hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_05494
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CAMK2G | Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) | UniProt NCBI |
| CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | UniProt NCBI |
| CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) | UniProt NCBI |
| CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-111932 | 1.14269172132e-11 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | CaMK IV-mediated phosphorylation of CREB |
| GO:0005954 | 2.4395561352e-11 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | calcium- and calmodulin-dependent protein kinase complex |
| REAC:R-HSA-442982 | 2.77510846606e-10 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Ras activation upon Ca2+ influx through NMDA receptor |
| REAC:R-HSA-438066 | 3.51513739035e-10 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Unblocking of NMDA receptors, glutamate binding and activation |
| REAC:R-HSA-9617324 | 3.51513739035e-10 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Negative regulation of NMDA receptor-mediated neuronal transmission |
| REAC:R-HSA-9620244 | 4.39392173793e-10 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Long-term potentiation |
| REAC:R-HSA-3371571 | 8.03058348594e-10 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | HSF1-dependent transactivation |
| REAC:R-HSA-399719 | 1.35581279633e-09 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Trafficking of AMPA receptors |
| REAC:R-HSA-399721 | 1.35581279633e-09 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Glutamate binding, activation of AMPA receptors and synaptic plasticity |
| REAC:R-HSA-442742 | 1.35581279633e-09 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling |
| WP:WP4008 | 1.86997281146e-09 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | NO/cGMP/PKG mediated Neuroprotection |
| REAC:R-HSA-9022692 | 2.15397389469e-09 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Regulation of MECP2 expression and activity |
| REAC:R-HSA-5673000 | 2.15397389469e-09 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | RAF activation |
| REAC:R-HSA-111933 | 3.71102739972e-09 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Calmodulin induced events |
| REAC:R-HSA-111997 | 3.71102739972e-09 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | CaM pathway |
| REAC:R-HSA-111996 | 4.74851893082e-09 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Ca-dependent events |
| REAC:R-HSA-5576892 | 5.98960910592e-09 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Phase 0 - rapid depolarisation |
| REAC:R-HSA-9609736 | 6.69426900073e-09 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Assembly and cell surface presentation of NMDA receptors |
| REAC:R-HSA-1489509 | 7.4593283151e-09 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | DAG and IP3 signaling |
| WP:WP4341 | 9.02582736195e-09 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Non-genomic actions of 1,25 dihydroxyvitamin D3 |
| KEGG:04971 | 9.43033012544e-09 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Gastric acid secretion |
| KEGG:05031 | 1.00806977203e-08 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Amphetamine addiction |
| KEGG:04720 | 1.00806977203e-08 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Long-term potentiation |
| REAC:R-HSA-6802955 | 1.23112336398e-08 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| REAC:R-HSA-6802946 | 1.23112336398e-08 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Signaling by moderate kinase activity BRAF mutants |
| REAC:R-HSA-5578775 | 1.35123296046e-08 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Ion homeostasis |
| KEGG:05214 | 1.47165772086e-08 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Glioma |
| REAC:R-HSA-936837 | 1.61758895931e-08 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Ion transport by P-type ATPases |
| KEGG:04911 | 1.8591044121e-08 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Insulin secretion |
| REAC:R-HSA-112043 | 2.26633858062e-08 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | PLC beta mediated events |
| REAC:R-HSA-112040 | 2.455200129e-08 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | G-protein mediated events |
| REAC:R-HSA-8986944 | 2.65562462933e-08 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Transcriptional Regulation by MECP2 |
| KEGG:04012 | 2.71513743162e-08 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | ErbB signaling pathway |
| KEGG:04750 | 3.00650898102e-08 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Inflammatory mediator regulation of TRP channels |
| KEGG:04912 | 3.00650898102e-08 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | GnRH signaling pathway |
| WP:WP673 | 3.06806004299e-08 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | ErbB Signaling Pathway |
| REAC:R-HSA-6802949 | 3.33094636765e-08 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Signaling by RAS mutants |
| KEGG:04713 | 4.21390856008e-08 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Circadian entrainment |
| KEGG:04925 | 4.21390856008e-08 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Aldosterone synthesis and secretion |
