hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05472
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PHF20 | PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP) | UniProt NCBI |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) | UniProt NCBI |
| KANSL2 | KAT8 regulatory NSL complex subunit 2 (NSL complex protein NSL2) (Non-specific lethal 2 homolog) | UniProt NCBI |
| MCRS1 | Microspherule protein 1 (58 kDa microspherule protein) (Cell cycle-regulated factor p78) (INO80 complex subunit J) (MCRS2) | UniProt NCBI |
| DUS2 | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (EC 1.3.1.91) (Dihydrouridine synthase 2) (Up-regulated in lung cancer protein 8) (URLC8) (tRNA-dihydrouridine synthase 2-like) (hDUS2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7221 | 2.28646948215e-11 | 0.8 | KANSL2 KANSL1 MCRS1 PHF20 | NSL complex |
| GO:0043995 | 2.56070819562e-08 | 0.8 | KANSL2 KANSL1 MCRS1 PHF20 | histone acetyltransferase activity (H4-K5 specific) |
| GO:0043996 | 2.56070819562e-08 | 0.8 | KANSL2 KANSL1 MCRS1 PHF20 | histone acetyltransferase activity (H4-K8 specific) |
| GO:0046972 | 2.56070819562e-08 | 0.8 | KANSL2 KANSL1 MCRS1 PHF20 | histone acetyltransferase activity (H4-K16 specific) |
| GO:0043982 | 1.66401304789e-07 | 0.8 | KANSL2 KANSL1 MCRS1 PHF20 | histone H4-K8 acetylation |
| GO:0043981 | 1.66401304789e-07 | 0.8 | KANSL2 KANSL1 MCRS1 PHF20 | histone H4-K5 acetylation |
| GO:0010485 | 2.90104413489e-07 | 0.8 | KANSL2 KANSL1 MCRS1 PHF20 | H4 histone acetyltransferase activity |
| GO:0043984 | 2.90104413489e-07 | 0.8 | KANSL2 KANSL1 MCRS1 PHF20 | histone H4-K16 acetylation |
| CORUM:5386 | 3.94348985886e-06 | 0.6 | KANSL1 MCRS1 PHF20 | MLL1-WDR5 complex |
| REAC:R-HSA-3214847 | 5.88493116331e-06 | 0.8 | KANSL2 KANSL1 MCRS1 PHF20 | HATs acetylate histones |
| GO:0044545 | 9.08002798436e-06 | 0.6 | KANSL2 MCRS1 KANSL1 | NSL complex |
| GO:0043967 | 3.56241182538e-05 | 0.8 | KANSL2 KANSL1 MCRS1 PHF20 | histone H4 acetylation |
| GO:0004402 | 4.46760620155e-05 | 0.8 | KANSL2 KANSL1 MCRS1 PHF20 | histone acetyltransferase activity |
| GO:0061733 | 5.1601378618e-05 | 0.8 | KANSL2 KANSL1 MCRS1 PHF20 | peptide-lysine-N-acetyltransferase activity |
| REAC:R-HSA-4839726 | 7.68024844941e-05 | 0.8 | KANSL2 KANSL1 MCRS1 PHF20 | Chromatin organization |
| REAC:R-HSA-3247509 | 7.68024844941e-05 | 0.8 | KANSL2 KANSL1 MCRS1 PHF20 | Chromatin modifying enzymes |
| GO:0034212 | 9.31770903001e-05 | 0.8 | KANSL2 KANSL1 MCRS1 PHF20 | peptide N-acetyltransferase activity |
| GO:0008080 | 0.000164422098058 | 0.8 | KANSL2 KANSL1 MCRS1 PHF20 | N-acetyltransferase activity |
| GO:0000123 | 0.000173300430897 | 0.8 | KANSL2 KANSL1 MCRS1 PHF20 | histone acetyltransferase complex |
