hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05452
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TBL1XR1 | F-box-like/WD repeat-containing protein TBL1XR1 (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1) (Transducin beta-like 1X-related protein 1) | UniProt NCBI |
| ANKRD11 | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | UniProt NCBI |
| NCOR1 | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | UniProt NCBI |
| TBL1X | F-box-like/WD repeat-containing protein TBL1X (SMAP55) (Transducin beta-like protein 1X) (Transducin-beta-like protein 1, X-linked) | UniProt NCBI |
| TBL1Y | F-box-like/WD repeat-containing protein TBL1Y (Transducin beta-like protein 1Y) (Transducin-beta-like protein 1, Y-linked) | UniProt NCBI |
| NCOR2 | Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor) | UniProt NCBI |
| GPS2 | G protein pathway suppressor 2 (GPS-2) | UniProt NCBI |
| HDAC3 | Histone deacetylase 3 (HD3) (EC 3.5.1.98) (RPD3-2) (SMAP45) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9022537 | 3.27778728289e-19 | 0.75 | HDAC3 GPS2 NCOR2 TBL1XR1 TBL1X NCOR1 | Loss of MECP2 binding ability to the NCoR/SMRT complex |
| REAC:R-HSA-9005891 | 6.88018322587e-17 | 0.75 | HDAC3 GPS2 NCOR2 TBL1XR1 TBL1X NCOR1 | Loss of function of MECP2 in Rett syndrome |
| REAC:R-HSA-9005895 | 6.88018322587e-17 | 0.75 | HDAC3 GPS2 NCOR2 TBL1XR1 TBL1X NCOR1 | Pervasive developmental disorders |
| CORUM:58 | 4.24766632997e-16 | 0.625 | HDAC3 NCOR2 TBL1XR1 GPS2 TBL1X | SMRT complex |
| CORUM:741 | 4.24766632997e-16 | 0.625 | NCOR1 HDAC3 TBL1XR1 GPS2 TBL1X | NCOR-HDAC3 complex |
| CORUM:15 | 2.54817186464e-15 | 0.625 | NCOR1 HDAC3 TBL1XR1 GPS2 TBL1X | NCOR complex |
| CORUM:2183 | 1.06951346208e-13 | 0.625 | NCOR1 HDAC3 TBL1XR1 GPS2 TBL1X | Kaiso-NCOR complex |
| REAC:R-HSA-9022692 | 1.55289366836e-13 | 0.75 | HDAC3 GPS2 NCOR2 TBL1XR1 TBL1X NCOR1 | Regulation of MECP2 expression and activity |
| REAC:R-HSA-8986944 | 7.4843047216e-12 | 0.75 | HDAC3 GPS2 NCOR2 TBL1XR1 TBL1X NCOR1 | Transcriptional Regulation by MECP2 |
| REAC:R-HSA-350054 | 1.30844262732e-10 | 0.625 | NCOR1 NCOR2 TBL1XR1 TBL1X HDAC3 | Notch-HLH transcription pathway |
| REAC:R-HSA-3214815 | 2.47351291348e-10 | 0.75 | HDAC3 GPS2 NCOR2 TBL1XR1 TBL1X NCOR1 | HDACs deacetylate histones |
| WP:WP4312 | 5.00960144571e-10 | 0.625 | NCOR1 NCOR2 TBL1XR1 GPS2 TBL1X | Rett syndrome causing genes |
| REAC:R-HSA-1989781 | 5.52739554669e-10 | 0.75 | HDAC3 GPS2 NCOR2 TBL1XR1 TBL1X NCOR1 | PPARA activates gene expression |
| REAC:R-HSA-400206 | 5.85507759238e-10 | 0.75 | HDAC3 GPS2 NCOR2 TBL1XR1 TBL1X NCOR1 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| REAC:R-HSA-2122947 | 1.55595136195e-09 | 0.625 | NCOR1 NCOR2 TBL1XR1 TBL1X HDAC3 | NOTCH1 Intracellular Domain Regulates Transcription |
| REAC:R-HSA-2644603 | 4.63078234664e-09 | 0.625 | NCOR1 NCOR2 TBL1XR1 TBL1X HDAC3 | Signaling by NOTCH1 in Cancer |