| KEGG:04916 | 4.41221013938e-08 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Melanogenesis |
| REAC:R-HSA-6802952 | 5.40207511254e-08 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Signaling by BRAF and RAF fusions |
| KEGG:04922 | 6.00304288806e-08 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Glucagon signaling pathway |
| KEGG:04725 | 6.00304288806e-08 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Cholinergic synapse |
| KEGG:04066 | 7.08596185648e-08 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | HIF-1 signaling pathway |
| WP:WP428 | 7.81962595458e-08 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Wnt Signaling |
| KEGG:04722 | 9.32562799027e-08 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Neurotrophin signaling pathway |
| KEGG:04114 | 9.32562799027e-08 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Oocyte meiosis |
| REAC:R-HSA-438064 | 9.870951986e-08 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Post NMDA receptor activation events |
| REAC:R-HSA-877300 | 1.10228940689e-07 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Interferon gamma signaling |
| WP:WP536 | 1.24471457401e-07 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Calcium Regulation in the Cardiac Cell |
| REAC:R-HSA-6802957 | 1.29362225284e-07 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Oncogenic MAPK signaling |
| KEGG:04728 | 1.53518737678e-07 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Dopaminergic synapse |
| KEGG:04740 | 1.69526580984e-07 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Olfactory transduction |
| REAC:R-HSA-442755 | 1.74986096744e-07 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Activation of NMDA receptors and postsynaptic events |
| WP:WP289 | 1.77536652149e-07 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Myometrial Relaxation and Contraction Pathways |
| REAC:R-HSA-3371556 | 1.83627385472e-07 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Cellular response to heat stress |
| REAC:R-HSA-111885 | 1.9258481891e-07 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Opioid Signalling |
| KEGG:04261 | 1.98948079745e-07 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Adrenergic signaling in cardiomyocytes |
| KEGG:04921 | 2.39127731928e-07 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Oxytocin signaling pathway |
| KEGG:04934 | 2.8510631747e-07 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Cushing syndrome |
| GO:0004683 | 3.08603851103e-07 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | calmodulin-dependent protein kinase activity |
| KEGG:04310 | 3.3741663543e-07 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Wnt signaling pathway |
| KEGG:05152 | 3.66119097608e-07 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Tuberculosis |
| KEGG:04217 | 3.86245887493e-07 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Necroptosis |
| KEGG:04020 | 4.63280763538e-07 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Calcium signaling pathway |
| REAC:R-HSA-5576891 | 5.04530227089e-07 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Cardiac conduction |
| KEGG:04360 | 5.38017270501e-07 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Axon guidance |
| KEGG:04024 | 6.0691404027e-07 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | cAMP signaling pathway |
| KEGG:05205 | 9.10856441722e-07 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Proteoglycans in cancer |
| REAC:R-HSA-983712 | 2.38463075313e-06 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Ion channel transport |
| REAC:R-HSA-397014 | 3.19306292696e-06 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Muscle contraction |
| REAC:R-HSA-913531 | 3.34554751922e-06 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Interferon Signaling |
| REAC:R-HSA-112314 | 3.42380594072e-06 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-5673001 | 5.1884893429e-06 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | RAF/MAP kinase cascade |
| REAC:R-HSA-5684996 | 5.74894108903e-06 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | MAPK1/MAPK3 signaling |
| REAC:R-HSA-9607240 | 7.27878120934e-06 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | FLT3 Signaling |
| REAC:R-HSA-449836 | 9.77039511453e-06 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Other interleukin signaling |
| REAC:R-HSA-112315 | 9.77039511453e-06 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Transmission across Chemical Synapses |
| REAC:R-HSA-5683057 | 1.14261241307e-05 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | MAPK family signaling cascades |
| REAC:R-HSA-418594 | 1.71348623322e-05 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | G alpha (i) signalling events |
| REAC:R-HSA-9006925 | 1.76692529985e-05 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Intracellular signaling by second messengers |
| GO:0060333 | 2.50979095633e-05 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | interferon-gamma-mediated signaling pathway |
| GO:1900034 | 3.12988953256e-05 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | regulation of cellular response to heat |
| KEGG:05200 | 3.47503918145e-05 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Pathways in cancer |
