hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05553
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ANKHD1 | Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) | UniProt NCBI |
| ABHD16A | Phosphatidylserine lipase ABHD16A (EC 3.1.-.-) (Alpha/beta hydrolase domain-containing protein 16A) (Abhydrolase domain-containing protein 16A) (HLA-B-associated transcript 5) (hBAT5) (Monoacylglycerol lipase ABHD16A) (EC 3.1.1.23) (Protein G5) | UniProt NCBI |
| STXBP2 | Syntaxin-binding protein 2 (Protein unc-18 homolog 2) (Unc18-2) (Protein unc-18 homolog B) (Unc-18B) | UniProt NCBI |
| SCNN1D | Amiloride-sensitive sodium channel subunit delta (Delta-NaCH) (Epithelial Na(+) channel subunit delta) (Delta-ENaC) (ENaCD) (Nonvoltage-gated sodium channel 1 subunit delta) (SCNED) | UniProt NCBI |
| STX11 | Syntaxin-11 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0012156 | 0.00097535418756 | 0.4 | STXBP2 STX11 | Hemophagocytosis |
| HP:0003281 | 0.00709565752293 | 0.4 | STXBP2 STX11 | Increased serum ferritin |
| HP:0040133 | 0.00792937512816 | 0.4 | STXBP2 STX11 | Abnormal serum ferritin |
| HP:0004311 | 0.0138999712057 | 0.4 | STXBP2 STX11 | Abnormal macrophage morphology |
| CORUM:3196 | 0.0499494897235 | 0.2 | STX11 | FHL4/STX11-ACT complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| STXBP2 | STX11 | 0.659 | 0.696 | bioplex (STX11) bioplex_WMM |
| STX11 | ANKHD1 | 0.052 | 0.301 | bioplex (STX11) bioplex_WMM |
| SCNN1D | STX11 | 0.049 | 0.294 | bioplex (STX11) bioplex_WMM |
| ABHD16A | SCNN1D | 0.041 | 0.27 | bioplex (SCNN1D) bioplex_WMM |
| STXBP2 | SCNN1D | 0.008 | 0.047 | bioplex_WMM WMM_only |
| SCNN1D | ANKHD1 | 0.008 | 0.027 | bioplex_WMM WMM_only |
| STXBP2 | ANKHD1 | 0.007 | 0.011 | bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_05553 has an average edge precision of 0.235 which is ranked 5612 out of all 6965 complexes.
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