| REAC:R-HSA-2644606 | 4.63078234664e-09 | 0.625 | NCOR1 NCOR2 TBL1XR1 TBL1X HDAC3 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| REAC:R-HSA-2894862 | 4.63078234664e-09 | 0.625 | NCOR1 NCOR2 TBL1XR1 TBL1X HDAC3 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| REAC:R-HSA-2644602 | 4.63078234664e-09 | 0.625 | NCOR1 NCOR2 TBL1XR1 TBL1X HDAC3 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| REAC:R-HSA-2894858 | 4.63078234664e-09 | 0.625 | NCOR1 NCOR2 TBL1XR1 TBL1X HDAC3 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| CORUM:752 | 4.70911134935e-09 | 0.375 | HDAC3 TBL1X NCOR2 | SMRT core complex |
| CORUM:1188 | 4.70911134935e-09 | 0.375 | HDAC3 TBL1X NCOR2 | SMRT core complex |
| GO:0000118 | 6.23929662158e-09 | 0.75 | HDAC3 NCOR2 TBL1X TBL1Y TBL1XR1 NCOR1 | histone deacetylase complex |
| GO:0017053 | 9.15979827959e-09 | 0.75 | HDAC3 GPS2 NCOR2 TBL1XR1 TBL1X NCOR1 | transcriptional repressor complex |
| REAC:R-HSA-1980143 | 1.22808304139e-08 | 0.625 | NCOR1 NCOR2 TBL1XR1 TBL1X HDAC3 | Signaling by NOTCH1 |
| CORUM:7480 | 1.8831701816e-08 | 0.375 | NCOR1 NCOR2 HDAC3 | HDAC3-H1.3-SMRT-N-Cor complex |
| GO:0003714 | 2.51864098357e-08 | 0.875 | HDAC3 GPS2 NCOR2 TBL1X TBL1Y TBL1XR1 NCOR1 | transcription corepressor activity |
| REAC:R-HSA-381340 | 3.39235898889e-08 | 0.625 | NCOR1 NCOR2 TBL1XR1 TBL1X HDAC3 | Transcriptional regulation of white adipocyte differentiation |
| REAC:R-HSA-4839726 | 1.58171178648e-07 | 0.75 | HDAC3 GPS2 NCOR2 TBL1XR1 TBL1X NCOR1 | Chromatin organization |
| REAC:R-HSA-3247509 | 1.58171178648e-07 | 0.75 | HDAC3 GPS2 NCOR2 TBL1XR1 TBL1X NCOR1 | Chromatin modifying enzymes |
| CORUM:1505 | 1.64652925394e-07 | 0.375 | NCOR1 NCOR2 HDAC3 | NCOR2 complex |
| REAC:R-HSA-2151201 | 1.38087801691e-06 | 0.5 | NCOR1 TBL1XR1 TBL1X HDAC3 | Transcriptional activation of mitochondrial biogenesis |
| REAC:R-HSA-400253 | 4.04643017452e-06 | 0.5 | NCOR1 TBL1XR1 TBL1X HDAC3 | Circadian Clock |
| CORUM:5614 | 5.34544376683e-06 | 0.375 | HDAC3 TBL1XR1 TBL1Y | Emerin complex 32 |
| REAC:R-HSA-157118 | 6.43593800277e-06 | 0.625 | NCOR1 NCOR2 TBL1XR1 TBL1X HDAC3 | Signaling by NOTCH |
| CORUM:5426 | 1.16880143691e-05 | 0.25 | HDAC3 ANKRD11 | ANCO1-HDAC3 complex |
| GO:0003712 | 1.21391794778e-05 | 0.875 | HDAC3 GPS2 NCOR2 TBL1X TBL1Y TBL1XR1 NCOR1 | transcription coregulator activity |
| REAC:R-HSA-1592230 | 1.38679282104e-05 | 0.5 | NCOR1 TBL1XR1 TBL1X HDAC3 | Mitochondrial biogenesis |
| REAC:R-HSA-556833 | 2.81057808349e-05 | 0.75 | HDAC3 GPS2 NCOR2 TBL1XR1 TBL1X NCOR1 | Metabolism of lipids |
| REAC:R-HSA-5663202 | 5.40657897134e-05 | 0.625 | NCOR1 NCOR2 TBL1XR1 TBL1X HDAC3 | Diseases of signal transduction |
| GO:0019216 | 5.43837651415e-05 | 0.75 | HDAC3 GPS2 NCOR2 TBL1XR1 TBL1X NCOR1 | regulation of lipid metabolic process |
| REAC:R-HSA-1368071 | 0.000134251754877 | 0.25 | NCOR1 HDAC3 | NR1D1 (REV-ERBA) represses gene expression |
| REAC:R-HSA-1643685 | 0.000292759547505 | 0.75 | HDAC3 GPS2 NCOR2 TBL1XR1 TBL1X NCOR1 | Disease |
| CORUM:0000000 | 0.000356401437906 | 1.0 | HDAC3 GPS2 NCOR2 ANKRD11 TBL1X TBL1XR1 NCOR1 TBL1Y | CORUM root |
| REAC:R-HSA-212436 | 0.000485403591864 | 0.75 | HDAC3 GPS2 NCOR2 TBL1XR1 TBL1X NCOR1 | Generic Transcription Pathway |
