hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_05446

Confidence: Medium High

Genename	Protein Name	Links
SDHAF2	Succinate dehydrogenase assembly factor 2, mitochondrial (SDH assembly factor 2) (SDHAF2)	UniProt NCBI
PDZRN3	E3 ubiquitin-protein ligase PDZRN3 (EC 2.3.2.27) (Ligand of Numb protein X 3) (PDZ domain-containing RING finger protein 3) (RING-type E3 ubiquitin transferase PDZRN3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3)	UniProt NCBI
SDHA	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC 1.3.5.1) (Flavoprotein subunit of complex II) (Fp)	UniProt NCBI
SDHAF3	Succinate dehydrogenase assembly factor 3, mitochondrial (SDH assembly factor 3) (SDHAF3)	UniProt NCBI
SDHAF4	Succinate dehydrogenase assembly factor 4, mitochondrial (SDH assembly factor 4) (SDHAF4)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0034552	3.6323771075e-06	0.6	SDHAF3 SDHAF2 SDHAF4	respiratory chain complex II assembly
GO:0034553	3.6323771075e-06	0.6	SDHAF3 SDHAF2 SDHAF4	mitochondrial respiratory chain complex II assembly
HP:0010532	0.0025531267598	0.4	SDHAF2 SDHA	Paroxysmal vertigo
HP:0008629	0.0025531267598	0.4	SDHAF2 SDHA	Pulsatile tinnitus
HP:0006737	0.0025531267598	0.4	SDHAF2 SDHA	Extraadrenal pheochromocytoma
HP:0003639	0.0025531267598	0.4	SDHAF2 SDHA	Elevated urinary epinephrine
HP:0002864	0.0025531267598	0.4	SDHAF2 SDHA	Paraganglioma of head and neck
HP:0000740	0.0025531267598	0.4	SDHAF2 SDHA	Episodic paroxysmal anxiety
HP:0003345	0.0030633405246	0.4	SDHAF2 SDHA	Elevated urinary norepinephrine
HP:0012222	0.0030633405246	0.4	SDHAF2 SDHA	Arachnoid hemangiomatosis
HP:0009711	0.0030633405246	0.4	SDHAF2 SDHA	Retinal capillary hemangioma
HP:0006748	0.0030633405246	0.4	SDHAF2 SDHA	Adrenal pheochromocytoma
HP:0003574	0.0030633405246	0.4	SDHAF2 SDHA	Positive regitine blocking test
HP:0001095	0.0030633405246	0.4	SDHAF2 SDHA	Hypertensive retinopathy
HP:0100642	0.0030633405246	0.4	SDHAF2 SDHA	Neoplasm of the adrenal medulla
HP:0011979	0.00361982515692	0.4	SDHAF2 SDHA	Elevated urinary dopamine
HP:0002331	0.00361982515692	0.4	SDHAF2 SDHA	Recurrent paroxysmal headache
HP:0002640	0.00361982515692	0.4	SDHAF2 SDHA	Hypertension associated with pheochromocytoma
HP:0010797	0.00422256197273	0.4	SDHAF2 SDHA	Hemangioblastoma
HP:0003528	0.00422256197273	0.4	SDHAF2 SDHA	Elevated calcitonin
GO:0000104	0.00450823411379	0.4	SDHA SDHAF4	succinate dehydrogenase activity
GO:0008177	0.00450823411379	0.4	SDHA SDHAF4	succinate dehydrogenase (ubiquinone) activity
HP:0002668	0.00487153229182	0.4	SDHAF2 SDHA	Paraganglioma
HP:0002666	0.00487153229182	0.4	SDHAF2 SDHA	Pheochromocytoma
HP:0031284	0.00630809873773	0.4	SDHAF2 SDHA	Flushing
HP:0001069	0.00630809873773	0.4	SDHAF2 SDHA	Episodic hyperhidrosis
HP:0009594	0.00630809873773	0.4	SDHAF2 SDHA	Retinal hamartoma
HP:0011703	0.00709565752293	0.4	SDHAF2 SDHA	Sinus tachycardia
HP:0011976	0.00880923289202	0.4	SDHAF2 SDHA	Elevated urinary catecholamines
HP:0011281	0.00880923289202	0.4	SDHAF2 SDHA	Abnormality of urine catecholamine concentration
HP:0030670	0.0107072942689	0.4	SDHAF2 SDHA	Hamartoma of the orbital region
HP:0001293	0.0107072942689	0.4	SDHAF2 SDHA	Cranial nerve compression
HP:0010568	0.0107072942689	0.4	SDHAF2 SDHA	Hamartoma of the eye
GO:0016635	0.0135228859698	0.4	SDHA SDHAF4	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor
GO:0006121	0.0135228859698	0.4	SDHAF2 SDHA	mitochondrial electron transport, succinate to ubiquinone
HP:0100634	0.0162585949147	0.4	SDHAF2 SDHA	Neuroendocrine neoplasm
HP:0025269	0.0162585949147	0.4	SDHAF2 SDHA	Panic attack
HP:0032148	0.0175069025895	0.4	SDHAF2 SDHA	Episodic pain
HP:0001605	0.0175069025895	0.4	SDHAF2 SDHA	Vocal cord paralysis
HP:0031801	0.0175069025895	0.4	SDHAF2 SDHA	Vocal cord dysfunction
HP:0002574	0.0175069025895	0.4	SDHAF2 SDHA	Episodic abdominal pain
HP:0100631	0.0188011826397	0.4	SDHAF2 SDHA	Neoplasm of the adrenal gland
HP:0100530	0.0201414164419	0.4	SDHAF2 SDHA	Abnormal calcium-phosphate regulating hormone level
HP:0000360	0.0259615168254	0.4	SDHAF2 SDHA	Tinnitus
HP:0000526	0.0259615168254	0.4	SDHAF2 SDHA	Aniridia
GO:0045257	0.0270421395626	0.4	SDHA SDHAF4	succinate dehydrogenase complex (ubiquinone)
GO:0006105	0.0270421395626	0.4	SDHAF3 SDHA	succinate metabolic process
GO:0045283	0.0270421395626	0.4	SDHA SDHAF4	fumarate reductase complex
GO:0045281	0.0270421395626	0.4	SDHA SDHAF4	succinate dehydrogenase complex
GO:0045273	0.0270421395626	0.4	SDHA SDHAF4	respiratory chain complex II
GO:0005749	0.0270421395626	0.4	SDHA SDHAF4	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)
HP:0100012	0.0291468055875	0.4	SDHAF2 SDHA	Neoplasm of the eye
HP:0003072	0.0379116132621	0.4	SDHAF2 SDHA	Hypercalcemia
HP:0100007	0.0379116132621	0.4	SDHAF2 SDHA	Neoplasm of the peripheral nervous system
HP:0001342	0.0398018408038	0.4	SDHAF2 SDHA	Cerebral hemorrhage
HP:0011702	0.0478196851342	0.4	SDHAF2 SDHA	Abnormal electrophysiology of sinoatrial node origin
HP:0002018	0.0499382869304	0.4	SDHAF2 SDHA	Nausea