| GO:0005516 | 4.70712600242e-05 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | calmodulin binding |
| REAC:R-HSA-5663202 | 4.78748852749e-05 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Diseases of signal transduction |
| REAC:R-HSA-112316 | 5.01992222621e-05 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Neuronal System |
| REAC:R-HSA-2262752 | 0.00010216546718 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Cellular responses to stress |
| GO:0034605 | 0.000107859485517 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | cellular response to heat |
| GO:0071346 | 0.000116616394242 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | cellular response to interferon-gamma |
| GO:0030666 | 0.0001570766767 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | endocytic vesicle membrane |
| GO:0034341 | 0.000174678196193 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | response to interferon-gamma |
| GO:0009408 | 0.000180861495173 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | response to heat |
| REAC:R-HSA-442729 | 0.000211071833435 | 0.5 | CAMK2G CAMK2B | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde |
| REAC:R-HSA-8953897 | 0.00021167720149 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Cellular responses to external stimuli |
| REAC:R-HSA-449147 | 0.000252642799005 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Signaling by Interleukins |
| REAC:R-HSA-388396 | 0.000313056285005 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | GPCR downstream signalling |
| GO:0051924 | 0.000313257328826 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | regulation of calcium ion transport |
| GO:0009266 | 0.000373974563235 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | response to temperature stimulus |
| REAC:R-HSA-372790 | 0.000435038620452 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Signaling by GPCR |
| REAC:R-HSA-382551 | 0.000491356075286 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Transport of small molecules |
| REAC:R-HSA-1280215 | 0.000849103795306 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Cytokine Signaling in Immune system |
| GO:0030139 | 0.00207257982907 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | endocytic vesicle |
| GO:0010959 | 0.00211187044194 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | regulation of metal ion transport |
| GO:0043502 | 0.00281780772825 | 0.75 | CAMK2G CAMK2D CAMK2B | regulation of muscle adaptation |
| REAC:R-HSA-1643685 | 0.00304553054305 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Disease |
| GO:0006816 | 0.00406662724791 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | calcium ion transport |
| REAC:R-HSA-212436 | 0.00429443977897 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Generic Transcription Pathway |
| GO:0043500 | 0.00587743889796 | 0.75 | CAMK2G CAMK2D CAMK2B | muscle adaptation |
| GO:0072511 | 0.00602750285099 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | divalent inorganic cation transport |
| GO:0070838 | 0.00602750285099 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | divalent metal ion transport |
| REAC:R-HSA-73857 | 0.00664358115488 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | RNA Polymerase II Transcription |
| GO:0010663 | 0.00811409485621 | 0.5 | CAMK2A CAMK2D | positive regulation of striated muscle cell apoptotic process |
| GO:0010666 | 0.00811409485621 | 0.5 | CAMK2A CAMK2D | positive regulation of cardiac muscle cell apoptotic process |
| REAC:R-HSA-74160 | 0.0102868657133 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Gene expression (Transcription) |
| WP:WP4549 | 0.0109018647515 | 0.5 | CAMK2A CAMK2B | Fragile X Syndrome |
| GO:0043269 | 0.011836710023 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | regulation of ion transport |
| GO:0004674 | 0.0181401540934 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | protein serine/threonine kinase activity |
| GO:0014733 | 0.0270421395626 | 0.5 | CAMK2G CAMK2B | regulation of skeletal muscle adaptation |
| REAC:R-HSA-168256 | 0.0358063812597 | 1.0 | CAMK2B CAMK2G CAMK2D CAMK2A | Immune System |
| CORUM:5655 | 0.0499140284799 | 0.25 | CAMK2A | Ternary complex (LRRC7, CAMK2a, ACTN4) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CAMK2G | CAMK2D | 1.0 | 0.949 | bioplex (CAMK2D) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| CAMK2D | CAMK2A | 0.996 | 0.928 | bioplex (CAMK2D) bioplex_WMM boldt (CAMK2A) boldt_WMM |
| CAMK2B | CAMK2D | 0.988 | 0.901 | bioplex (CAMK2D) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| CAMK2B | CAMK2A | 0.022 | 0.207 | bioplex_WMM boldt (CAMK2A) boldt_WMM |
| CAMK2G | CAMK2B | 0.01 | 0.14 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| CAMK2G | CAMK2A | 0.009 | 0.098 | bioplex_WMM boldt (CAMK2A) boldt_WMM |
Images
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Complex HuMAP2_05494 has an average edge precision of 0.537 which is ranked 2293 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CAMK2G | HuMAP2_00728 HuMAP2_02476 HuMAP2_05494 HuMAP2_05617 |
| CAMK2B | HuMAP2_00728 HuMAP2_02476 HuMAP2_05494 HuMAP2_05645 |
| CAMK2A | HuMAP2_00728 HuMAP2_02476 HuMAP2_05494 HuMAP2_05645 |
| CAMK2D | HuMAP2_00728 HuMAP2_02476 HuMAP2_05494 |