hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05564
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TIMP1 | Metalloproteinase inhibitor 1 (Erythroid-potentiating activity) (EPA) (Fibroblast collagenase inhibitor) (Collagenase inhibitor) (Tissue inhibitor of metalloproteinases 1) (TIMP-1) | UniProt NCBI |
| MMP2 | 72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Gelatinase A) (Matrix metalloproteinase-2) (MMP-2) (TBE-1) [Cleaved into: PEX] | UniProt NCBI |
| MMP9 | Matrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) (92 kDa gelatinase) (92 kDa type IV collagenase) (Gelatinase B) (GELB) [Cleaved into: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9] | UniProt NCBI |
| COL12A1 | Collagen alpha-1(XII) chain | UniProt NCBI |
| COL14A1 | Collagen alpha-1(XIV) chain (Undulin) | UniProt NCBI |
| COL4A1 | Collagen alpha-1(IV) chain [Cleaved into: Arresten] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1474228 | 5.87030346239e-11 | 1.0 | COL4A1 COL14A1 MMP2 MMP9 COL12A1 TIMP1 | Degradation of the extracellular matrix |
| REAC:R-HSA-1442490 | 8.77427940368e-10 | 0.833333333333 | MMP9 COL14A1 COL12A1 MMP2 COL4A1 | Collagen degradation |
| REAC:R-HSA-1474244 | 5.14682315036e-09 | 1.0 | COL4A1 COL14A1 MMP2 MMP9 COL12A1 TIMP1 | Extracellular matrix organization |
| REAC:R-HSA-2022090 | 4.38209042643e-07 | 0.666666666667 | MMP9 COL14A1 COL4A1 COL12A1 | Assembly of collagen fibrils and other multimeric structures |
| GO:0030198 | 1.13272677546e-06 | 1.0 | COL4A1 COL14A1 MMP2 MMP9 COL12A1 TIMP1 | extracellular matrix organization |
| REAC:R-HSA-1474290 | 2.29512356464e-06 | 0.666666666667 | MMP9 COL14A1 COL4A1 COL12A1 | Collagen formation |
| GO:0043062 | 2.75531423334e-06 | 1.0 | COL4A1 COL14A1 MMP2 MMP9 COL12A1 TIMP1 | extracellular structure organization |
| WP:WP129 | 4.3749124802e-06 | 0.5 | MMP9 MMP2 TIMP1 | Matrix Metalloproteinases |
| GO:0031012 | 1.02319892914e-05 | 1.0 | COL4A1 COL14A1 MMP2 MMP9 COL12A1 TIMP1 | extracellular matrix |
| WP:WP3624 | 1.47484434565e-05 | 0.5 | MMP9 MMP2 TIMP1 | Lung fibrosis |
| CORUM:2709 | 2.51655344529e-05 | 0.333333333333 | MMP9 TIMP1 | MMP-9-TIMP-1-LRP complex |
| REAC:R-HSA-1592389 | 2.6656058306e-05 | 0.5 | MMP9 MMP2 TIMP1 | Activation of Matrix Metalloproteinases |
| REAC:R-HSA-8948216 | 5.41301437531e-05 | 0.5 | COL14A1 COL4A1 COL12A1 | Collagen chain trimerization |
| KEGG:04974 | 0.000112334489723 | 0.5 | COL14A1 COL4A1 COL12A1 | Protein digestion and absorption |
| REAC:R-HSA-1650814 | 0.000223228442122 | 0.5 | COL14A1 COL4A1 COL12A1 | Collagen biosynthesis and modifying enzymes |
| KEGG:04926 | 0.000464025836468 | 0.5 | MMP9 MMP2 COL4A1 | Relaxin signaling pathway |
| WP:WP4239 | 0.000590025525062 | 0.5 | MMP9 MMP2 COL4A1 | Epithelial to mesenchymal transition in colorectal cancer |
| REAC:R-HSA-6785807 | 0.000645157151235 | 0.5 | MMP9 MMP2 TIMP1 | Interleukin-4 and Interleukin-13 signaling |
| GO:0062023 | 0.000995084496271 | 0.833333333333 | MMP9 COL14A1 COL12A1 MMP2 COL4A1 | collagen-containing extracellular matrix |
| WP:WP2865 | 0.00105843860426 | 0.333333333333 | MMP9 TIMP1 | IL1 and megakaryocytes in obesity |
| WP:WP4561 | 0.00166972224706 | 0.333333333333 | MMP9 MMP2 | Cell migration and invasion through p75NTR |
| WP:WP3617 | 0.00241892882621 | 0.333333333333 | MMP9 MMP2 | Photodynamic therapy-induced NF-kB survival signaling |
| WP:WP4564 | 0.00311734837132 | 0.333333333333 | MMP9 MMP2 | Neural Crest Cell Migration during Development |
| WP:WP2828 | 0.00349951078021 | 0.333333333333 | MMP9 MMP2 | Bladder Cancer |
| WP:WP4565 | 0.00369881973951 | 0.333333333333 | MMP9 MMP2 | Neural Crest Cell Migration in Cancer |
| KEGG:05219 | 0.00414404804148 | 0.333333333333 | MMP9 MMP2 | Bladder cancer |