| CORUM:1413 | 0.000524831455609 | 0.25 | NCOR1 HDAC3 | NCOR1 complex |
| GO:0016575 | 0.000620237823973 | 0.5 | HDAC3 TBL1Y TBL1X TBL1XR1 | histone deacetylation |
| REAC:R-HSA-73857 | 0.000921019711578 | 0.75 | HDAC3 GPS2 NCOR2 TBL1XR1 TBL1X NCOR1 | RNA Polymerase II Transcription |
| REAC:R-HSA-1852241 | 0.00140977665905 | 0.5 | NCOR1 TBL1XR1 TBL1X HDAC3 | Organelle biogenesis and maintenance |
| GO:0006476 | 0.0015436837415 | 0.5 | HDAC3 TBL1Y TBL1X TBL1XR1 | protein deacetylation |
| REAC:R-HSA-74160 | 0.00174657105004 | 0.75 | HDAC3 GPS2 NCOR2 TBL1XR1 TBL1X NCOR1 | Gene expression (Transcription) |
| GO:0098732 | 0.00193552303911 | 0.5 | HDAC3 TBL1Y TBL1X TBL1XR1 | macromolecule deacylation |
| GO:0035601 | 0.00193552303911 | 0.5 | HDAC3 TBL1Y TBL1X TBL1XR1 | protein deacylation |
| KEGG:04310 | 0.00244581534875 | 0.375 | TBL1Y TBL1X TBL1XR1 | Wnt signaling pathway |
| GO:0000122 | 0.00346139232029 | 0.75 | HDAC3 GPS2 NCOR2 TBL1XR1 TBL1X NCOR1 | negative regulation of transcription by RNA polymerase II |
| GO:0072686 | 0.00533098594204 | 0.5 | NCOR1 TBL1XR1 TBL1X HDAC3 | mitotic spindle |
| REAC:R-HSA-1368082 | 0.00681930164511 | 0.25 | TBL1X TBL1XR1 | RORA activates gene expression |
| REAC:R-HSA-1266738 | 0.00759021602886 | 0.625 | NCOR1 NCOR2 TBL1XR1 TBL1X HDAC3 | Developmental Biology |
| REAC:R-HSA-2173795 | 0.0112612209329 | 0.25 | NCOR1 NCOR2 | Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| GO:0140110 | 0.0113789666228 | 0.875 | HDAC3 GPS2 NCOR2 TBL1X TBL1Y TBL1XR1 NCOR1 | transcription regulator activity |
| REAC:R-HSA-1368108 | 0.0144543373882 | 0.25 | TBL1X TBL1XR1 | BMAL1:CLOCK,NPAS2 activates circadian gene expression |
| GO:0046329 | 0.0147863948461 | 0.375 | NCOR1 GPS2 HDAC3 | negative regulation of JNK cascade |
| REAC:R-HSA-1430728 | 0.0157286835681 | 0.75 | HDAC3 GPS2 NCOR2 TBL1XR1 TBL1X NCOR1 | Metabolism |
| WP:WP61 | 0.0193921266924 | 0.25 | NCOR1 NCOR2 | Notch Signaling Pathway |
| GO:0006357 | 0.0225750987374 | 0.875 | HDAC3 GPS2 NCOR2 TBL1X TBL1Y TBL1XR1 NCOR1 | regulation of transcription by RNA polymerase II |
| REAC:R-HSA-383280 | 0.0295328318157 | 0.25 | NCOR1 NCOR2 | Nuclear Receptor transcription pathway |
| GO:0032873 | 0.0301968453576 | 0.375 | NCOR1 GPS2 HDAC3 | negative regulation of stress-activated MAPK cascade |
| GO:0070303 | 0.0301968453576 | 0.375 | NCOR1 GPS2 HDAC3 | negative regulation of stress-activated protein kinase signaling cascade |
| REAC:R-HSA-2426168 | 0.0311651665682 | 0.25 | TBL1X TBL1XR1 | Activation of gene expression by SREBF (SREBP) |
| REAC:R-HSA-2173793 | 0.039977733682 | 0.25 | NCOR1 NCOR2 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| GO:0006366 | 0.0475044023837 | 0.875 | HDAC3 GPS2 NCOR2 TBL1X TBL1Y TBL1XR1 NCOR1 | transcription by RNA polymerase II |
| WP:WP138 | 0.0477902143581 | 0.25 | NCOR1 NCOR2 | Androgen receptor signaling pathway |
| GO:0045892 | 0.048081979475 | 0.75 | HDAC3 GPS2 NCOR2 TBL1XR1 TBL1X NCOR1 | negative regulation of transcription, DNA-templated |
