hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05496
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RAPGEF5 | Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF) (Related to Epac) (Repac) | UniProt NCBI |
| CHL1 | Neural cell adhesion molecule L1-like protein (Close homolog of L1) [Cleaved into: Processed neural cell adhesion molecule L1-like protein] | UniProt NCBI |
| ANK2 | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | UniProt NCBI |
| ANK1 | Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-447041 | 0.000281403908969 | 0.5 | CHL1 ANK1 | CHL1 interactions |
| REAC:R-HSA-373760 | 0.000297923324705 | 0.75 | ANK2 CHL1 ANK1 | L1CAM interactions |
| REAC:R-HSA-445095 | 0.00407268683926 | 0.5 | ANK2 ANK1 | Interaction between L1 and Ankyrins |
| REAC:R-HSA-422475 | 0.0294332368862 | 0.75 | ANK2 CHL1 ANK1 | Axon guidance |
| KEGG:05205 | 0.03463652866 | 0.5 | ANK2 ANK1 | Proteoglycans in cancer |
| REAC:R-HSA-6807878 | 0.0464213162589 | 0.5 | ANK2 ANK1 | COPI-mediated anterograde transport |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RAPGEF5 | ANK1 | 0.254 | 0.478 | bioplex (RAPGEF5) bioplex_WMM |
| RAPGEF5 | ANK2 | 0.091 | 0.355 | bioplex (RAPGEF5) bioplex_WMM |
| ANK2 | CHL1 | 0.03 | 0.236 | bioplex (CHL1) bioplex_WMM |
| ANK1 | CHL1 | 0.027 | 0.225 | bioplex (CHL1) bioplex_WMM |
| ANK2 | ANK1 | 0.008 | 0.088 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05496 has an average edge precision of 0.276 which is ranked 4935 out of all 6965 complexes.
Related Complexes