| MIRNA:hsa-miR-524-5p | 0.00694853153834 | 0.5 | MMP9 MMP2 COL12A1 | hsa-miR-524-5p |
| GO:0005581 | 0.00734442516369 | 0.5 | COL14A1 COL4A1 COL12A1 | collagen trimer |
| WP:WP2324 | 0.0114940114472 | 0.333333333333 | MMP9 MMP2 | AGE/RAGE pathway |
| GO:0035987 | 0.0129043378459 | 0.5 | MMP9 MMP2 COL12A1 | endodermal cell differentiation |
| GO:0030020 | 0.0129043378459 | 0.5 | COL14A1 COL4A1 COL12A1 | extracellular matrix structural constituent conferring tensile strength |
| GO:0044420 | 0.0140408309691 | 0.5 | COL14A1 COL4A1 COL12A1 | extracellular matrix component |
| GO:0001706 | 0.0152420239566 | 0.5 | MMP9 MMP2 COL12A1 | endoderm formation |
| MIRNA:hsa-miR-451a | 0.0159781671505 | 0.333333333333 | MMP9 MMP2 | hsa-miR-451a |
| GO:0030934 | 0.020283420769 | 0.333333333333 | COL14A1 COL12A1 | anchoring collagen complex |
| GO:0007492 | 0.0207293189685 | 0.5 | MMP9 MMP2 COL12A1 | endoderm development |
| WP:WP2431 | 0.021546686463 | 0.333333333333 | MMP9 COL4A1 | Spinal Cord Injury |
| REAC:R-HSA-3928665 | 0.0227674337622 | 0.333333333333 | MMP9 MMP2 | EPH-ephrin mediated repulsion of cells |
| KEGG:04670 | 0.0236020276363 | 0.333333333333 | MMP9 MMP2 | Leukocyte transendothelial migration |
| MIRNA:hsa-miR-29b-3p | 0.0236038745097 | 0.5 | MMP9 MMP2 COL4A1 | hsa-miR-29b-3p |
| KEGG:01522 | 0.0246844798555 | 0.333333333333 | MMP9 MMP2 | Endocrine resistance |
| CORUM:2798 | 0.0249904952816 | 0.166666666667 | MMP2 | MMP-2-CLDN1 complex |
| KEGG:04933 | 0.0252346566494 | 0.333333333333 | MMP2 COL4A1 | AGE-RAGE signaling pathway in diabetic complications |
| KEGG:05200 | 0.0260948095216 | 0.5 | MMP9 MMP2 COL4A1 | Pathways in cancer |
| HP:0006466 | 0.0394527338604 | 0.333333333333 | MMP2 COL12A1 | Ankle flexion contracture |
| MIRNA:hsa-miR-9-5p | 0.0447867989362 | 0.5 | MMP9 MMP2 COL12A1 | hsa-miR-9-5p |
| KEGG:04915 | 0.0452314672739 | 0.333333333333 | MMP9 MMP2 | Estrogen signaling pathway |
| REAC:R-HSA-9009391 | 0.0470157324282 | 0.333333333333 | MMP9 MMP2 | Extra-nuclear estrogen signaling |
| KEGG:05418 | 0.0474671394747 | 0.333333333333 | MMP9 MMP2 | Fluid shear stress and atherosclerosis |
| GO:0005788 | 0.0488951273836 | 0.666666666667 | TIMP1 COL14A1 COL4A1 COL12A1 | endoplasmic reticulum lumen |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MMP9 | TIMP1 | 0.33 | 0.52 | bioplex (MMP9) bioplex_WMM |
| COL12A1 | MMP9 | 0.137 | 0.407 | bioplex (MMP9) bioplex_WMM |
| MMP9 | COL14A1 | 0.093 | 0.355 | bioplex (MMP9) bioplex_WMM |
| MMP2 | COL12A1 | 0.037 | 0.268 | bioplex (MMP2) bioplex_WMM |
| MMP2 | COL14A1 | 0.031 | 0.242 | bioplex (MMP2) bioplex_WMM |
| MMP9 | COL4A1 | 0.023 | 0.211 | bioplex (MMP9) bioplex_WMM |
| MMP2 | COL4A1 | 0.013 | 0.141 | bioplex (MMP2) bioplex_WMM |
| COL12A1 | COL4A1 | 0.01 | 0.104 | bioplex_WMM WMM_only |
| COL14A1 | COL4A1 | 0.01 | 0.104 | bioplex_WMM WMM_only |
| COL12A1 | COL14A1 | 0.008 | 0.084 | bioplex_WMM WMM_only |
| COL12A1 | TIMP1 | 0.008 | 0.046 | bioplex_WMM WMM_only |
| TIMP1 | COL4A1 | 0.008 | 0.013 | bioplex_WMM WMM_only |
| TIMP1 | COL14A1 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| MMP2 | TIMP1 | 0.007 | 0.002 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05564 has an average edge precision of 0.178 which is ranked 6441 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TIMP1 | HuMAP2_01361 HuMAP2_04072 HuMAP2_05564 HuMAP2_06424 |
| MMP2 | HuMAP2_01361 HuMAP2_02826 HuMAP2_05564 HuMAP2_06424 |
| MMP9 | HuMAP2_01361 HuMAP2_04072 HuMAP2_05564 HuMAP2_06424 |
| COL12A1 | HuMAP2_01361 HuMAP2_04072 HuMAP2_05564 HuMAP2_06424 |
| COL14A1 | HuMAP2_01361 HuMAP2_04072 HuMAP2_05564 HuMAP2_06424 |
| COL4A1 | HuMAP2_01361 HuMAP2_02856 HuMAP2_04238 HuMAP2_04483 HuMAP2_05080 HuMAP2_05564 |