hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05450
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| VPS36 | Vacuolar protein-sorting-associated protein 36 (ELL-associated protein of 45 kDa) (ESCRT-II complex subunit VPS36) | UniProt NCBI |
| VPS25 | Vacuolar protein-sorting-associated protein 25 (hVps25) (Dermal papilla-derived protein 9) (ELL-associated protein of 20 kDa) (ESCRT-II complex subunit VPS25) | UniProt NCBI |
| SNF8 | Vacuolar-sorting protein SNF8 (ELL-associated protein of 30 kDa) (ESCRT-II complex subunit VPS22) (hVps22) | UniProt NCBI |
| SUGP1 | SURP and G-patch domain-containing protein 1 (RNA-binding protein RBP) (Splicing factor 4) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1187 | 6.75231048499e-10 | 0.75 | VPS25 VPS36 SNF8 | ESCRT-II complex |
| GO:0000814 | 3.63274304092e-07 | 0.75 | VPS25 VPS36 SNF8 | ESCRT II complex |
| GO:0043328 | 1.45302402969e-06 | 0.75 | VPS25 VPS36 SNF8 | protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
| GO:0032511 | 3.6323771075e-06 | 0.75 | VPS25 VPS36 SNF8 | late endosome to vacuole transport via multivesicular body sorting pathway |
| REAC:R-HSA-917729 | 6.06176646053e-06 | 0.75 | VPS25 VPS36 SNF8 | Endosomal Sorting Complex Required For Transport (ESCRT) |
| GO:0045324 | 0.000103844122491 | 0.75 | VPS25 VPS36 SNF8 | late endosome to vacuole transport |
| GO:0032509 | 0.000351729129078 | 0.75 | VPS25 VPS36 SNF8 | endosome transport via multivesicular body sorting pathway |
| GO:0043162 | 0.000413778117181 | 0.75 | VPS25 VPS36 SNF8 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
| KEGG:04144 | 0.000539397470166 | 0.75 | VPS25 VPS36 SNF8 | Endocytosis |
| GO:0036452 | 0.000834605087859 | 0.75 | VPS25 VPS36 SNF8 | ESCRT complex |
| GO:0071985 | 0.00106129291317 | 0.75 | VPS25 VPS36 SNF8 | multivesicular body sorting pathway |
| GO:0036258 | 0.00147288799354 | 0.75 | VPS25 VPS36 SNF8 | multivesicular body assembly |
| GO:0036257 | 0.00163061517788 | 0.75 | VPS25 VPS36 SNF8 | multivesicular body organization |
| GO:0072666 | 0.00358246159338 | 0.75 | VPS25 VPS36 SNF8 | establishment of protein localization to vacuole |
| GO:0072665 | 0.00898751047669 | 0.75 | VPS25 VPS36 SNF8 | protein localization to vacuole |
| GO:0007032 | 0.0198185309013 | 0.75 | VPS25 VPS36 SNF8 | endosome organization |
| HPA:003010_23 | 0.0338599256539 | 0.75 | SNF8 VPS36 SUGP1 | bone marrow; hematopoietic cells[Approved,High] |
| REAC:R-HSA-199991 | 0.0426366599823 | 0.75 | VPS25 VPS36 SNF8 | Membrane Trafficking |
| HPA:039010_23 | 0.0430648308081 | 0.75 | SNF8 VPS36 SUGP1 | salivary gland; glandular cells[Approved,High] |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| VPS36 | VPS25 | 1.0 | 0.949 | hein_WMM bioplex (VPS36) bioplex_WMM Guru hein (VPS25) fraction |
| VPS36 | SNF8 | 0.999 | 0.949 | hein_WMM bioplex (VPS36) bioplex_WMM hein (SNF8) fraction |
| VPS25 | SNF8 | 0.999 | 0.948 | hein_WMM bioplex_WMM hein (VPS25) fraction |
| SNF8 | SUGP1 | 0.087 | 0.353 | fraction |
| VPS25 | SUGP1 | 0.087 | 0.352 | gupta_WMM fraction |
| VPS36 | SUGP1 | 0.019 | 0.183 | fraction |
Images
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Complex HuMAP2_05450 has an average edge precision of 0.622 which is ranked 1814 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| VPS36 | HuMAP2_00588 HuMAP2_03699 HuMAP2_03998 HuMAP2_04660 HuMAP2_05450 HuMAP2_05663 |
| VPS25 | HuMAP2_03699 HuMAP2_03998 HuMAP2_05450 HuMAP2_05663 |
| SNF8 | HuMAP2_03699 HuMAP2_03998 HuMAP2_05450 HuMAP2_05663 |
| SUGP1 | HuMAP2_03998 HuMAP2_05450 HuMAP2_05663 |