hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05571
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ACOT13 | Acyl-coenzyme A thioesterase 13 (Acyl-CoA thioesterase 13) (EC 3.1.2.-) (Thioesterase superfamily member 2) [Cleaved into: Acyl-coenzyme A thioesterase 13, N-terminally processed] | UniProt NCBI |
| TALDO1 | Transaldolase (EC 2.2.1.2) | UniProt NCBI |
| HDDC3 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain-containing protein 3) (Metazoan SpoT homolog 1) (MESH1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) ((ppGpp)ase) | UniProt NCBI |
| LAMA1 | Laminin subunit alpha-1 (Laminin A chain) (Laminin-1 subunit alpha) (Laminin-3 subunit alpha) (S-laminin subunit alpha) (S-LAM alpha) | UniProt NCBI |
| LAMA2 | Laminin subunit alpha-2 (Laminin M chain) (Laminin-12 subunit alpha) (Laminin-2 subunit alpha) (Laminin-4 subunit alpha) (Merosin heavy chain) | UniProt NCBI |
| CBFB | Core-binding factor subunit beta (CBF-beta) (Polyomavirus enhancer-binding protein 2 beta subunit) (PEA2-beta) (PEBP2-beta) (SL3-3 enhancer factor 1 subunit beta) (SL3/AKV core-binding factor beta subunit) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP244 | 0.00293450086565 | 0.333333333333 | LAMA1 LAMA2 | Alpha 6 Beta 4 signaling pathway |
| KEGG:05416 | 0.00642969194212 | 0.333333333333 | LAMA1 LAMA2 | Viral myocarditis |
| REAC:R-HSA-8874081 | 0.00834193552282 | 0.333333333333 | LAMA1 LAMA2 | MET activates PTK2 signaling |
| REAC:R-HSA-3000157 | 0.00959640616298 | 0.333333333333 | LAMA1 LAMA2 | Laminin interactions |
| REAC:R-HSA-8875878 | 0.0146740061797 | 0.333333333333 | LAMA1 LAMA2 | MET promotes cell motility |
| KEGG:05412 | 0.015804666162 | 0.333333333333 | LAMA1 LAMA2 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
| KEGG:04512 | 0.0185486461013 | 0.333333333333 | LAMA1 LAMA2 | ECM-receptor interaction |
| KEGG:05410 | 0.0200017533138 | 0.333333333333 | LAMA1 LAMA2 | Hypertrophic cardiomyopathy (HCM) |
| KEGG:05146 | 0.0220231518675 | 0.333333333333 | LAMA1 LAMA2 | Amoebiasis |
| KEGG:05414 | 0.0220231518675 | 0.333333333333 | LAMA1 LAMA2 | Dilated cardiomyopathy (DCM) |
| WP:WP4658 | 0.02454095485 | 0.333333333333 | LAMA1 LAMA2 | Small cell lung cancer |
| KEGG:05222 | 0.0257907962007 | 0.333333333333 | LAMA1 LAMA2 | Small cell lung cancer |
| KEGG:05145 | 0.0269209504846 | 0.333333333333 | LAMA1 LAMA2 | Toxoplasmosis |
| REAC:R-HSA-3000171 | 0.0350388564803 | 0.333333333333 | LAMA1 LAMA2 | Non-integrin membrane-ECM interactions |
| REAC:R-HSA-3000178 | 0.0470157324282 | 0.333333333333 | LAMA1 LAMA2 | ECM proteoglycans |
| CORUM:5770 | 0.0499726005494 | 0.166666666667 | CBFB | RUNX1-CBF-beta-DNA complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HDDC3 | TALDO1 | 0.053 | 0.301 | fraction |
| HDDC3 | ACOT13 | 0.041 | 0.271 | fraction |
| TALDO1 | CBFB | 0.026 | 0.224 | bioplex_WMM fraction |
| TALDO1 | LAMA2 | 0.023 | 0.207 | fraction |
| TALDO1 | LAMA1 | 0.023 | 0.207 | fraction |
| ACOT13 | TALDO1 | 0.006 | 0.008 | bioplex_WMM WMM_only |
| ACOT13 | LAMA2 | 0.005 | 0.009 | fraction |
Images
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Complex HuMAP2_05571 has an average edge precision of 0.175 which is ranked 6473 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ACOT13 | HuMAP2_00269 HuMAP2_01151 HuMAP2_01744 HuMAP2_01973 HuMAP2_03180 HuMAP2_03550 HuMAP2_05571 HuMAP2_06557 HuMAP2_06565 |
| TALDO1 | HuMAP2_00823 HuMAP2_02686 HuMAP2_05233 HuMAP2_05571 |
| HDDC3 | HuMAP2_00269 HuMAP2_00327 HuMAP2_01744 HuMAP2_01973 HuMAP2_02637 HuMAP2_03180 HuMAP2_05233 HuMAP2_05571 HuMAP2_06557 |
| LAMA1 | HuMAP2_05571 |
| LAMA2 | HuMAP2_05571 |
| CBFB | HuMAP2_01436 HuMAP2_05571 |