| GO:1903507 | 0.0487422565067 | 0.75 | HDAC3 GPS2 NCOR2 TBL1XR1 TBL1X NCOR1 | negative regulation of nucleic acid-templated transcription |
| GO:1902679 | 0.0490751968456 | 0.75 | HDAC3 GPS2 NCOR2 TBL1XR1 TBL1X NCOR1 | negative regulation of RNA biosynthetic process |
| CORUM:6244 | 0.0497224828424 | 0.125 | HDAC3 | AJUBA-GFI1-HDAC3 complex |
| CORUM:7487 | 0.0497224828424 | 0.125 | HDAC3 | DTNBP1(1A)-HDAC3 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NCOR2 | GPS2 | 1.0 | 0.949 | bioplex (GPS2) bioplex_WMM youn_WMM gupta_WMM |
| HDAC3 | GPS2 | 0.944 | 0.856 | bioplex (GPS2) bioplex_WMM youn_WMM gupta_WMM |
| GPS2 | ANKRD11 | 0.916 | 0.84 | bioplex (GPS2) bioplex_WMM youn_WMM |
| TBL1XR1 | GPS2 | 0.915 | 0.839 | bioplex (GPS2) bioplex_WMM youn_WMM gupta_WMM |
| NCOR1 | GPS2 | 0.888 | 0.818 | bioplex (GPS2) bioplex_WMM youn_WMM gupta_WMM |
| TBL1Y | NCOR2 | 0.87 | 0.804 | bioplex (TBL1Y) bioplex_WMM |
| GPS2 | TBL1X | 0.706 | 0.727 | bioplex (GPS2) bioplex_WMM youn_WMM |
| TBL1Y | TBL1X | 0.681 | 0.709 | bioplex (TBL1Y) bioplex_WMM |
| TBL1Y | GPS2 | 0.664 | 0.699 | bioplex (TBL1Y) bioplex_WMM |
| TBL1Y | TBL1XR1 | 0.273 | 0.485 | bioplex (TBL1Y) bioplex_WMM |
| TBL1Y | NCOR1 | 0.235 | 0.47 | bioplex (TBL1Y) bioplex_WMM |
| TBL1Y | HDAC3 | 0.07 | 0.348 | bioplex (TBL1Y) bioplex_WMM |
| NCOR1 | HDAC3 | 0.014 | 0.137 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| NCOR1 | TBL1XR1 | 0.013 | 0.154 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| NCOR2 | TBL1X | 0.012 | 0.147 | bioplex_WMM youn_WMM WMM_only |
| NCOR2 | TBL1XR1 | 0.011 | 0.145 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| NCOR2 | NCOR1 | 0.011 | 0.139 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| TBL1XR1 | TBL1X | 0.011 | 0.145 | bioplex_WMM youn_WMM WMM_only |
| NCOR1 | TBL1X | 0.01 | 0.103 | bioplex_WMM youn_WMM WMM_only |
| NCOR2 | HDAC3 | 0.01 | 0.105 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| TBL1XR1 | HDAC3 | 0.009 | 0.113 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| NCOR2 | ANKRD11 | 0.009 | 0.105 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| ANKRD11 | TBL1X | 0.009 | 0.106 | bioplex_WMM youn_WMM WMM_only |
| TBL1XR1 | ANKRD11 | 0.008 | 0.095 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| HDAC3 | TBL1X | 0.008 | 0.089 | bioplex_WMM youn_WMM WMM_only |
| NCOR1 | ANKRD11 | 0.008 | 0.092 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| HDAC3 | ANKRD11 | 0.008 | 0.062 | bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_05452 has an average edge precision of 0.381 which is ranked 3518 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TBL1XR1 | HuMAP2_00929 HuMAP2_02514 HuMAP2_02763 HuMAP2_05428 HuMAP2_05452 |
| ANKRD11 | HuMAP2_02514 HuMAP2_05428 HuMAP2_05452 |
| NCOR1 | HuMAP2_00929 HuMAP2_02514 HuMAP2_02763 HuMAP2_05428 HuMAP2_05452 |
| TBL1X | HuMAP2_05428 HuMAP2_05452 |
| TBL1Y | HuMAP2_00648 HuMAP2_05428 HuMAP2_05452 |
| NCOR2 | HuMAP2_00648 HuMAP2_03841 HuMAP2_05428 HuMAP2_05452 |
| GPS2 | HuMAP2_02514 HuMAP2_03841 HuMAP2_05428 HuMAP2_05452 |
| HDAC3 | HuMAP2_02514 HuMAP2_05428 HuMAP2_05452 |