hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05479
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RAPGEF5 | Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF) (Related to Epac) (Repac) | UniProt NCBI |
| CHL1 | Neural cell adhesion molecule L1-like protein (Close homolog of L1) [Cleaved into: Processed neural cell adhesion molecule L1-like protein] | UniProt NCBI |
| ANK2 | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | UniProt NCBI |
| ANK3 | Ankyrin-3 (ANK-3) (Ankyrin-G) | UniProt NCBI |
| FPGS | Folylpolyglutamate synthase, mitochondrial (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolylpolyglutamate synthase) (Tetrahydrofolate synthase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-373760 | 0.000596598643168 | 0.6 | ANK3 ANK2 CHL1 | L1CAM interactions |
| WP:WP4148 | 0.00259148909572 | 0.4 | ANK3 CHL1 | Splicing factor NOVA regulated synaptic proteins |
| REAC:R-HSA-445095 | 0.00546022370076 | 0.4 | ANK3 ANK2 | Interaction between L1 and Ankyrins |
| CORUM:6618 | 0.0499494897235 | 0.2 | ANK3 | RhBG-kAE1-ankyrin-G complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| 114299 | ANK3 | 0.996 | 0.927 | bioplex (114299) bioplex_WMM youn_WMM gupta_WMM |
| 114299 | FPGS | 0.927 | 0.844 | bioplex (114299) bioplex_WMM |
| ANK3 | RAPGEF5 | 0.602 | 0.67 | bioplex (RAPGEF5) bioplex_WMM |
| 114299 | ANK2 | 0.5 | 0.621 | bioplex (114299) bioplex_WMM |
| RAPGEF5 | ANK2 | 0.091 | 0.355 | bioplex (RAPGEF5) bioplex_WMM |
| ANK3 | CHL1 | 0.047 | 0.29 | bioplex (CHL1) bioplex_WMM |
| ANK2 | CHL1 | 0.03 | 0.236 | bioplex (CHL1) bioplex_WMM |
| ANK3 | ANK2 | 0.012 | 0.15 | bioplex_WMM youn_WMM WMM_only |
| ANK3 | FPGS | 0.008 | 0.013 | bioplex_WMM WMM_only |
| ANK2 | FPGS | 0.007 | 0.011 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05479 has an average edge precision of 0.412 which is ranked 3177 out of all 6965 complexes.
Related Complexes