hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05504
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HTRA2 | Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI) | UniProt NCBI |
| CASP9 | Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10] | UniProt NCBI |
| BIRC8 | Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis-like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04215 | 6.3465431699e-05 | 1.0 | HTRA2 CASP9 | Apoptosis - multiple species |
| WP:WP2507 | 6.37114077238e-05 | 1.0 | HTRA2 CASP9 | Nanomaterial induced apoptosis |
| WP:WP2371 | 0.000234726238982 | 1.0 | HTRA2 CASP9 | Parkinsons Disease Pathway |
| KEGG:04210 | 0.00113070596705 | 1.0 | HTRA2 CASP9 | Apoptosis |
| KEGG:05012 | 0.00114894316007 | 1.0 | HTRA2 CASP9 | Parkinson disease |
| WP:WP1772 | 0.00120716351477 | 1.0 | HTRA2 CASP9 | Apoptosis Modulation and Signaling |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CASP9 | BIRC8 | 0.984 | 0.899 | bioplex (112401) bioplex_WMM |
| HTRA2 | BIRC8 | 0.915 | 0.839 | bioplex (112401) bioplex_WMM |
| HTRA2 | CASP9 | 0.008 | 0.044 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05504 has an average edge precision of 0.594 which is ranked 1969 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| HTRA2 | HuMAP2_00263 HuMAP2_05376 HuMAP2_05504 HuMAP2_06026 |
| CASP9 | HuMAP2_05018 HuMAP2_05376 HuMAP2_05504 |
| BIRC8 | HuMAP2_05018 HuMAP2_05376 HuMAP2_05504 |