hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05545
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TLE5 | TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator) | UniProt NCBI |
| TLE4 | Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4) | UniProt NCBI |
| RIPPLY2 | Protein ripply2 | UniProt NCBI |
| TLE3 | Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3) | UniProt NCBI |
| RIPPLY3 | Protein ripply3 (Down syndrome critical region protein 6) | UniProt NCBI |
| MYBPC2 | Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform) | UniProt NCBI |
| MYLPF | Myosin regulatory light chain 2, skeletal muscle isoform (Fast skeletal myosin light chain 2) (MLC2B) | UniProt NCBI |
| TLE2 | Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2) | UniProt NCBI |
| TLE1 | Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1) | UniProt NCBI |
| RIPPLY1 | Protein ripply1 | UniProt NCBI |
| TBX20 | T-box transcription factor TBX20 (T-box protein 20) | UniProt NCBI |
| MYOM1 | Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-4641265 | 2.47556697885e-11 | 0.416666666667 | TLE1 TLE3 TLE5 TLE4 TLE2 | Repression of WNT target genes |
| REAC:R-HSA-195253 | 8.29741691386e-07 | 0.416666666667 | TLE1 TLE3 TLE5 TLE4 TLE2 | Degradation of beta-catenin by the destruction complex |
| REAC:R-HSA-3769402 | 4.72658909671e-06 | 0.333333333333 | TLE1 TLE3 TLE4 TLE2 | Deactivation of the beta-catenin transactivating complex |
| CORUM:6770 | 3.69160609814e-05 | 0.166666666667 | TLE3 TBX20 | TBX20-TLE3 repressor complex |
| CORUM:6769 | 3.69160609814e-05 | 0.166666666667 | TLE1 TBX20 | TBX20-TLE1 repressor complex |
| CORUM:3124 | 3.69160609814e-05 | 0.166666666667 | TLE2 TLE1 | TLE1-TLE2 complex |
| GO:0070491 | 3.77592614132e-05 | 0.416666666667 | TLE1 TLE3 TLE5 TLE4 TLE2 | repressing transcription factor binding |
| REAC:R-HSA-201722 | 0.000137318569823 | 0.333333333333 | TLE1 TLE3 TLE4 TLE2 | Formation of the beta-catenin:TCF transactivating complex |
| GO:1904837 | 0.000327257119982 | 0.333333333333 | TLE1 TLE3 TLE4 TLE2 | beta-catenin-TCF complex assembly |
| REAC:R-HSA-195721 | 0.000641824306861 | 0.416666666667 | TLE1 TLE3 TLE5 TLE4 TLE2 | Signaling by WNT |
| REAC:R-HSA-2122947 | 0.00116976189597 | 0.25 | TLE2 TLE4 TLE1 | NOTCH1 Intracellular Domain Regulates Transcription |
| GO:0140297 | 0.00195392914054 | 0.5 | TLE5 TLE1 TLE3 TLE4 TLE2 TBX20 | DNA-binding transcription factor binding |
| GO:0090090 | 0.00275467530945 | 0.416666666667 | TLE1 TLE3 TLE5 TLE4 TLE2 | negative regulation of canonical Wnt signaling pathway |
| GO:1990907 | 0.00328477723547 | 0.25 | TLE3 TLE4 TLE1 | beta-catenin-TCF complex |
| REAC:R-HSA-1980143 | 0.00391172386053 | 0.25 | TLE2 TLE4 TLE1 | Signaling by NOTCH1 |
| GO:0030178 | 0.0051663671776 | 0.416666666667 | TLE1 TLE3 TLE5 TLE4 TLE2 | negative regulation of Wnt signaling pathway |
| REAC:R-HSA-201681 | 0.00522969313373 | 0.333333333333 | TLE1 TLE3 TLE4 TLE2 | TCF dependent signaling in response to WNT |
| GO:0003714 | 0.0141327056768 | 0.416666666667 | TLE1 TLE3 TLE5 TLE4 TLE2 | transcription corepressor activity |
| GO:0060828 | 0.022328883124 | 0.416666666667 | TLE1 TLE3 TLE5 TLE4 TLE2 | regulation of canonical Wnt signaling pathway |
| WP:WP383 | 0.02625610321 | 0.166666666667 | MYOM1 MYBPC2 | Striated Muscle Contraction Pathway |
| GO:0009880 | 0.0263574847975 | 0.25 | RIPPLY3 RIPPLY2 RIPPLY1 | embryonic pattern specification |
| GO:0032525 | 0.029754345151 | 0.166666666667 | RIPPLY1 RIPPLY2 | somite rostral/caudal axis specification |
| GO:0060070 | 0.0460490785935 | 0.416666666667 | TLE1 TLE3 TLE5 TLE4 TLE2 | canonical Wnt signaling pathway |
| GO:0005667 | 0.0488444889024 | 0.416666666667 | TLE1 TLE3 TLE5 TLE4 TLE2 | transcription factor complex |
| CORUM:1987 | 0.0499809905632 | 0.0833333333333 | MYOM1 | MYOM1 homodimer complex |