| GO:0031248 | 0.000283155128059 | 0.8 | KANSL2 KANSL1 MCRS1 PHF20 | protein acetyltransferase complex |
| GO:1902493 | 0.000283155128059 | 0.8 | KANSL2 KANSL1 MCRS1 PHF20 | acetyltransferase complex |
| GO:0016410 | 0.000310236355112 | 0.8 | KANSL2 KANSL1 MCRS1 PHF20 | N-acyltransferase activity |
| GO:0016407 | 0.000403202499238 | 0.8 | KANSL2 KANSL1 MCRS1 PHF20 | acetyltransferase activity |
| GO:0016573 | 0.000625996400903 | 0.8 | KANSL2 KANSL1 MCRS1 PHF20 | histone acetylation |
| GO:0018393 | 0.000674764960334 | 0.8 | KANSL2 KANSL1 MCRS1 PHF20 | internal peptidyl-lysine acetylation |
| GO:0006475 | 0.000809132371969 | 0.8 | KANSL2 KANSL1 MCRS1 PHF20 | internal protein amino acid acetylation |
| GO:0018394 | 0.000838244988417 | 0.8 | KANSL2 KANSL1 MCRS1 PHF20 | peptidyl-lysine acetylation |
| GO:0006473 | 0.0022600637582 | 0.8 | KANSL2 KANSL1 MCRS1 PHF20 | protein acetylation |
| GO:0071339 | 0.00265002518516 | 0.6 | KANSL1 MCRS1 PHF20 | MLL1 complex |
| GO:0044665 | 0.00265002518516 | 0.6 | KANSL1 MCRS1 PHF20 | MLL1/2 complex |
| GO:0043543 | 0.00534283459488 | 0.8 | KANSL2 KANSL1 MCRS1 PHF20 | protein acylation |
| GO:0016747 | 0.00558300460276 | 0.8 | KANSL2 KANSL1 MCRS1 PHF20 | transferase activity, transferring acyl groups other than amino-acyl groups |
| GO:0016746 | 0.00896454920435 | 0.8 | KANSL2 KANSL1 MCRS1 PHF20 | transferase activity, transferring acyl groups |
| GO:1902562 | 0.00964423896068 | 0.6 | KANSL2 MCRS1 KANSL1 | H4 histone acetyltransferase complex |
| GO:0018205 | 0.0327910140884 | 0.8 | KANSL2 KANSL1 MCRS1 PHF20 | peptidyl-lysine modification |
| CORUM:6314 | 0.0499494897235 | 0.2 | MCRS1 | MSP58-RINT1 complex |
| CORUM:1057 | 0.0499494897235 | 0.2 | MCRS1 | DIPA-MCRS1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PHF20 | KANSL1 | 0.51 | 0.63 | bioplex (KANSL1,PHF20) bioplex_WMM |
| DUS2 | KANSL1 | 0.197 | 0.45 | bioplex (KANSL1) bioplex_WMM |
| KANSL2 | KANSL1 | 0.09 | 0.355 | bioplex (KANSL1) bioplex_WMM |
| MCRS1 | KANSL1 | 0.055 | 0.311 | hein_WMM bioplex (KANSL1) bioplex_WMM |
| KANSL2 | PHF20 | 0.038 | 0.263 | bioplex (PHF20) bioplex_WMM |
| PHF20 | MCRS1 | 0.02 | 0.185 | bioplex (PHF20) bioplex_WMM |
| KANSL2 | MCRS1 | 0.013 | 0.143 | bioplex_WMM Guru fraction boldt_WMM |
| PHF20 | DUS2 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| KANSL2 | DUS2 | 0.008 | 0.066 | bioplex_WMM WMM_only |
| MCRS1 | DUS2 | 0.008 | 0.02 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05472 has an average edge precision of 0.251 which is ranked 5358 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PHF20 | HuMAP2_00495 HuMAP2_04164 HuMAP2_04368 HuMAP2_05472 |
| KANSL1 | HuMAP2_00495 HuMAP2_04164 HuMAP2_05472 |
| KANSL2 | HuMAP2_00495 HuMAP2_05472 |
| MCRS1 | HuMAP2_00495 HuMAP2_05472 |
| DUS2 | HuMAP2_00495 HuMAP2_05472 |