF6	RPF2	0.598	0.668	bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
HP1BP3	EBNA1BP2	0.553	0.645	hein_WMM bioplex (EBNA1BP2,HP1BP3) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
RRS1	NIFK	0.5	0.621	bioplex (NIFK,RRS1) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
LLPH	RPF2	0.495	0.62	bioplex_WMM youn_WMM fraction treiber_WMM
SURF6	DKC1	0.489	0.617	bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
RRS1	LLPH	0.463	0.6	bioplex_WMM youn_WMM fraction treiber_WMM
BRIX1	DDX24	0.448	0.592	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
SURF6	BRIX1	0.447	0.59	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
DDX24	NIFK	0.443	0.587	bioplex (NIFK) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
DDX24	RPF2	0.429	0.577	bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
HP1BP3	BRIX1	0.407	0.566	hein_WMM bioplex (HP1BP3) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
SURF6	RRS1	0.388	0.551	bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
RRS1	RBM28	0.383	0.55	bioplex (RRS1) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
DKC1	NIFK	0.318	0.51	bioplex (NIFK) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
HP1BP3	RSL1D1	0.291	0.492	hein_WMM bioplex (HP1BP3) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
HP1BP3	RRS1	0.284	0.489	bioplex (RRS1) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
SURF6	LLPH	0.277	0.485	bioplex_WMM youn_WMM fraction
EBNA1BP2	NIFK	0.243	0.468	bioplex (NIFK) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
SURF6	NSA2	0.212	0.461	bioplex (NSA2) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
BRIX1	NSA2	0.186	0.441	bioplex (NSA2) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
DKC1	LLPH	0.112	0.38	bioplex_WMM youn_WMM fraction
LLPH	NIFK	0.109	0.374	bioplex (NIFK) bioplex_WMM youn_WMM treiber_WMM
HP1BP3	NSA2	0.106	0.371	bioplex (NSA2) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
RRS1	RSL1D1	0.103	0.366	bioplex (RRS1) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
DKC1	RSL1D1	0.099	0.359	bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
LLPH	NSA2	0.063	0.346	bioplex (NSA2) bioplex_WMM youn_WMM treiber_WMM
RSL1D1	NSA2	0.06	0.336	bioplex (NSA2) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
BRIX1	RBM28	0.058	0.323	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
RBM28	NSA2	0.055	0.309	bioplex (NSA2) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
SURF6	HP1BP3	0.053	0.301	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
RPF2	RBM28	0.053	0.302	bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
DKC1	NSA2	0.052	0.3	bioplex (NSA2) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
DDX24	RBM28	0.052	0.302	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
BRIX1	RSL1D1	0.047	0.29	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
SURF6	RBM28	0.045	0.292	hein_WMM bioplex_WMM youn_WMM WMM_only treiber_WMM
RSL1D1	NIFK	0.043	0.269	bioplex (NIFK) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
HP1BP3	NIFK	0.031	0.236	bioplex (NIFK) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
BRIX1	NIFK	0.031	0.238	bioplex (NIFK) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
DDX24	NSA2	0.029	0.23	bioplex (NSA2) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
SURF6	RSL1D1	0.029	0.23	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
HP1BP3	RPF2	0.026	0.215	bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
RPF2	RSL1D1	0.024	0.215	bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
RSL1D1	RBM28	0.02	0.185	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
SURF6	NIFK	0.02	0.188	bioplex (NIFK) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
HP1BP3	LLPH	0.019	0.183	bioplex_WMM youn_WMM WMM_only
HP1BP3	DDX24	0.019	0.185	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
SURF6	DDX24	0.017	0.173	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
DKC1	RBM28	0.016	0.155	bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
LLPH	RBM28	0.015	0.144	bioplex_WMM youn_WMM WMM_only
LLPH	DDX24	0.014	0.136	bioplex_WMM youn_WMM WMM_only
LLPH	RSL1D1	0.013	0.15	bioplex_WMM youn_WMM WMM_only
DDX24	RSL1D1	0.005	0.012	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM

Images

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Complex HuMAP2_05439 has an average edge precision of 0.533 which is ranked 2313 out of all 6965 complexes.

Related Complexes

Genename	Complexes
RSL1D1	HuMAP2_00300 HuMAP2_04505 HuMAP2_05439 HuMAP2_06948
BRIX1	HuMAP2_00275 HuMAP2_02076 HuMAP2_04505 HuMAP2_04628 HuMAP2_05439 HuMAP2_05727 HuMAP2_06347
NSA2	HuMAP2_01083 HuMAP2_01732 HuMAP2_05439 HuMAP2_05727 HuMAP2_05877 HuMAP2_06347
NIFK	HuMAP2_00537 HuMAP2_00561 HuMAP2_00988 HuMAP2_01071 HuMAP2_01509 HuMAP2_05122 HuMAP2_05439 HuMAP2_05727 HuMAP2_06347
LLPH	HuMAP2_00275 HuMAP2_04505 HuMAP2_05439 HuMAP2_06347
RRS1	HuMAP2_00275 HuMAP2_00379 HuMAP2_00537 HuMAP2_02076 HuMAP2_02911 HuMAP2_04505 HuMAP2_04750 HuMAP2_05439 HuMAP2_05727 HuMAP2_06347
SURF6	HuMAP2_00008 HuMAP2_00275 HuMAP2_00537 HuMAP2_00574 HuMAP2_00650 HuMAP2_05439 HuMAP2_06347
EBNA1BP2	HuMAP2_00275 HuMAP2_00537 HuMAP2_02076 HuMAP2_04505 HuMAP2_04628 HuMAP2_05439 HuMAP2_05727 HuMAP2_06347
DKC1	HuMAP2_00041 HuMAP2_00275 HuMAP2_00537 HuMAP2_01057 HuMAP2_01164 HuMAP2_01512 HuMAP2_01695 HuMAP2_02076 HuMAP2_03262 HuMAP2_05439 HuMAP2_05727 HuMAP2_06347
RPF2	HuMAP2_00275 HuMAP2_00537 HuMAP2_02076 HuMAP2_02911 HuMAP2_04750 HuMAP2_05439 HuMAP2_05727 HuMAP2_06347 HuMAP2_06681
HP1BP3	HuMAP2_00041 HuMAP2_00537 HuMAP2_00574 HuMAP2_01164 HuMAP2_01512 HuMAP2_05004 HuMAP2_05439 HuMAP2_06347
RBM28	HuMAP2_00537 HuMAP2_00574 HuMAP2_01509 HuMAP2_02076 HuMAP2_05439 HuMAP2_05727 HuMAP2_06347
DDX24	HuMAP2_00275 HuMAP2_00537 HuMAP2_01057 HuMAP2_04505 HuMAP2_05439 HuMAP2_05727

hu.MAP 2.0: Complex View

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Complex: HuMAP2_05439