Edges

Protein 1	Protein 2	Score	Precision	Evidence
SDHAF2	SDHA	0.983	0.899	hein_WMM bioplex (SDHA) bioplex_WMM hein (SDHAF2)
SDHA	SDHAF4	0.939	0.85	bioplex (SDHA) bioplex_WMM fraction
SDHAF3	SDHAF4	0.178	0.436	bioplex (SDHAF3) bioplex_WMM
PDZRN3	SDHA	0.098	0.358	bioplex (SDHA) bioplex_WMM gupta_WMM boldt_WMM
SDHAF2	SDHAF4	0.008	0.091	bioplex_WMM WMM_only
SDHAF2	SDHAF3	0.008	0.087	bioplex_WMM WMM_only
PDZRN3	SDHAF2	0.008	0.067	bioplex_WMM WMM_only
PDZRN3	SDHAF4	0.008	0.04	bioplex_WMM WMM_only
PDZRN3	SDHAF3	0.008	0.025	bioplex_WMM WMM_only
SDHA	SDHAF3	0.007	0.008	bioplex (SDHA,SDHAF3) bioplex_WMM

Images

Click to enlarge

Complex HuMAP2_05446 has an average edge precision of 0.286 which is ranked 4797 out of all 6965 complexes.

Related Complexes

Genename	Complexes
SDHAF2	HuMAP2_03232 HuMAP2_04642 HuMAP2_04832 HuMAP2_05446
PDZRN3	HuMAP2_01087 HuMAP2_03232 HuMAP2_03997 HuMAP2_04832 HuMAP2_05446 HuMAP2_05666 HuMAP2_07016
SDHA	HuMAP2_03232 HuMAP2_04642 HuMAP2_04832 HuMAP2_05446
SDHAF3	HuMAP2_04609 HuMAP2_04832 HuMAP2_05446
SDHAF4	HuMAP2_04609 HuMAP2_04642 HuMAP2_04832 HuMAP2_05446

hu.MAP 2.0: Complex View

Search for a protein

Complex: HuMAP2_05446