hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_05570

Confidence: Medium

Genename	Protein Name	Links
TPX2	Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100)	UniProt NCBI
SSR2	Translocon-associated protein subunit beta (TRAP-beta) (Signal sequence receptor subunit beta) (SSR-beta)	UniProt NCBI
RAB7A	Ras-related protein Rab-7a	UniProt NCBI
RAB5A	Ras-related protein Rab-5A	UniProt NCBI
RAP1B	Ras-related protein Rap-1b (GTP-binding protein smg p21B)	UniProt NCBI
RAB5C	Ras-related protein Rab-5C (L1880) (RAB5L)	UniProt NCBI
RPN1	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1)	UniProt NCBI
RAB5B	Ras-related protein Rab-5B	UniProt NCBI
GNAT3	Guanine nucleotide-binding protein G(t) subunit alpha-3 (Gustducin alpha-3 chain)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-8854214	1.49555874591e-06	0.444444444444	RAB7A RAB5C RAB5A RAB5B	TBC/RABGAPs
KEGG:05146	6.23300432198e-06	0.444444444444	RAB7A RAB5C RAB5A RAB5B	Amoebiasis
REAC:R-HSA-8873719	6.7258150276e-06	0.444444444444	RAB7A RAB5C RAB5A RAB5B	RAB geranylgeranylation
GO:0019003	7.16131178286e-06	0.555555555556	RAB7A RAB5C RAP1B RAB5A RAB5B	GDP binding
WP:WP4301	7.4214414707e-06	0.333333333333	RAB5B RAB5A RAB5C	Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells
REAC:R-HSA-8876198	2.42615347513e-05	0.444444444444	RAB7A RAB5C RAB5A RAB5B	RAB GEFs exchange GTP for GDP on RABs
KEGG:04145	4.01892231868e-05	0.444444444444	RAB7A RAB5C RAB5A RAB5B	Phagosome
KEGG:05152	6.1283131133e-05	0.444444444444	RAB7A RAB5C RAB5A RAB5B	Tuberculosis
KEGG:04962	7.62880882083e-05	0.333333333333	RAB5B RAB5A RAB5C	Vasopressin-regulated water reabsorption
GO:0003924	7.69882643058e-05	0.666666666667	RAB7A GNAT3 RAP1B RAB5A RAB5B RAB5C	GTPase activity
WP:WP4223	8.17509102498e-05	0.444444444444	RAB5B RAB5C RAB5A RAP1B	Ras Signaling
REAC:R-HSA-9007101	8.50813693396e-05	0.444444444444	RAB7A RAB5C RAB5A RAB5B	Rab regulation of trafficking
KEGG:04014	0.000138518257392	0.444444444444	RAB5B RAB5C RAB5A RAP1B	Ras signaling pathway
KEGG:04144	0.00034202987847	0.444444444444	RAB7A RAB5C RAB5A RAB5B	Endocytosis
GO:0032550	0.00164960929622	0.555555555556	RAB7A RAB5C RAP1B RAB5A RAB5B	purine ribonucleoside binding
GO:0032549	0.00164960929622	0.555555555556	RAB7A RAB5C RAP1B RAB5A RAB5B	ribonucleoside binding
GO:0001883	0.00169504870076	0.555555555556	RAB7A RAB5C RAP1B RAB5A RAB5B	purine nucleoside binding
GO:0001882	0.00183738041629	0.555555555556	RAB7A RAB5C RAP1B RAB5A RAB5B	nucleoside binding
GO:0032561	0.00220667392396	0.555555555556	RAB7A RAB5C RAP1B RAB5A RAB5B	guanyl ribonucleotide binding
REAC:R-HSA-392499	0.0022131246723	0.777777777778	RAB7A GNAT3 RPN1 RAB5C SSR2 RAB5B RAB5A	Metabolism of proteins
GO:0019001	0.00226392832593	0.555555555556	RAB7A RAB5C RAP1B RAB5A RAB5B	guanyl nucleotide binding
GO:0032482	0.00293329119138	0.444444444444	RAB7A RAB5C RAB5A RAB5B	Rab protein signal transduction
REAC:R-HSA-8856828	0.0102248921454	0.333333333333	RAB5B RAB5A RAB5C	Clathrin-mediated endocytosis
GO:0017111	0.0123983256109	0.666666666667	RAB7A GNAT3 RAP1B RAB5A RAB5B RAB5C	nucleoside-triphosphatase activity
REAC:R-HSA-6798695	0.0154646635806	0.444444444444	RAB7A RAP1B RAB5C RAB5B	Neutrophil degranulation
GO:0007265	0.017692053213	0.555555555556	RAB7A RAB5C RAP1B RAB5A RAB5B	Ras protein signal transduction
GO:0016462	0.0184480292282	0.666666666667	RAB7A GNAT3 RAP1B RAB5A RAB5B RAB5C	pyrophosphatase activity
GO:0016818	0.0188051035954	0.666666666667	RAB7A GNAT3 RAP1B RAB5A RAB5B RAB5C	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0016817	0.0188051035954	0.666666666667	RAB7A GNAT3 RAP1B RAB5A RAB5B RAB5C	hydrolase activity, acting on acid anhydrides
REAC:R-HSA-199991	0.0491816508588	0.444444444444	RAB7A RAB5C RAB5A RAB5B	Membrane Trafficking
CORUM:2572	0.0499262710315	0.111111111111	RAB5A	RAB5-EEA1 complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
RAB5C	RAB5A	0.858	0.796	hein_WMM bioplex (RAB5A,RAB5C) bioplex_WMM youn_WMM hein (RAB5A) gupta_WMM boldt_WMM treiber_WMM
RAB7A	RAB5C	0.606	0.672	hein_WMM bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
RAB7A	RAB5A	0.27	0.483	bioplex_WMM Guru gupta_WMM fraction boldt_WMM treiber_WMM
RAB7A	RAB5B	0.17	0.426	hein_WMM bioplex_WMM Guru gupta_WMM fraction treiber_WMM
RAP1B	RAB7A	0.11	0.379	hein_WMM bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM
RAB5C	RAB5B	0.032	0.246	hein_WMM bioplex_WMM youn_WMM hein (RAB5B,RAB5C) gupta_WMM treiber_WMM
RPN1	RAB5B	0.032	0.24	Guru youn_WMM gupta_WMM fraction
RPN1	SSR2	0.03	0.237	Guru fraction
GNAT3	RAB5C	0.029	0.23	bioplex (RAB5C) bioplex_WMM boldt boldt_WMM
RAB7A	TPX2	0.022	0.21	hein_WMM bioplex_WMM hein (RAB7A) gupta_WMM
RPN1	RAB5A	0.022	0.206	bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
RAB5A	RAB5B	0.009	0.109	bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
RAP1B	RAB5B	0.009	0.096	bioplex_WMM Guru gupta_WMM fraction
GNAT3	RAB5A	0.008	0.081	bioplex_WMM WMM_only boldt_WMM
RPN1	TPX2	0.007	0.01	youn_WMM gupta_WMM WMM_only
RAB5C	TPX2	0.007	0.006	youn_WMM gupta_WMM WMM_only
RAB7A	RPN1	0.007	0.003	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM
RAB5A	TPX2	0.007	0.001	youn_WMM gupta_WMM WMM_only
RAB5B	TPX2	0.007	0.003	youn_WMM gupta_WMM WMM_only
RAP1B	TPX2	0.007	0.005	bioplex_WMM WMM_only
GNAT3	RPN1	0.007	0.002	boldt boldt_WMM
RAP1B	GNAT3	0.007	0.005	boldt boldt_WMM
RAB7A	GNAT3	0.006	0.005	boldt boldt_WMM
RAP1B	RPN1	0.006	0.003	bioplex_WMM boldt gupta_WMM boldt_WMM
RPN1	RAB5C	0.0	0.013	bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
RAP1B	RAB5C	0.0	0.003	hein_WMM bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM
RAP1B	RAB5A	0.0	0.001	bioplex_WMM Guru gupta_WMM fraction boldt_WMM

