hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05536
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| VPS29 | Vacuolar protein sorting-associated protein 29 (hVPS29) (PEP11 homolog) (Vesicle protein sorting 29) | UniProt NCBI |
| VPS35 | Vacuolar protein sorting-associated protein 35 (hVPS35) (Maternal-embryonic 3) (Vesicle protein sorting 35) | UniProt NCBI |
| VPS26A | Vacuolar protein sorting-associated protein 26A (Vesicle protein sorting 26A) (hVPS26) | UniProt NCBI |
| TBC1D5 | TBC1 domain family member 5 | UniProt NCBI |
| VPS26B | Vacuolar protein sorting-associated protein 26B (Vesicle protein sorting 26B) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0030904 | 7.01884384365e-11 | 1.0 | VPS26A VPS29 TBC1D5 VPS26B VPS35 | retromer complex |
| GO:0030906 | 1.2197780676e-10 | 0.8 | VPS26A VPS29 VPS26B VPS35 | retromer, cargo-selective complex |
| CORUM:656 | 1.35146690511e-09 | 0.6 | VPS26A VPS29 VPS35 | VPS35-VPS29-VPS26A complex |
| CORUM:1060 | 1.35119464053e-08 | 0.6 | VPS35 VPS26B VPS29 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26B) |
| CORUM:657 | 1.35119464053e-08 | 0.6 | VPS26A VPS29 VPS35 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A) |
| CORUM:1059 | 1.35119464053e-08 | 0.6 | VPS26A VPS29 VPS35 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A) |
| GO:0042147 | 2.09890267681e-07 | 1.0 | VPS26A VPS29 TBC1D5 VPS26B VPS35 | retrograde transport, endosome to Golgi |
| GO:0016482 | 3.80356819159e-06 | 1.0 | VPS26A VPS29 TBC1D5 VPS26B VPS35 | cytosolic transport |
| REAC:R-HSA-3238698 | 4.80586315819e-06 | 0.6 | VPS26A VPS29 VPS35 | WNT ligand biogenesis and trafficking |
| KEGG:04144 | 1.32635921507e-05 | 0.8 | VPS26A VPS29 VPS26B VPS35 | Endocytosis |
| GO:0016197 | 2.07718623633e-05 | 1.0 | VPS26A VPS29 TBC1D5 VPS26B VPS35 | endosomal transport |
| GO:1990126 | 0.00208420080219 | 0.6 | VPS26A VPS29 VPS35 | retrograde transport, endosome to plasma membrane |
| GO:0005768 | 0.00562525789934 | 1.0 | VPS26A VPS29 TBC1D5 VPS26B VPS35 | endosome |
| REAC:R-HSA-195721 | 0.0129604262881 | 0.6 | VPS26A VPS29 VPS35 | Signaling by WNT |
| GO:0016236 | 0.0210321541014 | 0.8 | VPS26A TBC1D5 VPS26B VPS35 | macroautophagy |
| GO:0098796 | 0.0328678033498 | 1.0 | VPS26A VPS29 TBC1D5 VPS26B VPS35 | membrane protein complex |
| GO:0006886 | 0.0442638282809 | 1.0 | VPS26A VPS29 TBC1D5 VPS26B VPS35 | intracellular protein transport |
| GO:0097422 | 0.0450641792523 | 0.4 | VPS26A VPS35 | tubular endosome |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| VPS35 | VPS26A | 1.0 | 0.949 | hein_WMM bioplex (VPS26A) bioplex_WMM Guru hein (VPS26A) gupta_WMM fraction |
| VPS26A | VPS29 | 1.0 | 0.949 | hein_WMM bioplex (VPS26A,VPS29) bioplex_WMM Guru hein (VPS26A) gupta_WMM fraction |
| VPS26A | TBC1D5 | 1.0 | 0.949 | hein_WMM bioplex (VPS26A) bioplex_WMM hein (VPS26A) gupta_WMM |
| VPS26B | TBC1D5 | 1.0 | 0.949 | hein_WMM bioplex (VPS26B) bioplex_WMM hein (VPS26B) |
| VPS26B | VPS29 | 1.0 | 0.949 | hein_WMM bioplex (VPS26B,VPS29) bioplex_WMM Guru hein (VPS26B) fraction boldt_WMM |
| VPS26B | VPS35 | 1.0 | 0.949 | hein_WMM bioplex (VPS26B) bioplex_WMM Guru boldt hein (VPS26B) fraction boldt_WMM |
| VPS35 | VPS29 | 0.999 | 0.949 | hein_WMM bioplex (VPS29) bioplex_WMM Guru gupta_WMM fraction boldt_WMM |
| VPS26B | VPS26A | 0.888 | 0.818 | bioplex (VPS26A,VPS26B) bioplex_WMM fraction |
| TBC1D5 | VPS29 | 0.884 | 0.816 | hein_WMM bioplex (VPS29) bioplex_WMM gupta_WMM |
| VPS35 | TBC1D5 | 0.019 | 0.182 | hein_WMM bioplex_WMM gupta_WMM WMM_only |
Images
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Complex HuMAP2_05536 has an average edge precision of 0.846 which is ranked 785 out of all 6965 complexes.
Related Complexes