hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05468
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| LSM2 | U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (Small nuclear ribonuclear protein D homolog) (snRNP core Sm-like protein Sm-x5) | UniProt NCBI |
| LSM3 | U6 snRNA-associated Sm-like protein LSm3 | UniProt NCBI |
| LSM6 | U6 snRNA-associated Sm-like protein LSm6 | UniProt NCBI |
| LSM8 | U6 snRNA-associated Sm-like protein LSm8 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:562 | 1.58707183517e-12 | 1.0 | LSM2 LSM6 LSM3 LSM8 | LSm2-8 complex |
| GO:0120115 | 8.5384464732e-10 | 1.0 | LSM2 LSM6 LSM3 LSM8 | Lsm2-8 complex |
| GO:0005688 | 1.70768929464e-09 | 1.0 | LSM2 LSM6 LSM3 LSM8 | U6 snRNP |
| KEGG:03018 | 2.31843669078e-08 | 1.0 | LSM2 LSM6 LSM3 LSM8 | RNA degradation |
| CORUM:561 | 2.3628325482e-08 | 0.75 | LSM6 LSM3 LSM2 | LSm1-7 complex |
| KEGG:03040 | 2.052638918e-07 | 1.0 | LSM2 LSM6 LSM3 LSM8 | Spliceosome |
| REAC:R-HSA-430039 | 6.14088879325e-07 | 0.75 | LSM6 LSM3 LSM2 | mRNA decay by 5' to 3' exoribonuclease |
| GO:0097526 | 6.68560358851e-07 | 1.0 | LSM2 LSM6 LSM3 LSM8 | spliceosomal tri-snRNP complex |
| GO:0046540 | 6.68560358851e-07 | 1.0 | LSM2 LSM6 LSM3 LSM8 | U4/U6 x U5 tri-snRNP complex |
| REAC:R-HSA-72163 | 3.66683425084e-06 | 1.0 | LSM2 LSM6 LSM3 LSM8 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 4.37825325788e-06 | 1.0 | LSM2 LSM6 LSM3 LSM8 | mRNA Splicing |
| GO:0071005 | 5.61829777936e-06 | 1.0 | LSM2 LSM6 LSM3 LSM8 | U2-type precatalytic spliceosome |
| GO:0071011 | 6.09645078186e-06 | 1.0 | LSM2 LSM6 LSM3 LSM8 | precatalytic spliceosome |
| GO:0097525 | 9.63649068965e-06 | 1.0 | LSM2 LSM6 LSM3 LSM8 | spliceosomal snRNP complex |
| REAC:R-HSA-72203 | 1.12324610099e-05 | 1.0 | LSM2 LSM6 LSM3 LSM8 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0030532 | 1.45315820527e-05 | 1.0 | LSM2 LSM6 LSM3 LSM8 | small nuclear ribonucleoprotein complex |
| GO:0120114 | 2.80701671762e-05 | 1.0 | LSM2 LSM6 LSM3 LSM8 | Sm-like protein family complex |
| REAC:R-HSA-429914 | 3.73348809378e-05 | 0.75 | LSM6 LSM3 LSM2 | Deadenylation-dependent mRNA decay |
| GO:0005684 | 6.52012849586e-05 | 1.0 | LSM2 LSM6 LSM3 LSM8 | U2-type spliceosomal complex |
| CORUM:351 | 0.000300134552669 | 0.75 | LSM6 LSM3 LSM2 | Spliceosome |
| CORUM:5613 | 0.000602576435264 | 0.5 | LSM2 LSM8 | Emerin complex 25 |
| GO:0005681 | 0.000657808747052 | 1.0 | LSM2 LSM6 LSM3 LSM8 | spliceosomal complex |
| REAC:R-HSA-8953854 | 0.000676603019954 | 1.0 | LSM2 LSM6 LSM3 LSM8 | Metabolism of RNA |
| GO:0043928 | 0.00197902980402 | 0.75 | LSM6 LSM3 LSM2 | exonucleolytic catabolism of deadenylated mRNA |
| GO:0000291 | 0.00237379826551 | 0.75 | LSM6 LSM3 LSM2 | nuclear-transcribed mRNA catabolic process, exonucleolytic |
| GO:0000377 | 0.00944788787297 | 1.0 | LSM2 LSM6 LSM3 LSM8 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000398 | 0.00944788787297 | 1.0 | LSM2 LSM6 LSM3 LSM8 | mRNA splicing, via spliceosome |
| GO:0000375 | 0.00981835447646 | 1.0 | LSM2 LSM6 LSM3 LSM8 | RNA splicing, via transesterification reactions |
| CORUM:1181 | 0.0149958507614 | 0.5 | LSM2 LSM3 | C complex spliceosome |
| GO:0000932 | 0.0158182712902 | 0.75 | LSM6 LSM3 LSM2 | P-body |
| GO:0008380 | 0.0187431053955 | 1.0 | LSM2 LSM6 LSM3 LSM8 | RNA splicing |
| GO:0000288 | 0.0198185309013 | 0.75 | LSM6 LSM3 LSM2 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| GO:0006397 | 0.0251226492241 | 1.0 | LSM2 LSM6 LSM3 LSM8 | mRNA processing |
| GO:1990726 | 0.0270421395626 | 0.5 | LSM2 LSM3 | Lsm1-7-Pat1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LSM8 | LSM2 | 1.0 | 0.949 | youn (LSM2) bioplex_WMM Guru boldt youn_WMM fraction boldt_WMM |
| LSM6 | LSM3 | 1.0 | 0.949 | bioplex (LSM6) bioplex_WMM Guru youn_WMM Malo fraction boldt_WMM |
| LSM8 | LSM3 | 1.0 | 0.949 | bioplex_WMM Guru youn_WMM Malo fraction boldt_WMM |
| LSM2 | LSM6 | 1.0 | 0.949 | youn (LSM2) bioplex (LSM6) bioplex_WMM Guru boldt youn_WMM fraction boldt_WMM |
| LSM8 | LSM6 | 1.0 | 0.949 | bioplex (LSM6) bioplex_WMM Guru boldt youn_WMM Malo fraction boldt_WMM |
| LSM2 | LSM3 | 1.0 | 0.949 | youn (LSM2) bioplex_WMM Guru youn_WMM gupta_WMM fraction boldt_WMM |
Images
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Complex HuMAP2_05468 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes