hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05510
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MAPK7 | Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) | UniProt NCBI |
| MAP2K5 | Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5) | UniProt NCBI |
| NLRP8 | NACHT, LRR and PYD domains-containing protein 8 (Nucleotide-binding oligomerization domain protein 16) (PYRIN and NACHT-containing protein 4) | UniProt NCBI |
| MAP3K3 | Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) | UniProt NCBI |
| TRAF7 | E3 ubiquitin-protein ligase TRAF7 (EC 2.3.2.27) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (RING-type E3 ubiquitin transferase TRAF7) (TNF receptor-associated factor 7) | UniProt NCBI |
| MAP3K2 | Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5199 | 1.25951779514e-06 | 0.5 | TRAF7 MAP3K3 MAP2K5 | Kinase maturation complex 1 |
| WP:WP3915 | 2.800656837e-06 | 0.666666666667 | MAP2K5 MAP3K2 MAP3K3 MAPK7 | Angiopoietin Like Protein 8 Regulatory Pathway |
| WP:WP481 | 6.70518465241e-06 | 0.666666666667 | MAP2K5 MAP3K2 MAP3K3 MAPK7 | Insulin Signaling |
| WP:WP437 | 7.8193322942e-06 | 0.666666666667 | MAP2K5 MAP3K2 MAP3K3 MAPK7 | EGF/EGFR Signaling Pathway |
| REAC:R-HSA-198765 | 2.21716431826e-05 | 0.333333333333 | MAPK7 MAP2K5 | Signalling to ERK5 |
| KEGG:04010 | 5.76320574246e-05 | 0.666666666667 | MAP2K5 MAP3K2 MAP3K3 MAPK7 | MAPK signaling pathway |
| KEGG:04912 | 0.000141809175237 | 0.5 | MAP3K2 MAP3K3 MAPK7 | GnRH signaling pathway |
| KEGG:04540 | 0.000158298174337 | 0.5 | MAP3K2 MAPK7 MAP2K5 | Gap junction |
| KEGG:04722 | 0.000328600438861 | 0.5 | MAP2K5 MAP3K3 MAPK7 | Neurotrophin signaling pathway |
| WP:WP2380 | 0.000603242681284 | 0.5 | MAP3K2 MAPK7 MAP2K5 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| WP:WP382 | 0.00250833969364 | 0.5 | MAP3K2 MAPK7 MAP2K5 | MAPK Signaling Pathway |
| WP:WP422 | 0.00293450086565 | 0.333333333333 | MAP3K3 MAP3K2 | MAPK Cascade |
| WP:WP2795 | 0.00625232518217 | 0.333333333333 | MAPK7 MAP2K5 | Cardiac Hypertrophic Response |
| WP:WP195 | 0.0070633221054 | 0.333333333333 | MAP3K3 MAP3K2 | IL-1 signaling pathway |
| WP:WP1544 | 0.0157179535721 | 0.333333333333 | MAPK7 MAP2K5 | MicroRNAs in cardiomyocyte hypertrophy |
| WP:WP185 | 0.0235215924424 | 0.333333333333 | MAPK7 MAP2K5 | Integrin-mediated Cell Adhesion |
| WP:WP3931 | 0.0261098195507 | 0.333333333333 | MAPK7 MAP2K5 | ESC Pluripotency Pathways |
| GO:0032147 | 0.0371455172523 | 0.666666666667 | TRAF7 MAP3K2 MAP3K3 MAP2K5 | activation of protein kinase activity |
| KEGG:05418 | 0.0474671394747 | 0.333333333333 | MAPK7 MAP2K5 | Fluid shear stress and atherosclerosis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MAP3K2 | MAP2K5 | 0.999 | 0.949 | bioplex (MAP2K5) bioplex_WMM |
| MAP2K5 | MAPK7 | 0.993 | 0.918 | bioplex (MAP2K5) bioplex_WMM |
| MAP3K3 | MAP2K5 | 0.089 | 0.355 | bioplex (MAP2K5) bioplex_WMM |
| MAP3K2 | TRAF7 | 0.028 | 0.231 | hein_WMM bioplex_WMM hein (MAP3K2) |
| MAP3K2 | NLRP8 | 0.026 | 0.22 | fraction |
| MAP3K3 | MAP3K2 | 0.02 | 0.187 | hein_WMM bioplex_WMM boldt hein (MAP3K2) boldt_WMM |
| MAP3K3 | MAPK7 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| MAP3K2 | MAPK7 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| MAP3K3 | TRAF7 | 0.008 | 0.085 | hein_WMM bioplex_WMM WMM_only |
| MAPK7 | TRAF7 | 0.008 | 0.014 | bioplex_WMM gupta_WMM WMM_only |
| MAP2K5 | TRAF7 | 0.004 | 0.011 | bioplex (MAP2K5) bioplex_WMM |
Images
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Complex HuMAP2_05510 has an average edge precision of 0.287 which is ranked 4784 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MAPK7 | HuMAP2_01089 HuMAP2_02532 HuMAP2_05510 HuMAP2_06470 |
| MAP2K5 | HuMAP2_01089 HuMAP2_02532 HuMAP2_05510 HuMAP2_06470 |
| NLRP8 | HuMAP2_01089 HuMAP2_05510 |
| MAP3K3 | HuMAP2_01089 HuMAP2_05510 HuMAP2_06470 |
| TRAF7 | HuMAP2_03832 HuMAP2_04792 HuMAP2_05510 |
| MAP3K2 | HuMAP2_01089 HuMAP2_02532 HuMAP2_05510 HuMAP2_06470 |