Images

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Complex HuMAP2_05570 has an average edge precision of 0.166 which is ranked 6572 out of all 6965 complexes.

Related Complexes

Genename	Complexes
TPX2	HuMAP2_03140 HuMAP2_05570
SSR2	HuMAP2_03081 HuMAP2_03276 HuMAP2_05570 HuMAP2_06798
RAB7A	HuMAP2_00248 HuMAP2_02250 HuMAP2_05110 HuMAP2_05570 HuMAP2_05778 HuMAP2_05948
RAB5A	HuMAP2_01779 HuMAP2_02250 HuMAP2_05110 HuMAP2_05570
RAP1B	HuMAP2_00248 HuMAP2_02250 HuMAP2_04766 HuMAP2_05570 HuMAP2_05778 HuMAP2_05948 HuMAP2_06607
RAB5C	HuMAP2_01779 HuMAP2_02250 HuMAP2_04626 HuMAP2_05110 HuMAP2_05570
RPN1	HuMAP2_01521 HuMAP2_03276 HuMAP2_03979 HuMAP2_05228 HuMAP2_05570 HuMAP2_06982
RAB5B	HuMAP2_02250 HuMAP2_04626 HuMAP2_05570 HuMAP2_05778
GNAT3	HuMAP2_00508 HuMAP2_04626 HuMAP2_04946 HuMAP2_05570

hu.MAP 2.0: Complex View

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Complex: HuMAP2_05570