hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05443
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SAFB | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | UniProt NCBI |
| MDC1 | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | UniProt NCBI |
| TOP1 | DNA topoisomerase 1 (EC 5.6.2.2) (DNA topoisomerase I) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3108232 | 0.000336595223393 | 1.0 | SAFB MDC1 TOP1 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-2990846 | 0.000374667089817 | 1.0 | SAFB MDC1 TOP1 | SUMOylation |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MDC1 | SAFB | 0.076 | 0.356 | youn_WMM gupta_WMM fraction |
| TOP1 | SAFB | 0.038 | 0.263 | bioplex_WMM youn_WMM gupta_WMM fraction |
| MDC1 | TOP1 | 0.008 | 0.025 | youn_WMM gupta_WMM WMM_only |
Images
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Complex HuMAP2_05443 has an average edge precision of 0.215 which is ranked 5953 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SAFB | HuMAP2_01402 HuMAP2_02136 HuMAP2_02261 HuMAP2_05443 |
| MDC1 | HuMAP2_00089 HuMAP2_00974 HuMAP2_01103 HuMAP2_02945 HuMAP2_04010 HuMAP2_05156 HuMAP2_05443 HuMAP2_06754 HuMAP2_06775 |
| TOP1 | HuMAP2_00903 HuMAP2_05443 |