hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05533
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| COL5A1 | Collagen alpha-1(V) chain | UniProt NCBI |
| COL8A2 | Collagen alpha-2(VIII) chain (Endothelial collagen) | UniProt NCBI |
| COL2A1 | Collagen alpha-1(II) chain (Alpha-1 type II collagen) [Cleaved into: Collagen alpha-1(II) chain; Chondrocalcin] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8948216 | 4.10886616968e-06 | 1.0 | COL2A1 COL5A1 COL8A2 | Collagen chain trimerization |
| REAC:R-HSA-2022090 | 1.24628263731e-05 | 1.0 | COL2A1 COL5A1 COL8A2 | Assembly of collagen fibrils and other multimeric structures |
| REAC:R-HSA-1442490 | 1.53852062946e-05 | 1.0 | COL2A1 COL5A1 COL8A2 | Collagen degradation |
| REAC:R-HSA-1650814 | 1.70037551742e-05 | 1.0 | COL2A1 COL5A1 COL8A2 | Collagen biosynthesis and modifying enzymes |
| REAC:R-HSA-216083 | 3.03590314156e-05 | 1.0 | COL2A1 COL5A1 COL8A2 | Integrin cell surface interactions |
| REAC:R-HSA-1474290 | 4.28393920683e-05 | 1.0 | COL2A1 COL5A1 COL8A2 | Collagen formation |
| REAC:R-HSA-1474228 | 0.000153481595091 | 1.0 | COL2A1 COL5A1 COL8A2 | Degradation of the extracellular matrix |
| GO:0030020 | 0.000648444632805 | 1.0 | COL2A1 COL5A1 COL8A2 | extracellular matrix structural constituent conferring tensile strength |
| KEGG:04974 | 0.0012386886924 | 0.666666666667 | COL2A1 COL5A1 | Protein digestion and absorption |
| REAC:R-HSA-1474244 | 0.00141029783843 | 1.0 | COL2A1 COL5A1 COL8A2 | Extracellular matrix organization |
| REAC:R-HSA-8874081 | 0.00252791438215 | 0.666666666667 | COL2A1 COL5A1 | MET activates PTK2 signaling |
| REAC:R-HSA-419037 | 0.0033164570092 | 0.666666666667 | COL2A1 COL5A1 | NCAM1 interactions |
| HP:0001083 | 0.00437859029972 | 0.666666666667 | COL2A1 COL5A1 | Ectopia lentis |
| REAC:R-HSA-8875878 | 0.00445214779833 | 0.666666666667 | COL2A1 COL5A1 | MET promotes cell motility |
| REAC:R-HSA-375165 | 0.00818423736949 | 0.666666666667 | COL2A1 COL5A1 | NCAM signaling for neurite out-growth |
| HP:0002758 | 0.00913104209388 | 0.666666666667 | COL2A1 COL5A1 | Osteoarthritis |
| REAC:R-HSA-186797 | 0.00955880978777 | 0.666666666667 | COL2A1 COL5A1 | Signaling by PDGF |
| HP:0100625 | 0.0103735850487 | 0.666666666667 | COL2A1 COL5A1 | Enlarged thorax |
| REAC:R-HSA-3000171 | 0.0106595435179 | 0.666666666667 | COL2A1 COL5A1 | Non-integrin membrane-ECM interactions |
| REAC:R-HSA-3000178 | 0.0143204798819 | 0.666666666667 | COL2A1 COL5A1 | ECM proteoglycans |
| REAC:R-HSA-6806834 | 0.0175395775792 | 0.666666666667 | COL2A1 COL5A1 | Signaling by MET |
| HP:0001634 | 0.0200772827833 | 0.666666666667 | COL2A1 COL5A1 | Mitral valve prolapse |
| HP:0001131 | 0.0225234057432 | 0.666666666667 | COL5A1 COL8A2 | Corneal dystrophy |
| HP:0000541 | 0.0237990042853 | 0.666666666667 | COL2A1 COL5A1 | Retinal detachment |
| HP:0001633 | 0.0271411575623 | 0.666666666667 | COL2A1 COL5A1 | Abnormal mitral valve morphology |
| WP:WP3932 | 0.0309522486098 | 0.666666666667 | COL2A1 COL5A1 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| GO:0005201 | 0.0310032822085 | 1.0 | COL2A1 COL5A1 COL8A2 | extracellular matrix structural constituent |
| HP:0001166 | 0.0314403819239 | 0.666666666667 | COL2A1 COL5A1 | Arachnodactyly |
| HP:0001238 | 0.0409824890748 | 0.666666666667 | COL2A1 COL5A1 | Slender finger |
| HP:0006705 | 0.041834410056 | 0.666666666667 | COL2A1 COL5A1 | Abnormal atrioventricular valve morphology |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| COL5A1 | COL8A2 | 0.413 | 0.571 | bioplex (COL8A2) bioplex_WMM |
| COL8A2 | COL2A1 | 0.077 | 0.352 | bioplex (COL8A2) bioplex_WMM |
| COL5A1 | COL2A1 | 0.012 | 0.146 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05533 has an average edge precision of 0.356 which is ranked 3818 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| COL5A1 | HuMAP2_00859 HuMAP2_04566 HuMAP2_05432 HuMAP2_05533 |
| COL8A2 | HuMAP2_04566 HuMAP2_05161 HuMAP2_05432 HuMAP2_05533 |
| COL2A1 | HuMAP2_04566 HuMAP2_05161 HuMAP2_05432 HuMAP2_05533 |