hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05462
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RPS6KA3 | Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) | UniProt NCBI |
| RPS6KA1 | Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) | UniProt NCBI |
| RPS6KA2 | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | UniProt NCBI |
| OBSL1 | Obscurin-like protein 1 | UniProt NCBI |
| MISP | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-199920 | 9.51308232652e-08 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | CREB phosphorylation |
| REAC:R-HSA-444257 | 9.51308232652e-08 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | RSK activation |
| REAC:R-HSA-881907 | 1.5207132982e-06 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Gastrin-CREB signalling pathway via PKC and MAPK |
| REAC:R-HSA-198753 | 4.17943282079e-06 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | ERK/MAPK targets |
| REAC:R-HSA-198725 | 6.24012216224e-06 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Nuclear Events (kinase and transcription factor activation) |
| REAC:R-HSA-442742 | 7.0533398358e-06 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling |
| REAC:R-HSA-450282 | 1.21879917622e-05 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | MAPK targets/ Nuclear events mediated by MAP kinases |
| GO:0004711 | 3.17736949706e-05 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | ribosomal protein S6 kinase activity |
| KEGG:04720 | 3.25178756029e-05 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Long-term potentiation |
| REAC:R-HSA-437239 | 3.84212387398e-05 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Recycling pathway of L1 |
| WP:WP477 | 7.07040269841e-05 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Cytoplasmic Ribosomal Proteins |
| KEGG:04914 | 7.32179527008e-05 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Progesterone-mediated oocyte maturation |
| REAC:R-HSA-450294 | 0.000107327354708 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | MAP kinase activation |
| WP:WP4321 | 0.000107720319002 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Thermogenesis |
| REAC:R-HSA-448424 | 0.000141520021869 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Interleukin-17 signaling |
| KEGG:04931 | 0.00014703288327 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Insulin resistance |
| REAC:R-HSA-187037 | 0.000167928044622 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Signaling by NTRK1 (TRKA) |
| REAC:R-HSA-438064 | 0.000167928044622 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Post NMDA receptor activation events |
| KEGG:04722 | 0.000169883843985 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Neurotrophin signaling pathway |
| KEGG:04114 | 0.000169883843985 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Oocyte meiosis |
| KEGG:05135 | 0.000194978614983 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Yersinia infection |
| WP:WP3915 | 0.000206095076976 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Angiopoietin Like Protein 8 Regulatory Pathway |
| REAC:R-HSA-168142 | 0.000238892911782 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-168176 | 0.000238892911782 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-975871 | 0.000238892911782 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-442755 | 0.00025697910325 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Activation of NMDA receptors and postsynaptic events |
| REAC:R-HSA-975138 | 0.00025697910325 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-168181 | 0.000266353842167 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-975155 | 0.000266353842167 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-168188 | 0.000306125075711 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-166058 | 0.000306125075711 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-168138 | 0.000306125075711 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-168164 | 0.000316649083447 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-166520 | 0.000327410819085 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Signaling by NTRKs |
| REAC:R-HSA-168179 | 0.000338412904811 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-181438 | 0.000338412904811 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-937061 | 0.000349657961729 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-166166 | 0.000349657961729 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | MyD88-independent TLR4 cascade |
| WP:WP481 | 0.000395472085416 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Insulin Signaling |
| KEGG:04150 | 0.000415558284387 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | mTOR signaling pathway |
| WP:WP437 | 0.000443577883382 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | EGF/EGFR Signaling Pathway |
| REAC:R-HSA-2559582 | 0.000519144712976 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Senescence-Associated Secretory Phenotype (SASP) |
| REAC:R-HSA-373760 | 0.000596598643168 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | L1CAM interactions |
| REAC:R-HSA-166016 | 0.000717394603045 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-416476 | 0.00102865345201 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | G alpha (q) signalling events |
| REAC:R-HSA-168898 | 0.00120028939708 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Toll-like Receptor Cascades |
| KEGG:04714 | 0.00127045127527 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Thermogenesis |
| KEGG:04010 | 0.00232977147301 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | MAPK signaling pathway |
| REAC:R-HSA-112314 | 0.00234614610155 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-2559583 | 0.00290844270817 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Cellular Senescence |
| WP:WP4566 | 0.00343593293187 | 0.4 | RPS6KA1 RPS6KA2 | Translation inhibitors in chronically activated PDGFRA cells |
| WP:WP304 | 0.00510552962608 | 0.4 | RPS6KA1 RPS6KA3 | Kit receptor signaling pathway |
| REAC:R-HSA-112315 | 0.005113781726 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Transmission across Chemical Synapses |
| REAC:R-HSA-112316 | 0.0172109299174 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Neuronal System |
| REAC:R-HSA-2262752 | 0.0291077226575 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Cellular responses to stress |
| REAC:R-HSA-9006934 | 0.0291077226575 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Signaling by Receptor Tyrosine Kinases |
| WP:WP2380 | 0.0301079862712 | 0.4 | RPS6KA1 RPS6KA3 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| REAC:R-HSA-8953897 | 0.0498194225693 | 0.6 | RPS6KA3 RPS6KA1 RPS6KA2 | Cellular responses to external stimuli |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MISP | RPS6KA3 | 0.137 | 0.407 | bioplex (MISP) bioplex_WMM |
| MISP | RPS6KA1 | 0.135 | 0.406 | bioplex (MISP) bioplex_WMM |
| MISP | RPS6KA2 | 0.085 | 0.35 | bioplex (MISP) bioplex_WMM |
| MISP | OBSL1 | 0.083 | 0.349 | bioplex (MISP) bioplex_WMM |
| RPS6KA2 | RPS6KA3 | 0.017 | 0.176 | bioplex_WMM WMM_only |
| RPS6KA1 | RPS6KA2 | 0.014 | 0.14 | bioplex_WMM WMM_only |
| RPS6KA1 | RPS6KA3 | 0.012 | 0.148 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| OBSL1 | RPS6KA1 | 0.007 | 0.003 | bioplex_WMM youn_WMM WMM_only |
| OBSL1 | RPS6KA3 | 0.007 | 0.008 | bioplex_WMM youn_WMM WMM_only |
| OBSL1 | RPS6KA2 | 0.007 | 0.002 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05462 has an average edge precision of 0.199 which is ranked 6192 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RPS6KA3 | HuMAP2_00566 HuMAP2_05297 HuMAP2_05462 HuMAP2_06014 HuMAP2_06605 |
| RPS6KA1 | HuMAP2_00566 HuMAP2_00821 HuMAP2_02828 HuMAP2_05297 HuMAP2_05462 |
| RPS6KA2 | HuMAP2_00566 HuMAP2_02828 HuMAP2_05297 HuMAP2_05462 |
| OBSL1 | HuMAP2_00566 HuMAP2_01116 HuMAP2_05297 HuMAP2_05462 |
| MISP | HuMAP2_00566 HuMAP2_02160 HuMAP2_05297 HuMAP2_05462 HuMAP2_05657 HuMAP2_06706 |