hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05529
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PRKAA2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) | UniProt NCBI |
| PRKAA1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26) | UniProt NCBI |
| PRKAG1 | 5'-AMP-activated protein kinase subunit gamma-1 (AMPK gamma1) (AMPK subunit gamma-1) (AMPKg) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04710 | 1.09884462513e-07 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Circadian rhythm |
| WP:WP3965 | 2.11008265994e-07 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Lipid Metabolism Pathway |
| WP:WP1471 | 4.21565659625e-07 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Target Of Rapamycin (TOR) Signaling |
| KEGG:04213 | 8.33606267338e-07 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Longevity regulating pathway - multiple species |
| REAC:R-HSA-9619483 | 9.09984147875e-07 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Activation of AMPK downstream of NMDARs |
| WP:WP1541 | 9.13982690616e-07 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Energy Metabolism |
| WP:WP4539 | 1.04441362427e-06 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Synaptic signaling pathways associated with autism spectrum disorder |
| KEGG:04920 | 1.25293548061e-06 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Adipocytokine signaling pathway |
| REAC:R-HSA-380972 | 1.47287948045e-06 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Energy dependent regulation of mTOR by LKB1-AMPK |
| GO:0004679 | 1.81637152046e-06 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | AMP-activated protein kinase activity |
| KEGG:05410 | 2.56577513453e-06 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Hypertrophic cardiomyopathy (HCM) |
| KEGG:04211 | 2.66320963331e-06 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Longevity regulating pathway |
| WP:WP1403 | 2.68359230598e-06 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | AMP-activated Protein Kinase (AMPK) Signaling |
| WP:WP1982 | 2.94741704881e-06 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Sterol Regulatory Element-Binding Proteins (SREBP) signalling |
| REAC:R-HSA-165159 | 4.10886616968e-06 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | mTOR signalling |
| KEGG:04922 | 4.29674110668e-06 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Glucagon signaling pathway |
| KEGG:04931 | 5.1634269878e-06 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Insulin resistance |
| WP:WP4540 | 6.82717373445e-06 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Pathways Regulating Hippo Signaling |
| KEGG:04152 | 6.85409597589e-06 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | AMPK signaling pathway |
| KEGG:04068 | 7.23132386252e-06 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | FoxO signaling pathway |
| KEGG:04371 | 9.32616558629e-06 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Apelin signaling pathway |
| KEGG:04910 | 9.55549752694e-06 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Insulin signaling pathway |
| CORUM:6155 | 1.00675659188e-05 | 0.666666666667 | PRKAG1 PRKAA2 | PRKAA2-PRKAB2-PRKAG1 complex |
| CORUM:6154 | 1.00675659188e-05 | 0.666666666667 | PRKAG1 PRKAA1 | PRKAA1-PRKAB2-PRKAG1 complex |
| WP:WP4321 | 1.04151515907e-05 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Thermogenesis |
| KEGG:04932 | 1.15269222189e-05 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Non-alcoholic fatty liver disease (NAFLD) |
| KEGG:04921 | 1.20588724809e-05 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Oxytocin signaling pathway |
| KEGG:04530 | 1.49652172755e-05 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Tight junction |
| WP:WP3915 | 1.99751915394e-05 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Angiopoietin Like Protein 8 Regulatory Pathway |
