hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05526
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GFM1 | Elongation factor G, mitochondrial (EF-Gmt) (Elongation factor G 1, mitochondrial) (mEF-G 1) (Elongation factor G1) (hEFG1) | UniProt NCBI |
| S100A10 | Protein S100-A10 (Calpactin I light chain) (Calpactin-1 light chain) (Cellular ligand of annexin II) (S100 calcium-binding protein A10) (p10 protein) (p11) | UniProt NCBI |
| PRDX1 | Peroxiredoxin-1 (EC 1.11.1.15) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) | UniProt NCBI |
| MCCC2 | Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCase subunit beta) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 2) (3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta) | UniProt NCBI |
| MCCC1 | Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCase subunit alpha) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (3-methylcrotonyl-CoA carboxylase biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0001942 | 2.78658791667e-06 | 0.8 | MCCC2 MCCC1 PRDX1 GFM1 | Metabolic acidosis |
| CORUM:7190 | 6.70868171695e-06 | 0.4 | MCCC2 MCCC1 | 3-methylcrotonyl-CoA carboxylase |
| HP:0004357 | 4.64766403483e-05 | 0.4 | MCCC2 MCCC1 | Abnormal circulating leucine concentration |
| HP:0008281 | 0.000278784943944 | 0.4 | MCCC2 MCCC1 | Acute hyperammonemia |
| REAC:R-HSA-3371599 | 0.000283261545489 | 0.4 | MCCC2 MCCC1 | Defective HLCS causes multiple carboxylase deficiency |
| HP:0001941 | 0.000333341880049 | 0.8 | MCCC2 MCCC1 PRDX1 GFM1 | Acidosis |
| HP:0001992 | 0.000369560169821 | 0.6 | MCCC2 PRDX1 MCCC1 | Organic aciduria |
| REAC:R-HSA-3323169 | 0.000377631329325 | 0.4 | MCCC2 MCCC1 | Defects in biotin (Btn) metabolism |
| HP:0004360 | 0.000472831071609 | 0.8 | MCCC2 MCCC1 PRDX1 GFM1 | Abnormality of acid-base homeostasis |
| REAC:R-HSA-196780 | 0.000741476933235 | 0.4 | MCCC2 MCCC1 | Biotin transport and metabolism |
| HP:0010892 | 0.00097535418756 | 0.4 | MCCC2 MCCC1 | Abnormal circulating branched chain amino acid concentration |
| HP:0003112 | 0.00141044232307 | 0.6 | MCCC2 PRDX1 MCCC1 | Abnormality of serum amino acid level |
| REAC:R-HSA-70895 | 0.00230284247734 | 0.4 | MCCC2 MCCC1 | Branched-chain amino acid catabolism |
| HP:0004354 | 0.00234614920866 | 0.6 | MCCC2 PRDX1 MCCC1 | Abnormal circulating carboxylic acid concentration |
| REAC:R-HSA-3296482 | 0.00282729215335 | 0.4 | MCCC2 MCCC1 | Defects in vitamin and cofactor metabolism |
| HP:0001254 | 0.00354196137083 | 0.6 | MCCC2 PRDX1 MCCC1 | Lethargy |
| GO:0004485 | 0.00450823411379 | 0.4 | MCCC2 MCCC1 | methylcrotonoyl-CoA carboxylase activity |
| GO:1905202 | 0.00450823411379 | 0.4 | MCCC2 MCCC1 | methylcrotonoyl-CoA carboxylase complex |
| GO:0002169 | 0.00450823411379 | 0.4 | MCCC2 MCCC1 | 3-methylcrotonyl-CoA carboxylase complex, mitochondrial |
| KEGG:00280 | 0.00461334650691 | 0.4 | MCCC2 MCCC1 | Valine, leucine and isoleucine degradation |
| HP:0012072 | 0.00727567741272 | 0.6 | MCCC2 PRDX1 MCCC1 | Aciduria |
| HP:0002919 | 0.00792937512816 | 0.4 | MCCC2 MCCC1 | Ketonuria |
| HP:0011968 | 0.0113397146668 | 0.8 | MCCC2 MCCC1 PRDX1 GFM1 | Feeding difficulties |
| HP:0002179 | 0.0188011826397 | 0.4 | MCCC2 MCCC1 | Opisthotonus |
| CORUM:3151 | 0.0249780992026 | 0.2 | PRDX1 | Sulphiredoxin-peroxiredoxin complex |
| HP:0004372 | 0.0295629530581 | 0.6 | MCCC2 PRDX1 MCCC1 | Reduced consciousness/confusion |
| GO:0006552 | 0.0450641792523 | 0.4 | MCCC2 MCCC1 | leucine catabolic process |
| HP:0001987 | 0.0478196851342 | 0.4 | MCCC2 MCCC1 | Hyperammonemia |
| CORUM:6675 | 0.0499494897235 | 0.2 | PRDX1 | PI4K2A-PRDX1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MCCC2 | MCCC1 | 1.0 | 0.949 | bioplex_WMM Guru boldt Malo fraction boldt_WMM treiber_WMM |
| PRDX1 | MCCC2 | 0.036 | 0.264 | bioplex_WMM boldt fraction boldt_WMM |
| GFM1 | MCCC2 | 0.032 | 0.241 | bioplex_WMM fraction |
| PRDX1 | S100A10 | 0.026 | 0.224 | bioplex_WMM fraction treiber_WMM |
| GFM1 | PRDX1 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| MCCC2 | S100A10 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| MCCC1 | S100A10 | 0.007 | 0.0 | bioplex_WMM WMM_only |
| GFM1 | S100A10 | 0.006 | 0.004 | bioplex_WMM WMM_only |
| GFM1 | MCCC1 | 0.003 | 0.011 | bioplex_WMM fraction |
| PRDX1 | MCCC1 | 0.0 | 0.001 | bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_05526 has an average edge precision of 0.17 which is ranked 6530 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GFM1 | HuMAP2_00182 HuMAP2_01941 HuMAP2_04067 HuMAP2_05526 |
| S100A10 | HuMAP2_03927 HuMAP2_04702 HuMAP2_05147 HuMAP2_05526 HuMAP2_06137 |
| PRDX1 | HuMAP2_01228 HuMAP2_03283 HuMAP2_05526 HuMAP2_05584 HuMAP2_06137 |
| MCCC2 | HuMAP2_01941 HuMAP2_04067 HuMAP2_04599 HuMAP2_05526 |
| MCCC1 | HuMAP2_01941 HuMAP2_02020 HuMAP2_03882 HuMAP2_04067 HuMAP2_04599 HuMAP2_05526 |