hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05548
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| KLHL42 | Kelch-like protein 42 (Cullin-3-binding protein 9) (Ctb9) (Kelch domain-containing protein 5) | UniProt NCBI |
| NAE1 | NEDD8-activating enzyme E1 regulatory subunit (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Amyloid protein-binding protein 1) (Proto-oncogene protein 1) | UniProt NCBI |
| UBA3 | NEDD8-activating enzyme E1 catalytic subunit (EC 6.2.1.-) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3) | UniProt NCBI |
| UBE2M | NEDD8-conjugating enzyme Ubc12 (EC 2.3.2.-) (NEDD8 carrier protein) (Ubiquitin-conjugating enzyme E2 M) | UniProt NCBI |
| KCTD6 | BTB/POZ domain-containing protein KCTD6 (KCASH3 protein) (Potassium channel tetramerization domain-containing protein 6) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8951664 | 1.05323903619e-07 | 1.0 | KCTD6 UBE2M NAE1 UBA3 KLHL42 | Neddylation |
| CORUM:2162 | 6.70868171695e-06 | 0.4 | UBA3 NAE1 | APPBP1-UBA3 complex |
| REAC:R-HSA-983168 | 0.000106689631566 | 0.8 | KCTD6 UBE2M UBA3 KLHL42 | Antigen processing: Ubiquitination & Proteasome degradation |
| REAC:R-HSA-983169 | 0.000217774869126 | 0.8 | KCTD6 UBE2M UBA3 KLHL42 | Class I MHC mediated antigen processing & presentation |
| GO:0043687 | 0.000259151609636 | 1.0 | KCTD6 UBE2M NAE1 UBA3 KLHL42 | post-translational protein modification |
| GO:0045116 | 0.000616695699567 | 0.6 | NAE1 UBA3 UBE2M | protein neddylation |
| REAC:R-HSA-597592 | 0.000641406598892 | 1.0 | KCTD6 UBE2M NAE1 UBA3 KLHL42 | Post-translational protein modification |
| REAC:R-HSA-1280218 | 0.00256626643698 | 0.8 | KCTD6 UBE2M UBA3 KLHL42 | Adaptive Immune System |
| REAC:R-HSA-392499 | 0.0039377533293 | 1.0 | KCTD6 UBE2M NAE1 UBA3 KLHL42 | Metabolism of proteins |
| GO:0019781 | 0.00450823411379 | 0.4 | UBA3 NAE1 | NEDD8 activating enzyme activity |
| REAC:R-HSA-5676590 | 0.0229182830201 | 0.4 | UBA3 UBE2M | NIK-->noncanonical NF-kB signaling |
| REAC:R-HSA-5607761 | 0.0237053784759 | 0.4 | UBA3 UBE2M | Dectin-1 mediated noncanonical NF-kB signaling |
| KEGG:04120 | 0.0353865382697 | 0.4 | UBA3 UBE2M | Ubiquitin mediated proteolysis |
| REAC:R-HSA-5668541 | 0.0476518941102 | 0.4 | UBA3 UBE2M | TNFR2 non-canonical NF-kB pathway |
| CORUM:7371 | 0.0499494897235 | 0.2 | KCTD6 | CUL3-KCTD6 complex |
| CORUM:7533 | 0.0499494897235 | 0.2 | KLHL42 | Ubiquitin E3 ligase (CUL3, KLHL42) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| UBA3 | NAE1 | 0.966 | 0.875 | bioplex_WMM youn_WMM fraction treiber_WMM |
| NAE1 | UBE2M | 0.37 | 0.544 | bioplex (UBE2M) bioplex_WMM youn_WMM gupta_WMM |
| UBA3 | UBE2M | 0.121 | 0.393 | bioplex (UBE2M) bioplex_WMM |
| KCTD6 | UBE2M | 0.045 | 0.286 | bioplex (UBE2M) bioplex_WMM |
| KLHL42 | UBE2M | 0.024 | 0.214 | bioplex (UBE2M) bioplex_WMM |
| KLHL42 | KCTD6 | 0.008 | 0.028 | bioplex_WMM WMM_only |
| UBA3 | KCTD6 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| NAE1 | KCTD6 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| UBA3 | KLHL42 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| NAE1 | KLHL42 | 0.006 | 0.004 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05548 has an average edge precision of 0.236 which is ranked 5603 out of all 6965 complexes.
Related Complexes