| WP:WP4396 | 2.70021017308e-05 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Nonalcoholic fatty liver disease |
| REAC:R-HSA-438064 | 2.79631294769e-05 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Post NMDA receptor activation events |
| WP:WP3934 | 3.45203339774e-05 | 0.666666666667 | PRKAG1 PRKAA1 | Leptin and adiponectin |
| REAC:R-HSA-5628897 | 3.69388822082e-05 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | TP53 Regulates Metabolic Genes |
| REAC:R-HSA-442755 | 4.28393920683e-05 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Activation of NMDA receptors and postsynaptic events |
| KEGG:04714 | 4.51020686166e-05 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Thermogenesis |
| REAC:R-HSA-1632852 | 4.7655024582e-05 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Macroautophagy |
| REAC:R-HSA-6804756 | 5.46192807335e-05 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Regulation of TP53 Activity through Phosphorylation |
| REAC:R-HSA-9612973 | 7.95116633082e-05 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Autophagy |
| WP:WP4206 | 0.000182100906477 | 0.666666666667 | PRKAG1 PRKAA1 | Hereditary leiomyomatosis and renal cell carcinoma pathway |
| REAC:R-HSA-9613354 | 0.000187420766709 | 0.666666666667 | PRKAG1 PRKAA2 | Lipophagy |
| REAC:R-HSA-2151209 | 0.000240958766872 | 0.666666666667 | PRKAG1 PRKAA2 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation |
| REAC:R-HSA-5633007 | 0.000284464461562 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Regulation of TP53 Activity |
| CORUM:6888 | 0.000305232445119 | 0.666666666667 | PRKAG1 PRKAA1 | v-ATPase-Ragulator-AXIN/LKB1-AMPK complex |
| REAC:R-HSA-112314 | 0.00039473484794 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-9613829 | 0.000702607572674 | 0.666666666667 | PRKAG1 PRKAA2 | Chaperone Mediated Autophagy |
| REAC:R-HSA-112315 | 0.000864945777315 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Transmission across Chemical Synapses |
| REAC:R-HSA-9615710 | 0.00234745427481 | 0.666666666667 | PRKAG1 PRKAA2 | Microautophagy |
| WP:WP2034 | 0.00258244514586 | 0.666666666667 | PRKAA2 PRKAA1 | Leptin signaling pathway |
| REAC:R-HSA-112316 | 0.0029451340212 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Neuronal System |
| REAC:R-HSA-3700989 | 0.00313081125109 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Transcriptional Regulation by TP53 |
| KEGG:05418 | 0.00345163215546 | 0.666666666667 | PRKAA2 PRKAA1 | Fluid shear stress and atherosclerosis |
| GO:0006110 | 0.00378386515143 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | regulation of glycolytic process |
| KEGG:04140 | 0.00390806659107 | 0.666666666667 | PRKAA2 PRKAA1 | Autophagy - animal |
| GO:1904428 | 0.00405722906526 | 0.666666666667 | PRKAA2 PRKAA1 | negative regulation of tubulin deacetylation |
| KEGG:04150 | 0.00458162707101 | 0.666666666667 | PRKAA2 PRKAA1 | mTOR signaling pathway |
| GO:0043470 | 0.00475834847216 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | regulation of carbohydrate catabolic process |
| REAC:R-HSA-8953897 | 0.00865480168204 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | Cellular responses to external stimuli |
| WP:WP2380 | 0.00875262287344 | 0.666666666667 | PRKAA2 PRKAA1 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| GO:1900542 | 0.00929437307021 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | regulation of purine nucleotide metabolic process |
| GO:0006140 | 0.00996606725847 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | regulation of nucleotide metabolic process |
| WP:WP481 | 0.0112234268693 | 0.666666666667 | PRKAA2 PRKAA1 | Insulin Signaling |
| GO:1903578 | 0.011404996777 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | regulation of ATP metabolic process |
| GO:0006096 | 0.0117851633362 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | glycolytic process |