| CORUM:3123 | 0.0499809905632 | 0.0833333333333 | TLE2 | TLE2 homodimer complex |
| CORUM:3125 | 0.0499809905632 | 0.0833333333333 | TLE1 | TLE1 homodimer complex |
| CORUM:3127 | 0.0499809905632 | 0.0833333333333 | TLE1 | TLE-Histone H3 complex |
| CORUM:6768 | 0.0499809905632 | 0.0833333333333 | TBX20 | TBX20-TBX18 repressor complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TLE4 | TLE2 | 1.0 | 0.949 | bioplex (TLE4) bioplex_WMM |
| TLE5 | TLE4 | 0.994 | 0.923 | bioplex (TLE4) bioplex_WMM youn_WMM |
| TLE1 | TLE4 | 0.98 | 0.896 | bioplex (TLE4) bioplex_WMM youn_WMM |
| TLE4 | TLE3 | 0.83 | 0.777 | bioplex (TLE3,TLE4) bioplex_WMM youn_WMM |
| TLE3 | TLE2 | 0.717 | 0.73 | bioplex (TLE3) bioplex_WMM |
| TLE2 | RIPPLY1 | 0.662 | 0.698 | bioplex (RIPPLY1) bioplex_WMM |
| TLE2 | RIPPLY2 | 0.568 | 0.655 | bioplex (RIPPLY2) bioplex_WMM |
| TLE4 | RIPPLY3 | 0.489 | 0.617 | bioplex (TLE4) bioplex_WMM |
| TLE4 | RIPPLY1 | 0.47 | 0.605 | bioplex (RIPPLY1) bioplex_WMM |
| TLE4 | RIPPLY2 | 0.383 | 0.55 | bioplex (RIPPLY2) bioplex_WMM |
| TLE3 | MYBPC2 | 0.3 | 0.497 | bioplex (TLE3) bioplex_WMM |
| TLE4 | TBX20 | 0.215 | 0.464 | bioplex (TBX20) bioplex_WMM |
| TLE3 | TBX20 | 0.201 | 0.45 | bioplex (TBX20) bioplex_WMM |
| TLE1 | TLE3 | 0.141 | 0.406 | bioplex (TLE3) bioplex_WMM youn_WMM |
| TLE5 | RIPPLY2 | 0.099 | 0.359 | bioplex (RIPPLY2) bioplex_WMM |
| TLE3 | RIPPLY2 | 0.098 | 0.357 | bioplex (RIPPLY2) bioplex_WMM |
| TLE3 | MYOM1 | 0.092 | 0.355 | bioplex (TLE3) bioplex_WMM |
| TLE1 | RIPPLY1 | 0.067 | 0.351 | bioplex (RIPPLY1) bioplex_WMM |
| TLE1 | RIPPLY2 | 0.063 | 0.347 | bioplex (RIPPLY2) bioplex_WMM |
| TLE3 | RIPPLY1 | 0.026 | 0.219 | bioplex (RIPPLY1) bioplex_WMM |
| TLE1 | TBX20 | 0.024 | 0.211 | bioplex (TBX20) bioplex_WMM |
| TLE3 | MYLPF | 0.022 | 0.205 | bioplex (TLE3) bioplex_WMM |
| TLE5 | RIPPLY1 | 0.018 | 0.18 | bioplex (RIPPLY1) bioplex_WMM |
| TLE1 | TLE2 | 0.017 | 0.175 | bioplex_WMM WMM_only |
| TLE1 | TLE5 | 0.012 | 0.146 | bioplex_WMM youn_WMM WMM_only |
| TLE5 | TLE2 | 0.011 | 0.14 | bioplex_WMM WMM_only |
| TLE5 | TLE3 | 0.011 | 0.144 | bioplex_WMM youn_WMM WMM_only |
| MYLPF | MYBPC2 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| MYLPF | MYOM1 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| MYBPC2 | MYOM1 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| TLE5 | RIPPLY3 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| TLE1 | MYOM1 | 0.008 | 0.081 | bioplex_WMM WMM_only |
| TLE1 | MYLPF | 0.008 | 0.081 | bioplex_WMM WMM_only |
| TLE1 | MYBPC2 | 0.008 | 0.081 | bioplex_WMM WMM_only |
| TLE1 | RIPPLY3 | 0.008 | 0.081 | bioplex_WMM WMM_only |
| TLE2 | MYLPF | 0.008 | 0.082 | bioplex_WMM WMM_only |
| TLE2 | MYOM1 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| TLE2 | MYBPC2 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| TLE2 | RIPPLY3 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| TLE3 | RIPPLY3 | 0.008 | 0.065 | bioplex_WMM WMM_only |
| TLE4 | MYOM1 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| TLE4 | MYLPF | 0.008 | 0.06 | bioplex_WMM WMM_only |
| TLE4 | MYBPC2 | 0.008 | 0.06 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05545 has an average edge precision of 0.318 which is ranked 4369 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TLE5 | HuMAP2_01916 HuMAP2_05545 HuMAP2_06707 HuMAP2_06880 |
| TLE4 | HuMAP2_01916 HuMAP2_05545 HuMAP2_06707 HuMAP2_06880 |
| RIPPLY2 | HuMAP2_04314 HuMAP2_05545 HuMAP2_06880 |
| TLE3 | HuMAP2_02012 HuMAP2_05532 HuMAP2_05545 |
| RIPPLY3 | HuMAP2_05545 HuMAP2_06880 |
| MYBPC2 | HuMAP2_05545 |
| MYLPF | HuMAP2_05545 |
| TLE2 | HuMAP2_04314 HuMAP2_05545 HuMAP2_06707 HuMAP2_06880 |
| TLE1 | HuMAP2_01916 HuMAP2_05545 HuMAP2_06707 HuMAP2_06880 |
| RIPPLY1 | HuMAP2_04314 HuMAP2_05545 HuMAP2_06880 |
| TBX20 | HuMAP2_05545 |
| MYOM1 | HuMAP2_05545 |