| GO:0006757 | 0.0121736852044 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | ATP generation from ADP |
| WP:WP3594 | 0.0124193135116 | 0.666666666667 | PRKAA2 PRKAA1 | Circadian rhythm related genes |
| GO:0046031 | 0.0129761581422 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | ADP metabolic process |
| GO:0090043 | 0.0135228859698 | 0.666666666667 | PRKAA2 PRKAA1 | regulation of tubulin deacetylation |
| GO:0009179 | 0.0138131421388 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | purine ribonucleoside diphosphate metabolic process |
| GO:0009135 | 0.0138131421388 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | purine nucleoside diphosphate metabolic process |
| GO:0009185 | 0.0146853637429 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | ribonucleoside diphosphate metabolic process |
| GO:0006165 | 0.0151349156943 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | nucleoside diphosphate phosphorylation |
| REAC:R-HSA-1445148 | 0.015207050821 | 0.666666666667 | PRKAG1 PRKAA2 | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| GO:0046939 | 0.0155935495032 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | nucleotide phosphorylation |
| GO:0009132 | 0.0180261250619 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | nucleoside diphosphate metabolic process |
| KEGG:04151 | 0.0198175756043 | 0.666666666667 | PRKAA2 PRKAA1 | PI3K-Akt signaling pathway |
| GO:0035174 | 0.020283420769 | 0.666666666667 | PRKAA2 PRKAA1 | histone serine kinase activity |
| GO:0004691 | 0.020283420769 | 0.666666666667 | PRKAG1 PRKAA1 | cAMP-dependent protein kinase activity |
| WP:WP3888 | 0.0226746026379 | 0.666666666667 | PRKAA2 PRKAA1 | VEGFA-VEGFR2 Signaling Pathway |
| GO:0043467 | 0.0248678516681 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | regulation of generation of precursor metabolites and energy |
| REAC:R-HSA-1592230 | 0.0255313065434 | 0.666666666667 | PRKAG1 PRKAA2 | Mitochondrial biogenesis |
| GO:0090042 | 0.0283955176165 | 0.666666666667 | PRKAA2 PRKAA1 | tubulin deacetylation |
| GO:0006090 | 0.0288576025313 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | pyruvate metabolic process |
| WP:WP3932 | 0.0309522486098 | 0.666666666667 | PRKAA2 PRKAA1 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| GO:0006109 | 0.0364177948924 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | regulation of carbohydrate metabolic process |
| GO:0004690 | 0.0378589948753 | 0.666666666667 | PRKAG1 PRKAA1 | cyclic nucleotide-dependent protein kinase activity |
| GO:0031588 | 0.0378589948753 | 0.666666666667 | PRKAG1 PRKAA1 | nucleotide-activated protein kinase complex |
| WP:WP4172 | 0.0388642175144 | 0.666666666667 | PRKAA2 PRKAA1 | PI3K-Akt Signaling Pathway |
| WP:WP3595 | 0.0428416541517 | 0.333333333333 | PRKAA1 | mir-124 predicted interactions with cell cycle and differentiation |
| GO:0016241 | 0.0442598881134 | 1.0 | PRKAG1 PRKAA1 PRKAA2 | regulation of macroautophagy |
| GO:0055089 | 0.0486736709081 | 0.666666666667 | PRKAA2 PRKAA1 | fatty acid homeostasis |
| CORUM:771 | 0.0499776345577 | 0.333333333333 | PRKAA1 | NDPKA-AMPKalpha1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PRKAA1 | PRKAG1 | 1.0 | 0.949 | hein_WMM bioplex (PRKAG1) bioplex_WMM youn_WMM hein (PRKAA1) gupta_WMM boldt_WMM |
| PRKAA2 | PRKAG1 | 0.999 | 0.949 | bioplex (PRKAG1) bioplex_WMM youn_WMM gupta_WMM |
| PRKAA1 | PRKAA2 | 0.019 | 0.185 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
Images
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Complex HuMAP2_05529 has an average edge precision of 0.694 which is ranked 1396 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PRKAA2 | HuMAP2_00168 HuMAP2_02825 HuMAP2_03872 HuMAP2_05529 |
| PRKAA1 | HuMAP2_00168 HuMAP2_02825 HuMAP2_03872 HuMAP2_05529 |
| PRKAG1 | HuMAP2_00168 HuMAP2_02825 HuMAP2_03872 HuMAP2_05529 |